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Michael Thomm 《FEMS microbiology reviews》1996,18(2-3):159-171
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Population genetic theory of gene duplication suggests that the preservation of duplicate copies requires functional divergence
upon duplication. Genes that can be readily modified to produce new gene expression patterns may thus be duplicated often.
In yeast, genes exhibit dichotomous expression patterns based on their promoter architectures. The expression of genes that
contain TATA box or occupied proximal nucleosome (OPN) tends to be variable and respond to external signals. On the other
hand, genes without TATA box or with depleted proximal nucleosome (DPN) are expressed constitutively. We find that recent
duplicates in the yeast genome are heavily biased to be TATA box containing genes and not to be DPN genes. This suggests that
variably expressed genes, due to the functional organization in their promoters, have higher duplicability than constitutively
expressed genes. 相似文献
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Properties of promoters cloned randomly from the Saccharomyces cerevisiae genome. 总被引:4,自引:3,他引:1 下载免费PDF全文
G M Santangelo J Tornow C S McLaughlin K Moldave 《Molecular and cellular biology》1988,8(10):4217-4224
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