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Binding of nuclear proteins to promoter elements of the mouse alpha A-crystallin gene 总被引:10,自引:0,他引:10
B Sommer A B Chepelinsky J Piatigorsky 《The Journal of biological chemistry》1988,263(30):15666-15672
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Novel regulation of transcription initiation of the peptide IX gene of adenovirus 2. 总被引:4,自引:1,他引:3
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T Matsui 《Molecular and cellular biology》1989,9(10):4265-4271
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Binding sites of HeLa cell nuclear proteins on the upstream region of adenovirus type 5 E1A gene. 总被引:6,自引:3,他引:3
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Twenty one binding sites of HeLa cell nuclear proteins were identified on the upstream region of adenovirus type 5 E1A gene using DNase I footprint assay. The proximal promoter region contained five binding sites that overlapped the cap site, TATA box, TATA-like sequence, CCAAT box, and -100 region relative to the E1A cap site(+1). The -190 region was a potential site for octamer-motif binding proteins, such as NFIII and OBP100. An upstream copy of the E1A enhancer element 1 was the site for a factor (E1A-F) with the binding specificity of XGGAYGT (X = A, C; Y = A, T). E1A-F factor also bound to three other sites, one of which coincided with the distal E1A enhancer element. The distal element also contained a potential site for ATF factor. The adenovirus minimal origin of DNA replication competed for DNA-protein complex formation on the CCAAT and TATA box region and the -190 region, suggesting that these regions interacted with a common or related factor. 相似文献
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