共查询到20条相似文献,搜索用时 35 毫秒
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Norman Morrison Dan Bearden Jacob G. Bundy Tim Collette Felicity Currie Matthew P. Davey Nathan S. Haigh David Hancock Oliver A. H. Jones Simone Rochfort Susanna-Assunta Sansone Dalibor Štys Quincy Teng Dawn Field Mark R. Viant 《Metabolomics : Official journal of the Metabolomic Society》2007,3(3):203-210
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A key point in the analysis of dynamical models of biological systems is to handle systems of relatively high dimensions.
In the present paper we propose a method to hierarchically organize a certain type of piecewise affine (PWA) differential
systems. This specific class of systems has been extensively studied for the past few years, as it provides a good framework
to model gene regulatory networks. The method, shown on several examples, allows a qualitative analysis of the asymptotic
behavior of a PWA system, decomposing it into several smaller subsystems. This technique, based on the well-known strongly
connected components decomposition, is not new. However, its adaptation to the non-smooth PWA differential equations turns
out to be quite relevant because of the strong discrete structure underlying these equations. Its biological relevance is
shown on a 7-dimensional PWA system modeling the gene network responsible for the carbon starvation response in Escherichia coli.
相似文献
Laurent Tournier (Corresponding author)Email: |
Jean-Luc GouzéEmail: |
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Sub-Antarctic Marion Island has had a permanent research station for 50 years and the islands Wandering Albatrosses have been intensively studied for 20 years. The reactions of breeding birds to approaches by a human on foot were recorded. Three response variables were calculated: intensity of vocal reaction (IVR), intensity of non-vocal reaction (INR) and overall response index (ORI). At 5 m from the nest, twice as many birds stood and/or vocalised as at 15 m. Nearest neighbour distance, age and gender did not explain individual variability of responses. Study colony birds had higher IVR scores than non-study colony birds; birds at colonies closest to the station had the highest ORI scores. A better breeding record was associated with lower IVR and ORI scores, but a causative relationship remains to be demonstrated. A minimum viewing distance of 25 m is recommended for breeding Wandering Albatrosses.
相似文献
Marienne S. de VilliersEmail: Fax: +27-21-6503434 |
John CooperEmail: |
Peter G. RyanEmail: |
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The recent sequencing of the first tree genome, that of the black cottonwood (Populus trichocarpa), opens a new chapter in tree functional genomics. While the completion of the genome is a milestone, mobilizing this significant
resource for better understanding the growth and development of woody perennials will be an even greater undertaking in the
years to come. In other model organisms, a critical tool for high-throughput analysis of gene function has been the generation
of large mutagenized populations. Some mutagenesis technologies and approaches cannot be applied to trees because of their
typically outcrossing breeding systems, high heterozygosity, large body size, and delayed flowering. In contrast, gene-tagging
approaches that use insertional mutagenesis to create dominant phenotypes are ideally suited for trees and, especially, Populus. Both activation tagging and enhancer trap programs have been successful in identifying new genes important to tree development.
The generation of genome-wide insertional mutant populations, which provide direct functional links between genes and phenotypes,
should help to integrate in silico analyses of gene and protein expression, association studies of natural genetic polymorphism, and phenotypic analyses of
adaptation and development.
相似文献
Victor BusovEmail: |
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Stavros Ioannidis 《Biology & philosophy》2008,23(4):567-578
Evolutionary developmental biology (Evo-Devo) is a new and rapidly developing field of biology which focuses on questions
in the intersection of evolution and development and has been seen by many as a potential synthesis of these two fields. This
synthesis is the topic of the books reviewed here. Integrating Evolution and Development (edited by Roger Sansom and Robert
Brandon), is a collection of papers on conceptual issues in Evo-Devo, while From Embryology to Evo-Devo (edited by Manfred
Laubichler and Jane Maienschein) is a history of the problem of the relations between ontogeny and phylogeny.
相似文献
Stavros IoannidisEmail: |
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The recent contribution by Jarmila Kukalová-Peck on Hennigian phylogenetics and hexapod limb evolution is critically evaluated.
相似文献
Michael S. Engel (Corresponding author)Email: |
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Margaret Otlowski 《Journal of bioethical inquiry》2007,4(2):135-150
This paper provides a legal overview of key issues associated with donation of genetic samples and information from a donor
perspective. In particular, it addresses the property status of samples as well as issues in respect of consent, privacy,
commercialisation and benefit sharing. The paper highlights the need for appropriate protection and safeguards for individuals,
but also, importantly, for understanding what donors actually think and want in terms of genetic research and the use of their
samples and information. The paper seeks to emphasise the importance of transparency and accountability in the conduct of
research in order to maximise donor participation and confidence and public trust in general.
相似文献
Margaret OtlowskiEmail: |
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Peter Godfrey-Smith 《Biology & philosophy》2007,22(3):429-437
Jablonka and Lamb's claim that evolutionary biology is undergoing a ‘revolution’ is queried. But the very concept of revolutionary
change has uncertain application to a field organized in the manner of contemporary biology. The explanatory primacy of sequence
properties is also discussed.
相似文献
Peter Godfrey-SmithEmail: |
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Terry Harmer 《Cluster computing》2007,10(3):277-285
Gridcast is an R&D project investigating grid ideas and technologies in the broadcasting technical infrastructure. In this
paper I discuss the business and technical issues in building infrastructures to support broadcasters and outline the structure
of the Gridcast grid-based service oriented architecture for broadcasting playout support.
相似文献
Terry HarmerEmail: |
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Event-related brain potentials (ERP) are important neural correlates of cognitive processes. In the domain of language processing,
the N400 and P600 reflect lexical-semantic integration and syntactic processing problems, respectively. We suggest an interpretation
of these markers in terms of dynamical system theory and present two nonlinear dynamical models for syntactic computations
where different processing strategies correspond to functionally different regions in the system’s phase space.
相似文献
Peter beim GrabenEmail: |
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Machado RR Lima Filho ES Jardim DF Ferreira MA de Faria CG Duarte RS Lesche B 《European biophysics journal : EBJ》2008,38(1):111-119
An interferometer that measures the refractive index changes due to bacterial metabolism is described. The apparatus permits
simultaneous and real time measurement of bacterial growth in several samples of slowly growing mycobacteria. The error sources
are discussed and the sensitivity of the apparatus is tested. For the species Mycobacterium bovis BCG and M. smegmatis, a relation between refractive index change and bacterial concentration is determined experimentally and the time constant
of bacterial growth is measured.
相似文献
B. LescheEmail: |
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Debates over adaptationism can be clarified and partially resolved by careful consideration of the ‘grain’ at which evolutionary
processes are described. The framework of ‘adaptive landscapes’ can be used to illustrate and facilitate this investigation.
We argue that natural selection may have special status at an intermediate grain of analysis of evolutionary processes. The
cases of sickle-cell disease and genomic imprinting are used as case studies.
相似文献
Peter Godfrey-SmithEmail: |
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Anonymous communications in the Internet 总被引:1,自引:0,他引:1
Arjan Durresi 《Cluster computing》2007,10(1):57-66
With the growth and acceptance of the Internet, there has been increased interest in maintaining anonymity in the network.
By using traffic analysis, it is possible to infer who is talking to whom over the Internet. We present a novel approach to
hide the senders and the receivers of messages. Routes are chosen and frames traverse these routes. Each frame consists of
a token and a node can send a message through a frame only when the corresponding token is free. The advantage of our protocol
is that it poses limited bandwidth overhead when there is at least some traffic, while posing minimal bandwidth overhead when
there is no traffic at all.
相似文献
Arjan DurresiEmail: |
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Roger Sansom 《Biology & philosophy》2008,23(4):475-491
I show that gene regulation networks are qualitatively consistent and therefore sufficiently similar to linearly seperable
connectionist networks to warrant that the connectionist framework be applied to gene regulation. On this view, natural selection
designs gene regulation networks to overcome the difficulty of development. I offer some general lessons about their evolvability
that can be learned by examining the generic features of connectionist networks.
相似文献
Roger SansomEmail: |