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1.
Eman M. Alissa Suhad M. Bahjri Waqar H. Ahmed Nabeel Al-Ama Gordon A. A. Ferns 《Biological trace element research》2009,131(3):215-228
Chromium deficiency is associated with impaired glucose tolerance (IGT) and dyslipidemia. Hence, the objective of the current
study was to investigate chromium status among Saudi men with and without established cardiovascular disease (CVD) and its
relationship to glucose tolerance, lipid profile and other established CVD risk factors. We measured serum and urine chromium
concentrations, fasted lipid profile, plasma glucose, and serum lipid peroxide in 130 Saudi men with an established history
of myocardial infarction and 130 age-matched controls without established CVD. Patients with established CVD had higher serum
triglycerides (p < 0.05) and plasma glucose (p < 0.0001) and lower serum and urinary chromium concentrations (p < 0.0001) than controls. Serum chromium was inversely correlated with plasma glucose among cases and controls (r = −0.189, p < 0.05 and r = −0.354, p < 0.00001, respectively). Plasma glucose (OR 1.127, CI 1.0–1.269, p < 0.05), serum chromium (OR 0.99, CI 0.985–0.995, p < 0.0001), and urinary chromium (OR 0.988, CI 0.981–0.995, p < 0.001) were independently associated with the presence of established coronary disease applying this model. While chromium
metabolism appears to be altered in individuals with CVD, it is unclear whether chromium supplementation would be effective
in CVD prevention among patients with IGT. This would need to be tested in long-term outcome trials. 相似文献
2.
Lucianna Fernandes J. C. Marques Carmen Marino Donangelo Juliana Gastao Franco Luciane Pires Aderval Severino Luna Gustavo Casimiro-Lopes Patricia Cristina Lisboa Josely Correa Koury 《Biological trace element research》2011,142(3):415-423
Intense physical activity is associated with biological adaptations involving hormones and trace elements. Zinc supplementation
may affect plasma copper concentration, thyroid-stimulating hormone (TSH), thyroid hormones, insulin, and glucose homeostasis,
but data in athletes are scarce. The aim of this study was to evaluate in competitive athletes (cyclists, n = 7, 32 ± 8 years) the effect of zinc supplementation (22 mg/day as zinc gluconate) during 30 days, and discontinuation using
placebo (maltodextrin) during the following 30 days, on plasma zinc and copper concentrations, serum thyroid hormones, insulin
and glucose levels, and HOMA2-IR. Compared to baseline, plasma zinc and Zn:Cu plasma ratio increased, but plasma copper decreased
after zinc supplementation (day 30) and discontinuation (day 60) (p < 0.05). Zn supplementation and discontinuation had no effect on TSH, T3, and T4. Fasting serum insulin and HOMA2-IR increased
(27% and 47%, respectively) on day 60 compared to baseline (p = 0.03), suggesting a delayed effect of zinc supplementation. Moreover, plasma zinc was positively associated with serum
insulin (r = 0.87, p = 0.009) and HOMA2-IR (r = 0.81, p = 0.03) after zinc supplementation (day 30), indicating that supplemental zinc may impair glucose utilization in cyclists. 相似文献
3.
Asghar Ghasemi Saleh Zahediasl Leila Syedmoradi Fereidoun Azizi 《Biological trace element research》2010,136(1):18-25
This study aims at determining possible association between serum magnesium (Mg) concentrations and metabolic syndrome (MetS)
in elderly subjects. Subjects were 137 men and women aged 60 to 90 years, selected from among participants of the Tehran Lipid
and Glucose Study after excluding those taking medications for hypertension and dyslipidemia. Serum Mg levels were measured
by atomic absorption spectrometry and MetS was defined according to ATP III criteria. The overall prevalence of MetS was 43.8%.
Among MetS components, only plasma glucose showed a negative correlation with serum Mg concentrations (r = −0.194, p = 0.024). Subjects with MetS had significantly lower serum Mg concentrations compared with non-MetS ones (2.09 ± 0.03 vs.
2.18 ± 0.03 mg/dL, p = 0.033) even after adjustments with MetS components except for hyperglycemia (2.04 ± 0.06 vs. 2.20 ± 0.05 mg/dL, p = 0.011). However, after adjustment for hyperglycemia per se or along with the other MetS components, the significant difference
between serum Mg levels in subjects with and without MetS disappeared. In conclusion, serum Mg level is diminished in elderly
subjects with MetS, and hyperglycemia may play dominant role in this decrease; however, the results do not clarify whether
the low serum Mg level is a consequence of hyperglycemia or is a risk factor contributing to its development. 相似文献
4.
The objective was to determine the prevalence of iodine deficiency among hypothyroid patients and the effect of dietary goitrogens
on indices of iodine and thyroid status. This is a case-control study of 106 subjects who were recruited from King Abdulaziz
University Hospital, Jeddah. Blood and urine were collected for serum thyroid hormones, thyroid autoantibodies, thyroglobulin
(Tg) and urinary iodine concentration (UIC). Dietary iodine and goitrogenic food intake were assessed by questionnaire. Using
World Health Organization (WHO) cutoff values for UIC, both controls and cases were iodine deficient (85% and 83%, respectively).
Furthermore, dietary iodine was deficient in 23% of controls and 36% of cases. In cases, there was a positive association
between UIC levels and serum thyroid stimulating hormone (r = 0.405, p < 0.01) and a negative association with serum fT4 (r = −0.358, p < 0.01). Serum Tg antibody titers were also positively associated with dietary iodine (r = 0.328, p < 0.05). Patients with elevated serum autoantibodies had lower UIC and dietary iodine than those with normal serum autoantibodies.
UIC was associated with dietary goitrogens including turnip (r = 0.280, p < 0.05) and pine (r = 0.289, p < 0.05) among cases. Iodine deficiency is common and the consumption of dietary goitrogens is high among euthyroid and hypothyroid
subjects living in Jeddah. 相似文献
5.
Xiaojie Li Guanpin Yang Yuanyuan Shi Yizhou Cong Shi Che Shancun Qu Zhiling Li 《Journal of applied phycology》2008,20(6):1097-1102
Eighteen microsatellite markers were used to determine the genetic distances between the parental gametophyte clones of 14
Laminaria hybrids, which were then used to establish a linear relationship with the heterosis (hybrid vigor) of economic traits including
yield, mean blade try weight, mean blade fresh weight, blade length, blade width and mean blade thickness using regression
analysis. Significant regression was found between the genetic distance (x) and the heterosis (y) of yield (y = 115.10x − 77.97,
r = 0.8151, p = 0.00038), mean blade dry weight (y = 115.23x −77.97, r = 0.8154, p = 0.00038), mean blade fresh weight (y = 100.08x − 57.85, r = 0.7306, p = 0.0030) and blade length (y = 204.11x − 46.77, r = 0.6963, p = 0.00566). The prediction of the heterosis of Laminaria hybrids with the genetic distance between parental gametophyte clones will facilitate the selection of elite Laminaria hybrids by avoiding the time-consuming and labor-intensive trait evaluation of a large number of hybridization combinations. 相似文献
6.
Seifi S Tabandeh MR Nazifi S Saeb M Shirian S Sarkoohi P 《Journal of physiology and biochemistry》2012,68(2):193-203
Available experimental data suggest that adiponectin and thyroid hormones have biological interaction in vivo. However, the
effects of thyroid hormones on adipose adiponectin gene expression in thyroid dysfunction are unclear. We induced hyper- (HYPER)
and hypothyroidism (HYPO) by daily administration of a 12 mg/l of levothyroxine and 250 mg/l of methimazole in drinking water
of rats, respectively, for 42 days. The white adipose tissues and serum sample were taken on days 15, 28, 42 and also 2 weeks
after treatment cessation. Analysis of adiponectin gene expression was performed by real-time PCR and 2−ΔΔct method. The levels of adipose tissue adiponectin mRNA in the HYPO rats were decreased during the 6-week treatment when compared
to control rats (<0.05) and were increased significantly 2 weeks after HYPO cessation (P < 0.05). This decline in adiponectin gene expression occurred in parallel with a decrease in T3, T4, fT3 and fT4 concentrations
(P < 0.05). In opposite to HYPO rats, adipose adiponectin gene expression was increased in HYPER rats during the 6-week treatment
in parallel with an increase the thyroid hormones concentrations (P < 0.05), and its expression was decreased 2 weeks after HYPER cessation (P < 0.05). Adiponectin gene expression levels showed significant negative correlations with concentrations of LDL (HYPO; r = −0.806, P = 0.001 and HYPER; r = −0.749, P = 0.002), triglyceride (HYPO; r = −0.825, P = 0.001 and HYPER; r = −0.824, P = 0.001) and significant positive correlations with concentrations of glucose (HYPO; r = 0.674, P = 0.004 and HYPER; r = 0.866, P = 0.001) and HDL (HYPO; r = 0.755, P = 0.001 and HYPER; r = 0.839, P = 0.001). The current study provides evidence that adiponectin gene expression in adipose tissue is regulated by thyroid
hormones at the translation level and that lipid and carbohydrate disturbances in a patient with thyroid dysfunction may be,
in part, due to adiponectin gene expression changes. 相似文献
7.
Reza Amani Somaye Saeidi Zahra Nazari Sorour Nematpour 《Biological trace element research》2010,137(2):150-158
It has been suggested that mood disorders and depressive status may be accompanied by lowered zinc status in the body, and
adequate consumption of zinc increases a general perceived well-being. The main objective of this study was to assess the
correlation between serum zinc concentrations and dietary zinc intakes with depression scores in university female students.
In the first phase, Beck's depression questionnaire was applied in a random sampling of 308 selected 20–25-year-old female
students (one third of total students in Ahvaz Jondi-Shapour University of Medical Sciences Golestan dormitories) to assess
the major depressive disorder (MDD) scales. Then, in the second phase, 23 students who identified as having moderate and severe
depression were selected as the case group, and 23 healthy age matched were chosen as the controls. Each of them completed
a 12-item semiquantitative food frequency questionnaire containing the main food sources of zinc in the usual dietary patterns
and also a 24-h food recall questionnaire to assure the daily zinc intakes. Daily zinc intakes were obtained by multiplying
each portion size by its zinc content using food tables. A 5-ml blood sample was taken for further serum zinc status using
flame atomic absorption spectrophotometry technique. Pearson's r was used to show the correlation between quantitative variables. Both daily zinc intake and serum zinc concentrations of
MDD group were about two thirds of healthy index (p < 0.01). Depressed individuals used to eat lower servings of red meats and chicken as the main food sources of zinc in students'
usual diets (p < 0.001). Consumption of other foods as the sources of zinc was not significantly different in two groups. A linear significant
correlation between dietary zinc intakes and its serum levels was seen in samples (r = 0.62; p < 0.001) and MDD students (r = 0.55; p < 0.001). There was a linear inverse correlation between Beck questionnaire scores and serum zinc concentrations in all of
the investigated students(r = -0.65; p < 0.001) and MDD girls (r = −0.71; p < 0.001). Beck questionnaire scores and diatary zinc intakes were also inversly correlated (r = −0.58; p < 0.001). However, no statistical correlation was seen between these two variables in MDD cases. In depressed female students,
dietary zinc intake is correlated to its serum concentrations; however, the serum zinc levels are inversely correlated to
depression scales. Consumption of the main dietary sources of zinc such as red meats and chicken should be encouraged in young
depressed girls. 相似文献
8.
Krepuska M Szeberin Z Sótonyi P Sarkadi H Fehérvári M Apor A Rimely E Prohászka Z Acsády G 《Cell stress & chaperones》2011,16(3):257-265
It has been previously reported that serum levels of 70-kDa heat shock protein (Hsp70) are elevated in peripheral artery disease.
The aim of the present study was to examine whether increased serum Hsp70 levels are related to the extent of arterial calcification
and standard laboratory parameters of patients with peripheral artery disease, as well as to markers of inflammation (C-reactive
protein), atherosclerosis (homocysteine), and calcification (fetuin-a). One hundred eighty chronic atherosclerotic patients
with significant carotid stenosis and/or lower extremity vascular disease were enrolled in this cross-sectional study. Systemic
atherosclerosis and calcification was assessed by ultrasound (carotid intima–media thickness (IMT), presence of calcification
at the abdominal aorta, carotid and femoral bifurcations, and aortic and mitral cardiac valves). Standard serum markers of
inflammation, diabetes, renal function, ankle-brachial indexes, and traditional risk factors for atherosclerosis were noted.
Serum Hsp70 levels were measured with enzyme-linked immunosorbent assay. Standard laboratory parameters (clinical chemistry),
C-reactive protein (CRP), and homocysteine levels were determined by an autoanalyzer using the manufacturer’s kits. Fetuin-a
levels were measured by radial immunodiffusion. Patients’ median age was 64 (57–71) years, 69% were men, and 34.5% had diabetes.
Serum heat shock protein 70 levels were significantly higher in patients with more severe arterial calcification (p < 0.02) and showed significant positive correlations with serum bilirubin (r = 0.23, p = 0.002) and homocysteine levels (r = 0.18, p = 0.02). Serum Hsp70 did not correlate with body mass index, IMT, CRP, or fetuin-a levels in this cohort. Logistic regression
analysis confirmed the association between sHsp70 and calcification score (OR, 2.189; CI, 1.156–4.144, p = 0.016) and this correlation remained significant (OR, 2.264; CI, 1.021–5.020, p = 0.044) after the adjustment for age, sex, eGFR, smoking, CRP, and homocysteine levels. Our data show that serum Hsp70 levels
correlate with the severity of atherosclerosis in patients with carotid artery disease and chronic lower limb ischemia. These
data support a putative role for plasma Hsp70 in the development of arterial calcification. Nevertheless, further studies
are required to investigate the usefulness of circulating Hsp70 level as a marker of atherosclerotic calcification. 相似文献
9.
Lilla Tamási Anikó Bohács Viola Tamási Balázs Stenczer Zoltán Prohászka János RigóJr. György Losonczy Attila Molvarec 《Cell stress & chaperones》2010,15(3):295-300
Asthma is one of the most common diseases complicating pregnancy and represents a risk factor for several maternal and perinatal
complications. The natural history of asthma is known to change in pregnancy, but very few data are available in the terms
of pathomechanism of this change during gestation. Circulating heat shock protein 70 (Hsp70) levels are decreased in healthy
pregnancy, which might reflect physiological immunotolerance. The aim of our study was to determine the serum levels of Hsp70
in asthmatic women during gestation. Forty pregnant women with bronchial asthma and 40 healthy pregnant women matched for
maternal and gestational age were involved in this case-control study. Serum Hsp70 levels were measured using the ELISA Kit
of R&D Systems. Spirometry and oxygen saturation measurements were performed in asthmatic patients. In asthmatic pregnant
women, an increase of serum Hsp70 levels was observed compared to healthy pregnant women (median (25–75 percentile): 0.44 ng/ml
(0.36–0.53) versus 0.21 ng/ml (0–0.27), p < 0.001). Fetal birth weight of asthmatic mothers was significantly smaller than of healthy controls, but in the normal range
(3,230 g (2,690–3,550) versus 3,550 g (3,450–3,775), p < 0.05). A statistically significant negative correlation between maternal age and serum Hsp70 concentrations (Spearman R = −0.48, p = 0.0018) and a significant positive correlation between gestational age and serum Hsp70 levels (Spearman R = 0.83, p < 0.001) were detected in healthy pregnant women. In conclusion, this study proves an elevation of circulating Hsp70 levels
during asthmatic pregnancy compared to healthy pregnant women. However, further studies are warranted to determine the role
of circulating Hsp70 in the pathogenesis of maternal and perinatal complications of asthma in pregnancy. 相似文献
10.
Tohidi M Ghasemi A Hadaegh F Arbabi S Hosseini Isfahani F 《Biological trace element research》2011,143(2):835-843
This study aims at determining the association between markers of hepatic injury and serum, urinary, and intra-erythrocyte
magnesium concentrations and dietary magnesium intake in obese children and adolescents. In a case–control study, 42 obese
children and adolescents (8–18 years) and 42 sex- and puberty-matched controls were studied. Serum, urinary, and intra-erythrocyte
magnesium levels, indices of insulin sensitivity, and liver enzymes were measured. Dietary magnesium intake was assessed using
a food frequency questionnaire. Obese children and adolescents exhibited insulin resistance as determined by a higher fasting
insulin and the HOMA-IR (p < 0.001) and lower QUICKI indices (p = 0.001); in addition these subjects had significantly higher intra-erythrocyte magnesium (IEM) concentrations, than non-obese
ones (3.99 ± 1.05 vs. 3.35 ± 1.26 mg/dL of packed cell; p = 0.015). Among liver enzymes, only gamma-glutamyl transferase (GGT) was significantly higher in obese than in non-obese
subjects (22.7 ± 9.4 vs. 17.1 ± 7.9 U/l; p = 0.002). A positive association was found between GGT and IEM in both groups; however in multivariate analysis, in obese
subjects, only GGT (p = 0.026) and, in non-obese subjects, only age (p = 0.006) remained as significant predictors of IEM. In conclusion, increased IEM concentration was seen in insulin-resistant
obese children and adolescents; furthermore, serum GGT was associated with IEM, independently of body mass index and HOMA-IR. 相似文献
11.
Sandström ME Siegler JC Lovell RJ Madden LA McNaughton L 《Cell stress & chaperones》2008,13(2):169-175
The purpose of this study was to investigate the alterations in serum heat shock protein (Hsp) 70 levels during a 15-consecutive-day
intermittent heat–exercise protocol in a 29-year-old male ultra marathon runner. Heat acclimation, for the purpose of physical
activities in elevated ambient temperatures, has numerous physiological benefits including mechanisms such as improved cardiac
output, increased plasma volume and a decreased core temperature (T
c). In addition to the central adaptations, the role of Hsp during heat acclimation has received an increasing amount of attention.
The acclimation protocol applied was designed to correspond with the athlete’s tapering period for the 2007 Marathon Des Sables.
The subject (VO2max = 50.7 ml·kg−1·min−1, peak power output [PPO] = 376 W) cycled daily for 90 min at a workload corresponding to 50% of VO2max in a temperature-controlled room (average WBGT = 31.9 ± 0.9°C). Venous blood was sampled before and after each session
for measurement of serum osmolality and serum Hsp70. In addition, T
c, heart rate (HR) and power output (PO) was measured throughout the 90 min to ensure that heat acclimation was achieved during
the 15-day period. The results show that the subject was successfully heat acclimated as seen by the lowered HR at rest and
during exercise, decreased resting and exercising T
c and an increased PO. The heat exercise resulted in an initial increase in Hsp70 concentrations, known as thermotolerance,
and the increase in Hsp70 after exercise was inversely correlated to the resting values of Hsp70 (Spearman’s rank correlation = −0.81,
p < 0.01). Furthermore, the 15-day heat–exercise protocol also increased the basal levels of Hsp70, a response different from
that of thermotolerance. This is, as far as we are aware, the first report showing Hsp70 levels during consecutive days of
intermittent heat exposure giving rise to heat acclimation. In conclusion, a relatively longer heat acclimation protocol is
suggested to obtain maximum benefit of heat acclimation inclusive of both cellular and systemic adaptations. 相似文献
12.
Esposito P Tinelli C Libetta C Gabanti E Rampino T Dal Canton A 《Cell stress & chaperones》2011,16(2):219-224
Autoimmunity to heat shock protein 60 (HSP60) has been related to atherosclerosis. Chlamydia pneumoniae (CP), the most studied infectious agent implicated in promoting atherosclerosis, produces a form of HSP60, which can induce
an autoimmune response, due to high antigenic homology with human HSP60 (hHSP60). In this study, we evaluated the correlations
among anti-hHSP60 antibodies, CP infection, and cardiovascular disease (CVD) in a high-risk population, such as patients undergoing
hemodialysis (HD). Thirty-two patients (67.9 ± 13.9 years; male/female, 23:9) on regular HD were enrolled. Global absolute
cardiovascular risk (GCR) was assessed using the Italian CUORE Project’s risk charts, which evaluate age, gender, smoking
habits, diabetes, systolic blood pressure, and serum cholesterol. The occurrence of cardiovascular events during a 24-month
follow-up was recorded. Seropositivity to CP and the presence of anti-hHSP60 antibodies were tested by specific enzyme-linked
immunosorbent assays. Inflammation was assessed by measurement of C-reactive protein (CRP) serum levels. Fifteen healthy sex
and age-matched (61.9 ± 9.5 years; male/female, 11:4) subjects were the control group. Fifteen of 32 patients resulted seropositive
for CP. CP + patients were older than CP−, while they did not differ for GCR, CRP, and dialytic parameters. CVD incidence
was significantly higher in CP+ (9 CP+ vs 2 CP−, p < 0.05). Cox analysis recognized that the incidence of CVD was independently correlated with seropositivity to CP (HR, 7.59;
p = 0.01; 95% CI = 1.63–35.4). On the other hand, there were no significant differences in anti-hHSP60 levels among CP+, CP−
and healthy subjects: 18.11 μg/mL (14.8–47.8), 31.4 μg/mL (23.2–75.3), and 24.72 μg/mL (17.7–41.1), respectively. Anti-hHSP60
did not correlate to GCR, CRP, and incidence of CVD. In conclusion, our data suggest that anti-hHSP60 autoimmune response
is not related to CP infection and CP-related CVD risk in HD patients. 相似文献
13.
Excessive iodine intake is known to induce hypothyroidism in people who have underlying thyroid disorders. However, few studies
have been performed on subjects with normal thyroid function without a history of autoimmune thyroid disease. We hypothesized
that high iodine intake may cause a subtle change in thyroid function even in subjects with normal thyroid function. We analyzed
337 subjects (64 men and 273 women; mean age, 49 years) who showed normal levels of thyroid peroxidase antibodies (TPO-Ab)
and thyroglobulin antibodies (Tg-Ab) by measuring the urinary iodine excretion, free T4 (FT4), and thyroid-stimulating hormone
(TSH). The results showed urinary iodine excretion had negative correlation with FT4 (γ = −0.11, p = 0.043) and showed a positive trend with TSH (γ = 0.10, p = 0.068). We found that 61.7% of subjects had circulating TPO-Ab within normal reference range. In all subjects, TPO-Ab levels
were negatively correlated with FT4 (γ = −0.17, p = 0.002) and positively with TSH (γ = 0.13, p = 0.021). In conclusion, high iodine intake can negatively affect thyroid hormone levels in subjects with normal thyroid
function. Population-based study will be helpful for further clarification. 相似文献
14.
Paula N. Morgan Francoise Costa Carmen M. Donangelo Janet C. King 《Biological trace element research》1994,42(2):129-142
The aim of this study was to determine whether the postprandial decline in plasma zinc concentration is altered by aging.
Eleven women, between the ages of 65 and 82 yr, participated in two separate experimental protocols: a high carbohydrate breakfast
trial and a fasting trial. Plasma zinc concentrations were measured from blood samples obtained at 8∶00am (baseline fasting) and at 30-min intervals until 1∶00pm during each trial. Following the breakfast meal, plasma zinc concentrations declined 14% from 75±1 to 65±2 μg/dL (p<0.05), reaching a nadir 2.7±0.2 h after the meal. This decline was significantly (p<0.0001) greater than the 3.6% fall observed during the fasting trial. Postprandial changes in the plasma zinc concentrations
were correlated with postprandial changes in serum glucose (r=−0.43,p<0.001), serum insulin (r=−0.17,p<0.01), and serum phosphorus(r=0.32,p<0.005). These data show that plasma zinc concentrations decline following food intake in elderly women in the same manner
as previously described for younger adult women. 相似文献
15.
It is thought that calcium and magnesium may be related to metabolic disorders such as obesity and metabolic syndrome; however,
to date, there have been few studies investigating the association between serum calcium and magnesium levels and metabolic
syndrome in middle-aged male adults. We aimed to investigate the association between serum calcium and magnesium levels and
metabolic syndrome in Korean middle-aged male adults. Study subjects included 213 men aged 30∼60 years. MetS risk score is
determined by adding the number of risk factors, waist circumference, triacylglyceride (TG), HDL cholesterol, glucose, and
blood pressure (BP). The study population was divided into three groups according to the MetS risk score: group I (MetS risk
score ≤1; n = 106), group II (MetS risk score = 2; n = 51), and group III (MetS risk score ≥3; n = 56). The serum Ca, according to increase of MetS risk score, was significantly higher (p < 0.001), and there was no significant difference in serum Mg concentration among the three groups. Subjects with high TG
and high BP had higher serum calcium levels than those without such abnormalities. Subjects with higher glucose had lower
serum magnesium levels than those without such abnormality. The correlation analysis indicated that the serum Ca had positive
correlations with the MetS risk score (r = 0.1769, p < 0.01), serum TG (r = 0.2516, p < 0.001), and DBP (r = 0.2246, p < 0.01). The correlation analysis indicated that the serum Mg had an inverse relationship with serum glucose (r = −0.2404, p < 0.001). In conclusion, serum Ca had positive association with TG and BP, while serum Mg had negative association with serum
glucose after adjusting age and BMI among the middle-aged Korean male adults. 相似文献
16.
Background Circulating heat shock protein 70 (Hsp70) is present in the circulation of healthy individuals and in patients with various
disorders, including chronic heart failure (CHF). However, the source and routes of release of Hsp70 is only partially characterised
in clinical samples.
Aims The purpose of this study was to study the clinical and biological correlates of Hsp70 in a CHF population and, for the first
time, to investigate the association of HspA1B (also known as Hsp70-2) +1267 alleles with serum Hsp70 levels.
Methods A total of 167 patients (123 men, 44 women) with <45% left ventricular ejection fraction (LVEF) were enrolled; serum Hsp70
level was determined by enzyme-linked immunosorbent assay and HspA1B +1267 polymorphism by polymerase chain reaction–restriction fragment length polymorphism.
Results Increased Hsp70 levels were present in patients with severe CHF (NYHA III–IV) as compared to the group of NYHA I–II (p = 0.003). Hsp70 levels correlated with LVEF, NT-proBNP, serum bilirubin, aspartate aminotransferase, alanine aminotransferase,
γGT (p < 0.05) concentrations in patients with severe CHF, although no correlation was observed between Hsp70 and CRP, TNF-α, or
IL-6. HspA1B allele G was associated with higher Hsp70 levels (p = 0.001) in patients in NYHA IV class as compared to carriers of allele A.
Conclusions Serum Hsp70 levels were associated with disease severity in heart failure patients. An interaction with the presence of HspA1B +1267 allele G was observed for Hsp70 concentrations. Hsp70 correlates with markers of heart function and hepatic injury,
but not with signs of inflammation. 相似文献
17.
Abakay A Gokalp O Abakay O Evliyaoglu O Sezgi C Palanci Y Ekici F Karakus A Tanrikulu AC Ayhan M 《Biological trace element research》2012,145(2):151-157
The aim of this study was to investigate the respiratory function disorders that could be related to dust exposure during
the production of copper mine in copper mineworkers (CMWs). The study included 75 male CMWs (mean age, 32.0 ± 7.1 years, 58.6%
smokers) and 75 male age- and smoking status-matched healthy control subjects. Serum Cu level was significantly higher in
the CMW group (0.80 ± 0.62 μg/ml) than the control group (0.60 ± 0.39 μg/ml) (p = 0.017). Significant negative correlations were found between serum Cu level and forced expiratory volume in first second
(r = −0.600; p < 0.001) and between serum Cu level and forced vital capacity (r = −0.593; p = <0.001) in CMWs. Serum Cu level was significantly higher in the restrictive type pulmonary function disorders group (1.36 ± 0.62 μg/ml)
than obstructive type (0.90 ± 0.55 μg/ml) and normal pulmonary function pattern group (0.53 ± 0.43 μg/ml) (p < 0.001). Patients with radiological parenchymal abnormalities had significantly higher serum copper levels than those without
abnormalities (1.53 ± 0.52 vs. 0.71 ± 0.52 μg/ml, respectively; p = 0.002). In conclusion, result of the study has shown a negative association between pulmonary functions disorders and radiological
abnormalities and serum Cu levels in CMWs. 相似文献
18.
J. B. K. Leonard J. F. Norieka B. Kynard S. D. McCormick 《Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology》1999,169(4-5):287-295
To assess the energetics of migration in an anadromous fish, adult American shad (Alosa sapidissima) were swum in a large respirometer at a range of speeds (1.0–2.3 body lengths (BL) s−1, 13–24 °C). Metabolic rate (MO2) was logarithmically related to swimming speed (Bl s−1; r
2 = 0.41, slope = 0.23 ± 0.037) and tailbeat frequency (beats × min−1; r
2 = 0.52, slope = 0.003 ± 0.0003). Temperature had a significant effect on metabolic rate (r
2 = 0.41) with a Q10 of 2.2. Standard metabolic rate (SMR), determined directly after immobilization with the neuroblocker gallamine triethiodide,
ranged from 2.2–6.2 mmolO2 kg−1 h−1 and scaled with mass (W) such that SMR = 4.0 (±0.03)W0.695(±0.15). Comparison of directly determined and extrapolated SMR suggests that swimming respirometry provides a good estimate of SMR
in this species, given the differences in basal activity monitored by the two methods. Overall, American shad metabolic rates
(MO2 and SMR) were intermediate between salmonids and fast-swimming perciforms, including tunas, and may be a result of evolutionary
adaptation to their active pelagic, schooling life history. This study demonstrates variability in metabolic strategy among
anadromous fishes that may be important to understanding the relative success of different migratory species under varying
environmental conditions.
Accepted: 3 March 1999 相似文献
19.
Watanabe A Shimokawa T Moriyama M Komine F Amaki S Arakawa Y Ra C 《Immunogenetics》2006,58(12):937-946
Fc receptor for IgA (FcαR, CD89) is capable of triggering IgA-mediated immune responses to pathogens and has been proposed to function in circulating IgA clearance. Because inheritable variations modifying individual immune responses or immunoglobulin catabolism may affect the chronicity of viral infection, we investigated whether promoter polymorphisms of the FcαR gene (FCAR) affect chronic hepatitis C virus (HCV) infection and its disease progression. The two −311T/C and −142T/C single-nucleotide polymorphisms (SNPs) were studied by direct DNA sequencing in 177 Japanese patients with chronic hepatitis C (CHC). Both −311CC and −142CC genotypes were more frequent in CHC patients (15.9 and 18.6%) compared with 210 healthy controls (5.7 and 10.0%) [p = 0.001, odds ratio (OR) = 3.10, 95% confidence interval CI) = 1.53–6.30 and p = 0.014, OR = 2.06, 95% CI = 1.14–3.72, respectively], and were associated with infection with HCV genotype 2a/2b (p = 0.019 and p = 0.005, respectively). Conversely, −311CC and −142CC were decreased in 59 patients at advanced stages of disease as assessed on the basis of hepatic fibrosis markers such as decreased platelet count (PLT) ( < 150,000/μl) (5.1 and 8.5%) compared with 91 patients with normal PLT ( ≥ 150,000/μl) (24.2 and 26.4%) (p = 0.006 and p = 0.005, respectively). Moreover, among the patients with normal PLT (but not with decreased PLT), −311CC or −142CC was significantly associated with decreased serum IgA levels (p = 0.023 or p = 0.007, respectively). These results suggest that the FCAR promoter SNPs may be related to chronic HCV infection and disease progression in Japanese CHC, which might be explained by altered FcαR expression affecting IgA-mediated immune responses and/or IgA catabolism. 相似文献
20.
Ozkaya M Sahin M Cakal E Gisi K Bilge F Kilinc M 《Biological trace element research》2009,128(2):144-151
The present study was conducted to evaluate the serum selenium levels in first-degree relatives of diabetic patients (FDR)
according to controls. Insulin resistance, serum lipid levels, inflammation markers, and blood pressure were also studied
in these patients. Serum levels of selenium in FDR were significantly lower than control group (74.65 ± 5.9 vs 88.7 ± 8.7 μg/dl,
p < 0.0001). HsCRP, HOMA-IR, insulin, homocysteine levels were significantly higher in FDR according to the control group (1.32 ± 0.9
vs 0.63 ± 0.4 mg/dL, p < 0.0001; 2.07 ± 0.84 vs 1.51 ± 0.69, p < 0.0001; 9.26 ± 3.8 vs 6.8 ± 2.98 μU/MI, p < 0.0001; 15.7 ± 7.4 vs 11.5 ± 5.1 μmol/L, p < 0.0001, respectively). There was significant correlation between selenium levels and hsCRP (r = − 0.450, p < 0.0001). There was also weak significant correlation also between HOMA-IR and selenium levels (r = −0.227, p = 0.003). There was a correlation between systolic blood pressure and BMI (r = 0.365, p < 0.0001). But there was no correlation between selenium levels and blood pressure or other parameters. HsCRP, HOMA-IR, homocysteine
levels in individuals with selenium levels < 80 μg/L (n = 78) was significantly higher than hsCRP HOMA-IR, homocysteine levels in individuals with selenium levels ≥ 80 (n = 91; 1.23 ± 0.98 vs 0.81 ± 0.76 mg/dL, p < 0.003; 1.99 ± 0.88 vs 1.64 ± 0.74, p < 0.005; 15.0 ± 7.6 vs 12.9 ± 5.7 μmol/L, p < 0.049, respectively). Selenium deficiency may contribute to cardiovascular disease risk in FDR. 相似文献