共查询到20条相似文献,搜索用时 15 毫秒
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Transcriptional regulatory networks underlying gene expression changes in Huntington's disease
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Jeffrey P Cantle Robert M Bragg Peter J Skene Sydney R Coffey Dani E Bergey Vanessa C Wheeler Marcy E MacDonald Nitin S Baliga Jim Rosinski Leroy E Hood Jeffrey B Carroll Nathan D Price 《Molecular systems biology》2018,14(3)
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BEL1‐LIKE HOMEODOMAIN 11 regulates chloroplast development and chlorophyll synthesis in tomato fruit
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![点击此处可从《The Plant journal : for cell and molecular biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Lanhuan Meng Zhongqi Fan Qiang Zhang Cuicui Wang Ying Gao Yikang Deng Benzhong Zhu Hongliang Zhu Jianye Chen Wei Shan Xueren Yin Silin Zhong Donald Grierson Cai‐Zhong Jiang Yunbo Luo Da‐Qi Fu 《The Plant journal : for cell and molecular biology》2018,94(6):1126-1140
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Gong‐Hong Wei Gwenael Badis Michael F Berger Teemu Kivioja Kimmo Palin Martin Enge Martin Bonke Arttu Jolma Markku Varjosalo Andrew R Gehrke Jian Yan Shaheynoor Talukder Mikko Turunen Mikko Taipale Hendrik G Stunnenberg Esko Ukkonen Timothy R Hughes Martha L Bulyk Jussi Taipale 《The EMBO journal》2010,29(13):2147-2160
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Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells
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Tapan Kumar Mistri Arun George Devasia Lee Thean Chu Wei Ping Ng Florian Halbritter Douglas Colby Ben Martynoga Simon R Tomlinson Ian Chambers Paul Robson Thorsten Wohland 《EMBO reports》2015,16(9):1177-1191
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Chromatin state analysis of the barley epigenome reveals a higher‐order structure defined by H3K27me1 and H3K27me3 abundance
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Katie Baker Taniya Dhillon Isabelle Colas Nicola Cook Iain Milne Linda Milne Micha Bayer Andrew J. Flavell 《The Plant journal : for cell and molecular biology》2015,84(1):111-124
Combinations of histones carrying different covalent modifications are a major component of epigenetic variation. We have mapped nine modified histones in the barley seedling epigenome by chromatin immunoprecipitation next‐generation sequencing (ChIP‐seq). The chromosomal distributions of the modifications group them into four different classes, and members of a given class also tend to coincide at the local DNA level, suggesting that global distribution patterns reflect local epigenetic environments. We used this peak sharing to define 10 chromatin states representing local epigenetic environments in the barley genome. Five states map mainly to genes and five to intergenic regions. Two genic states involving H3K36me3 are preferentially associated with constitutive gene expression, while an H3K27me3‐containing genic state is associated with differentially expressed genes. The 10 states display striking distribution patterns that divide barley chromosomes into three distinct global environments. First, telomere‐proximal regions contain high densities of H3K27me3 covering both genes and intergenic DNA, together with very low levels of the repressive H3K27me1 modification. Flanking these are gene‐rich interior regions that are rich in active chromatin states and have greatly decreased levels of H3K27me3 and increasing amounts of H3K27me1 and H3K9me2. Lastly, H3K27me3‐depleted pericentromeric regions contain gene islands with active chromatin states separated by extensive retrotransposon‐rich regions that are associated with abundant H3K27me1 and H3K9me2 modifications. We propose an epigenomic framework for barley whereby intergenic H3K27me3 specifies facultative heterochromatin in the telomere‐proximal regions and H3K27me1 is diagnostic for constitutive heterochromatin elsewhere in the barley genome. 相似文献
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