共查询到20条相似文献,搜索用时 31 毫秒
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Aurelien Dugourd Christoph Kuppe Marco Sciacovelli Enio Gjerga Attila Gabor Kristina B. Emdal Vitor Vieira Dorte B. BekkerJensen Jennifer Kranz Eric.M.J. Bindels Ana S.H. Costa Abel Sousa Pedro Beltrao Miguel Rocha Jesper V. Olsen Christian Frezza Rafael Kramann Julio SaezRodriguez 《Molecular systems biology》2021,17(1)
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Identification of sparsely distributed clusters of cis-regulatory elements in sets of co-expressed genes 总被引:4,自引:0,他引:4 下载免费PDF全文
Kreiman G 《Nucleic acids research》2004,32(9):2889-2900
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A graph-based approach to systematically reconstruct human transcriptional regulatory modules 总被引:2,自引:0,他引:2
Yan X Mehan MR Huang Y Waterman MS Yu PS Zhou XJ 《Bioinformatics (Oxford, England)》2007,23(13):i577-i586
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Robert Carreras-Torres Suman Kundu Daniela Zanetti Esther Esteban Marc Via Pedro Moral 《PloS one》2014,9(5)
Coronary artery disease (CAD) mortality and morbidity is present in the European continent in a four-fold gradient across populations, from the South (Spain and France) with the lowest CAD mortality, towards the North (Finland and UK). This observed gradient has not been fully explained by classical or single genetic risk factors, resulting in some cases in the so called Southern European or Mediterranean paradox. Here we approached population genetic risk estimates using genetic risk scores (GRS) constructed with single nucleotide polymorphisms (SNP) from nitric oxide synthases (NOS) genes. These SNPs appeared to be associated with myocardial infarction (MI) in 2165 cases and 2153 controls. The GRSs were computed in 34 general European populations. Although the contribution of these GRS was lower than 1% between cases and controls, the mean GRS per population was positively correlated with coronary incidence explaining 65–85% of the variation among populations (67% in women and 86% in men). This large contribution to CAD incidence variation among populations might be a result of colinearity with several other common genetic and environmental factors. These results are not consistent with the cardiovascular Mediterranean paradox for genetics and support a CAD genetic architecture mainly based on combinations of common genetic polymorphisms. Population genetic risk scores is a promising approach in public health interventions to develop lifestyle programs and prevent intermediate risk factors in certain subpopulations with specific genetic predisposition. 相似文献
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