共查询到20条相似文献,搜索用时 15 毫秒
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Molecular Biology - The process of inflammation is the body’s natural defense response to the penetration of foreign substances and molecules from the outside. Many proteins, signaling... 相似文献
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染色质重塑是真核生物表观遗传调控的重要方式.通过对染色质物理结构的调节,染色质重塑在高等动植物干细胞的自我更新及分化、器官和个体发育以及肿瘤发生等多种生物学过程中发挥重要作用.近年来,高等动植物染色质重塑方面的研究已经成为表观遗传学研究领域的热点.本综述总结近年来有关高等动植物染色质重塑的重要研究报道,介绍了染色质重塑的结构机制、分析比较了高等动植物染色质重塑复合体的组成及其生物学功能的多样性,并着重综述了高等植物SWI/SNF染色质重塑复合体各组分在调控植物发育与逆境生长等方面的功能,以期为今后植物中染色质重塑的研究提供启示. 相似文献
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Liesbeth Vercruyssen Aurine Verkest Nathalie Gonzalez Ken S. Heyndrickx Dominique Eeckhout Soon-Ki Han Teddy Jégu Rafal Archacki Jelle Van Leene Megan Andriankaja Stefanie De Bodt Thomas Abeel Frederik Coppens Stijn Dhondt Liesbeth De Milde Mattias Vermeersch Katrien Maleux Kris Gevaert Andrzej Jerzmanowski Moussa Benhamed Doris Wagner Klaas Vandepoele Geert De Jaeger Dirk Inzé 《The Plant cell》2014,26(1):210-229
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Rafal Archacki Daniel Buszewicz Tomasz J. Sarnowski Elzbieta Sarnowska Anna T. Rolicka Takayuki Tohge Alisdair R. Fernie Yusuke Jikumaru Maciej Kotlinski Roksana Iwanicka-Nowicka Katarzyna Kalisiak Jacek Patryn Joanna Halibart-Puzio Yuji Kamiya Seth J. Davis Marta K. Koblowska Andrzej Jerzmanowski 《PloS one》2013,8(3)
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Although ubiquitously present in chromatin, the function of the linker histone subtypes is partly unknown and contradictory studies on their properties have been published. To explore whether the various H1 subtypes have a differential role in the organization and dynamics of chromatin we have incorporated all of the somatic human H1 subtypes into minichromosomes and compared their influence on nucleosome spacing, chromatin compaction and ATP-dependent remodeling. H1 subtypes exhibit different affinities for chromatin and different abilities to promote chromatin condensation, as studied with the Atomic Force Microscope. According to this criterion, H1 subtypes can be classified as weak condensers (H1.1 and H1.2), intermediate condensers (H1.3) and strong condensers (H1.0, H1.4, H1.5 and H1x). The variable C-terminal domain is required for nucleosome spacing by H1.4 and is likely responsible for the chromatin condensation properties of the various subtypes, as shown using chimeras between H1.4 and H1.2. In contrast to previous reports with isolated nucleosomes or linear nucleosomal arrays, linker histones at a ratio of one per nucleosome do not preclude remodeling of minichromosomes by yeast SWI/SNF or Drosophila NURF. We hypothesize that the linker histone subtypes are differential organizers of chromatin, rather than general repressors. 相似文献
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Sebastian P. Sacharowski Dominika M. Gratkowska Elzbieta A. Sarnowska Paulina Kondrak Iga Jancewicz Aimone Porri Ernest Bucior Anna T. Rolicka Rainer Franzen Justyna Kowalczyk Katarzyna Pawlikowska Bruno Huettel Stefano Torti Elmon Schmelzer George Coupland Andrzej Jerzmanowski Csaba Koncz Tomasz J. Sarnowski 《The Plant cell》2015,27(7):1889-1906
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Components of the Human SWI/SNF Complex Are Enriched in Active Chromatin and Are Associated with the Nuclear Matrix 总被引:26,自引:0,他引:26 下载免费PDF全文
Biochemical and genetic evidence suggest that the SWI/SNF complex is involved in the remodeling of chromatin during gene activation. We have used antibodies specific against three human subunits of this complex to study its subnuclear localization, as well as its potential association with active chromatin and the nuclear skeleton. Immunofluorescence studies revealed a punctate nuclear labeling pattern that was excluded from the nucleoli and from regions of condensed chromatin. Dual labeling failed to reveal significant colocalization of BRG1 or hBRM proteins with RNA polymerase II or with nuclear speckles involved in splicing. Chromatin fractionation experiments showed that both soluble and insoluble active chromatin are enriched in the hSWI/SNF proteins as compared with bulk chromatin. hSWI/SNF proteins were also found to be associated with the nuclear matrix or nuclear scaffold, suggesting that a fraction of the hSWI/SNF complex could be involved in the chromatin organization properties associated with matrix attachment regions. 相似文献
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