Genetics education in the People's Republic of China.

The National Education Commission of the People's Republic of China directs all educational course content from kindergarten to graduate level in all disciplines. The study of genetics is thus controlled by the members of the commission, so there is little variation of course offerings from one institution to another. Formal genetics education begins in lower middle school and is expanded somewhat in upper middle school (high school). Middle school marks the end of the formal education for most Chinese students, although many graduates learn the practical aspects of genetics while working in agricultural plant and animal breeding. Students who continue the study of genetics in universities find that course work is concentrated and research is encouraged, although facilities and supplies are limited. On graduation from a university, most students are sent to factories to use their expertise for increasing food production, while a very small percentage of students continue on to graduate school and eventual research and university teaching. The area of human genetics is handled exclusively in medical schools.     

Photosynthesis research in the People's Republic of China1

The first research paper on photosynthesis in China was published by T.T. Li² in 1929. Two photosynthesis laboratories were established in Shanghai and Beijing in the 1950s and the 1960s, respectively. A photophosphorylation `intermediate' was discovered after the energy conversion process was separated into light and dark phases in the 1960s. Since the 1980s, research has accelerated at several different levels through efforts of a large number of scientists in China. This revised version was published online in August 2006 with corrections to the Cover Date.     

Reduction Patterns of Acute Schistosomiasis in the People's Republic of China

Background

Despite significant, steady progress in schistosomiasis control in the People''s Republic of China over the past 50 years, available data suggest that the disease has re-emerged with several outbreaks of acute infections in the early new century. In response, a new integrated strategy was introduced.

Methods

This retrospective study was conducted between Jan 2005 and Dec 2012, to explore the effectiveness of a new integrated control strategy that was implemented by the national control program since 2004.

Results

A total of 1,047 acute cases were recorded between 2005 and 2012, with an annual reduction in prevalence of 97.7%. The proportion of imported cases of schistosomiasis was higher in 2011 and 2012. Nine clusters of acute infections were detected by spatio-temporal analysis between June and November, indicating that the high risk areas located in the lake and marshland regions.

Conclusion

This study shows that the new integrated strategy has played a key role in reducing the morbidity of schistosomiasis in the People''s Republic of China.     

The current status of cardiovascular surgery in the People's Republic of China

Dr. David Bregman was invited to participate in a thirteen-physician American Teaching Delegation led by Dr. Tsung O. Cheng, Professor of Medicine at George Washington University Medical Center in Washington, D.C. The trip was sponsored by the American College of Physicians. Deputy Director of the delegation was Dr. Samuel Asper, Deputy Executive Vice President of the American College of Physicians and Professor of Medicine at Johns Hopkins University. The American Teaching Delegation was the first of its kind to be invited to lecture and impart new medical-surgical techniques throughout the People's Republic of China. The trip lasted approximately one month, from September to October, 1979, and included the September 30 to October 1 celebrations in Peking commemorating the 30th Anniversary of the founding of the People's Republic of China. Principal cities visited were Peking and Shanghai, as well as Chengtu, Chungking, and Wuhan. Dr. Bregman demonstrated, for the first time in the People's Republic of China, intraaortic balloon pumping, a new percutaneous intraaortic balloon, and other cardiac assist techniques.     

The one-child family: international patterns and their implications for the People's Republic of China

China's Campaign for 1-child families began in 1979 with the goal of limiting its population to 1.2 billion by the year 2000. The 1982 Census indicates that almost 1/2 the mothers between 20 and 29 had had only 1 child. The campaign has aroused considerable interest worldwide because most studies of 1-child families have been based on small samples, often in the US. This study compares the general rates of 1 child families in China and 60 other countries. Data were gathered from national censuses, UN demographic yearbooks, and some World Fertility Surveys and other sources. China's current 1-child family rate (12.5%) is relatively low compared with some developed countries, e.g. Hungary (25.0%), and the US (17.1%). 80% of countries have rates in the 10.0%-19.9% range. For less developed countries (LDCs), rates increase rapidly to age 20-24, declining slowly until age 40. Chinese rates are slightly less at most ages than the average LDC. In more developed countries, the decline begins after age group 25-29. The difference is likely to be due to the later age of marriage and longer birth intervals of women in the developed countries. The % of completed single child families (indicated by rates for women in their later reproductive years) for China are quite low compared to the other developing and developed countries. Despite publicity surrounding the China campaign, China has a considerable distance to go to approach developed nations such as Hungary and Romania.     

Some developments in mathematical demography and their application to the People's Republic of China

Some new results in mathematical demography with applications to the population analysis of the People's Republic of China are summarized. Based on discrete and continuous population equations, most demographic indices are reconstructed in this paper as functionals on the space of solutions to population equation. Some formulae and estimated values of life expectancy and other indexes are listed. A stability theorem for population systems is presented.     

Oltipraz chemoprevention trial in Qidong, People's Republic of China: unaltered oxidative biomarkers

Aflatoxin, which leads to formation of carcinogen-DNA adducts as well as oxidized DNA, is a well-known risk factor for development of hepatocellular carcinoma. The aim of the present study was to investigate if the chemopreventive agent oltipraz had an effect on DNA oxidation measured as oxidized guanine derivatives in urine among healthy individuals living in a region of China at high risk of exposure to aflatoxin and development of hepatocellular carcinoma. Two hundred thirty-three healthy residents of Qidong, PRC, were randomized to 8 weeks treatment with placebo, oltipraz 125 mg daily, or oltipraz 500 mg weekly, with a subsequent 8-week follow-up period. Urine samples were collected as overnight voids. Samples collected 4 weeks into the treatment period and 6 weeks into the follow-up period were analyzed for oxidized guanine derivatives with a HPLC-MS/MS method. A repeated-measures analysis of variance showed no significant differences between the randomization groups regarding changes in oxidized guanine derivatives. In the present double-blind, randomized, placebo-controlled trial performed among healthy individuals, oltipraz had no major effect on oxidative DNA damage. Mechanisms other than prevention of oxidative DNA damage may be of higher importance when oltipraz is used as a chemopreventive agent in humans.     

Combining genetics and population history in the study of ethnic diversity in the People's Republic of China

Genomic data have increasingly been used to complement linguistic, archeological, and anthropological evidence in reconstructing the origins and migratory patterns of modern humans. East Asia is a particular hotspot of human migration, especially mainland China, where a large number of human fossils have been unearthed and more than 20% of the world's population now resides. There are 56 officially recognized ethnic populations (minzu) in China. In the present study we investigated the ancestry and genetic diversity of nine populations: the majority Han of Liaoning Province; the Miao, Yao, Kucong, and Tibetan communities of Yunnan Province in southwest China; and four Muslim populations, the Hui, Bonan, Dongxiang, and Sala from central and northern China. We used both biparental and uniparental markers to determine patterns of diversity at autosomal, mitochondrial, and Y-chromosome loci. The study populations displayed several paternal origins but restricted maternal ancestries. From the Y-chromosome data in particular, major demographic changes, such as the Neolithic population expansion and more recent historical events including migration along the Silk Road, could be inferred. Specific aspects of the internal structure and organization of the study populations, including endogamy and consanguinity, were uncovered using autosomal markers. However, we encountered interpretive problems in terms of the definition of the present-day ethnic study populations in China, which appear to reflect past and present political as well as genetic influences.     

Predominance of Fast-Growing Rhizobium japonicum in a Soybean Field in the People's Republic of China

Soybean rhizobia were isolated from two soils with different cropping histories from Hubei province in central China. The first, from Honghu county, has been under soybean cultivation for decades. All of the isolates obtained from nodules on soybeans growing in this soil were fast-growing, acid-producing rhizobia. However, slow-growing, alkali-producing isolates were obtained at higher dilutions of the same soil. The second soil, from Wuchang county, has been under rice cultivation with no record of previous soybean cultivation. All of the soybean rhizobia recovered from this soil, and at higher dilutions of the soil, were typical slow-growing, alkali-producing isolates. The isolates from both soils were grouped by using intrinsic antibiotic resistance, gel immunodiffusion, and fluorescent-antibody procedures. Representative isolates were tested for symbiotic effectiveness with four soybean cultivars (Peking, Davis, Williams, and Ai Jiao Zao) in a pot experiment. There were significant cultivar-rhizobial interactions. Moreover, on each cultivar, there was at least one fast-growing isolate among these new rhizobia that was as effective as the highly effective slow-growing reference strain USDA 110.     

Predominance of Fast-Growing Rhizobium japonicum in a Soybean Field in the People's Republic of China

Soybean rhizobia were isolated from two soils with different cropping histories from Hubei province in central China. The first, from Honghu county, has been under soybean cultivation for decades. All of the isolates obtained from nodules on soybeans growing in this soil were fast-growing, acid-producing rhizobia. However, slow-growing, alkali-producing isolates were obtained at higher dilutions of the same soil. The second soil, from Wuchang county, has been under rice cultivation with no record of previous soybean cultivation. All of the soybean rhizobia recovered from this soil, and at higher dilutions of the soil, were typical slow-growing, alkali-producing isolates. The isolates from both soils were grouped by using intrinsic antibiotic resistance, gel immunodiffusion, and fluorescent-antibody procedures. Representative isolates were tested for symbiotic effectiveness with four soybean cultivars (Peking, Davis, Williams, and Ai Jiao Zao) in a pot experiment. There were significant cultivar-rhizobial interactions. Moreover, on each cultivar, there was at least one fast-growing isolate among these new rhizobia that was as effective as the highly effective slow-growing reference strain USDA 110.     

The mammals of the Mongolian People's Republic

The mammals of the Mongolian People's Republic are reviewed, their current status and distribution are summarized and distribution maps are provided.     

Endotoxins in baled cottons and airborne dusts in textile mills in the People's Republic of China.

Bulk cotton samples and airborne vertical elutriated cotton dusts were obtained from textile mills in Shanghai, People's Republic of China. Analysis of endotoxin contents revealed that baled cottons which were grown in different countries varied in endotoxin contamination. The two textile mills, which operated at similar overall airborne dust levels, differed markedly in the levels of airborne endotoxins. The data suggest that the biological activity or "toxicity" of airborne cotton dusts may not be correlated directly with gravimetric dust levels.