共查询到20条相似文献,搜索用时 46 毫秒
1.
2.
Pax-6, a murine paired box gene, is expressed in the developing CNS. 总被引:65,自引:0,他引:65
A multigene family of paired-box-containing genes (Pax genes) has been identified in the mouse. In this report, we describe the expression pattern of Pax-6 during embryogenesis and the isolation of cDNA clones spanning the entire coding region. The Pax-6 protein consists of 422 amino acids as deduced from the longest open reading frame and contains, in addition to the paired domain, a paired-type homeodomain. Beginning with day 8 of gestation, Pax-6 is expressed in discrete regions of the forebrain and the hindbrain. In the neural tube, expression is mainly confined to mitotic active cells in the ventral ventricular zone along the entire anteroposterior axis starting at day 8.5 of development. Pax-6 is also expressed in the developing eye, the pituitary and the nasal epithelium. 相似文献
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
Plaza S De Jong DM Gehring WJ Miller DJ 《Journal of experimental zoology. Part B. Molecular and developmental evolution》2003,299(1):26-35
Cnidarians are the simplest animals in which distinct eyes are present. We have previously suggested that cnidarian Pax-Cam might represent a precursor of the Pax-6 class. Here we show that when expressed in Drosophila imaginal discs, Pax-Cam chimeric proteins containing the C-terminal region of EY were capable of eye induction and driving expression of a reporter gene under the control of a known EY target (the sine oculis gene). Whilst these results are consistent with a Pax-6-like function for Pax-Cam, in band shift experiments we were unable to distinguish the DNA-binding behaviour of the Pax-Cam Paired domain from that of a second Acropora Pax protein, Pax-Bam. The ability of a Pax-Bam/EY chimera to also induce eye formation in leg imaginal discs, together with the in vitro data, cast doubt on previously assumed direct relationships between cnidarian Pax genes and the Pax-6 and Pax-2/5/8 classes of bilateral animals. 相似文献
16.
17.
18.
19.
Chun JT Di Dato V D'Andrea B Zannini M Di Lauro R 《Molecular endocrinology (Baltimore, Md.)》2004,18(11):2817-2829