共查询到20条相似文献,搜索用时 31 毫秒
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Salat D Liefke R Wiedenmann J Borggrefe T Oswald F 《Molecular and cellular biology》2008,28(10):3502-3512
Notch is a transmembrane receptor that determines cell fates and pattern formation in all animal species. After specific ligand binding, the intracellular part of Notch is cleaved off and translocates to the nucleus, where it targets the DNA binding protein RBP-Jkappa. In the absence of Notch, RBP-Jkappa represses Notch target genes by recruiting a corepressor complex. We and others have previously identified SHARP as one component of this complex. Here, we show that the corepressor ETO as well as the leukemogenic fusion protein AML1/ETO directly interacts with SHARP, that ETO is part of the endogenous RBP-Jkappa-containing corepressor complex, and that ETO is found at Notch target gene promoters. In functional assays, corepressor ETO, but not AML1/ETO, augments SHARP-mediated repression in an histone deacetylase-dependent manner. Furthermore, either the knockdown of ETO or the overexpression of AML1/ETO activates Notch target genes. Therefore, we propose that AML1/ETO can disturb the normal, repressive function of ETO at Notch target genes. This activating (or derepressing) effect of AML1/ETO may contribute to its oncogenic potential in myeloid leukemia. 相似文献
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HES and HERP families: multiple effectors of the Notch signaling pathway 总被引:38,自引:0,他引:38
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Franz Oswald Patrick Rodriguez Benedetto Daniele Giaimo Zeus A. Antonello Laura Mira Gerhard Mittler Verena N. Thiel Kelly J. Collins Nassif Tabaja Wiebke Cizelsky Melanie Rothe Susanne J. Kühl Michael Kühl Francesca Ferrante Kerstin Hein Rhett A. Kovall Maria Dominguez Tilman Borggrefe 《Nucleic acids research》2016,44(10):4703-4720
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Calderon MR Verway M An BS DiFeo A Bismar TA Ann DK Martignetti JA Shalom-Barak T White JH 《The Journal of biological chemistry》2012,287(12):8662-8674
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Iso T Sartorelli V Poizat C Iezzi S Wu HY Chung G Kedes L Hamamori Y 《Molecular and cellular biology》2001,21(17):6080-6089