Special Issue on “RNA Epigenetics”

<正>We are very pleased to announce a special issue,to be published in Fall 2017,on"RNA Epigenetics"in the journal Genomics,ProteomicsBioinformatics(GPB).RNAs are life’s essential molecules with diverse functions.The identification and functional studies of multiple types of non-coding RNAs have been a major focus of life science research during the past decade.Moreover,diversified chemical modifications as well as structural     

Special Issue on “RNA Epigenetics”

<正>We are very pleased to announce a special issue,to be published in the fall of 2017,on‘‘RNA Epigenetics’’in the journal Genomics,ProteomicsBioinformatics(GPB).RNAs are life’s essential molecules with diverse functions.The identification and functional studies of multiple types of non-coding RNAs have been a major focus of life science research     

Special Issue on “RNA Epigenetics”

<正>We are very pleased to announce a special issue,to be published in the spring of 2018,on‘‘RNA Epigenetics’’in the journal Genomics,ProteomicsBioinformatics(GPB).RNAs are life’s essential molecules with diverse functions.The identification and functional studies of multiple types of non-coding RNAs have been a major focus of life science research     

Special Issue on “RNA Epigenetics”

正We are very pleased to announce a special issue,to be published in the spring of 2018,on‘‘RNA Epigenetics’’in the journal Genomics,ProteomicsBioinformatics(GPB).RNAs are life’s essential molecules with diverse functions.The identification and functional studies of multiple types of non-coding RNAs have been a major focus of life science research     

Special Issue on “RNA Epigenetics”

正We are very pleased to announce a special issue,to be published in Summer 2017,on "RNA Epigenetics" in the journal Genomics,ProteomicsBioinformatics(GPB).RNAs are life's essential molecules with diverse functions.The identification and functional studies of multiple types of non-coding RNAs have been a major focus of life science research during the past decade.Moreover,diversified chemical modifications as well as structural     

Special Issue on “RNA Epigenetics”

<正>We are very pleased to announce a special issue,to be published in Summer 2017,on‘‘RNA Epigenetics’’in the journal Genomics,ProteomicsBioinformatics(GPB).RNAs are life’s essential molecules with diverse functions.The identification and functional studies of multiple types of non-coding RNAs have been a major focus of life science research during the past decade.Moreover,diversified chemical modifications as well as structural     

Special Issue on ‘‘RNA Epigenetics”

正We are very pleased to announce a special issue,to be published in April 2017,on‘‘RNA Epigenetics’’in the journal Genomics,ProteomicsBioinformatics(GPB).RNAs are life’s essential molecules with diverse functions.The identification and functional studies of multiple types of non-coding RNAs have been a major focus of life science research     

Special Issue on “RNA Epigenetics”

正We are very pleased to announce a special issue,to be published in April 2017,on‘‘RNA Epigenetics’’in the journal Genomics,ProteomicsBioinformatics(GPB).RNAs are life’s essential molecules with diverse functions.The identification and functional studies of multiple types of non-coding RNAs have been a major focus of life science research     

Special Issue on “RNA Epigenetics”

正We are very pleased to announce a special issue,to be published in April 2017,on‘‘RNA Epigenetics’’in the journal Genomics,ProteomicsBioinformatics(GPB).RNAs are life’s essential molecules with diverse functions.The identification and functional studies of multiple types of non-coding RNAs have been a major focus of life science research     

Special Issue on “RNA Epigenetics”

正We are very pleased to announce a special issue,to be published in April 2017,on‘‘RNA Epigenetics’’in the journal Genomics,ProteomicsBioinformatics(GPB).RNAs are life’s essential molecules with diverse functions.The identification and functional studies of multiple types of non-coding RNAs have been a major focus of life science research during the past decade.Moreover,diversified chemical modifications as well as structural     

Special Issue on "RNA Epigenetics"

正We are very pleased to announce a special issue,to be published in April 2017,on‘‘RNA Epigenetics’’in the journal Genomics,ProteomicsBioinformatics(GPB).RNAs are life’s essential molecules with diverse functions.The identification and functional studies of multiple types of non-coding RNAs have been a major focus of life science research during the past decade.Moreover,diversified chemical modifications as well as structural     

Small RNAs in pollen

In plants, each pollen mother cell undergoes two rounds of cell divisions to form a mature pollen grain, which contains a vegetative cell(VC) and two sperm cells(SC). As a companion cell, the VC carries the SCs to an ovule by germinating a pollen tube. In-depth sequencing analyses of mature pollen showed that micro RNAs(mi RNAs) and short interfering RNAs(si RNAs) are present in both the VC and SCs. Additionally, epigenetically-regulated transposable elements(TEs) are reactivated in the VC and these TE m RNAs are further processed into 21-nt epigenetically reactivated si RNA(easiR NA) in SCs, which prevent 24-nt si RNA accumulation and sequester mi RNA loading. Small RNAs are thought to move from the VC to SCs, where they regulate gene expression and reinforce TE silencing. Here, we summarize current knowledge of the biogenesis and function of mi RNAs, si RNAs, and easi RNAs in pollen, emphasizing how these different small RNAs coordinately contribute to sperm cell formation and TE silencing.     

The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility

PIWI-clade proteins harness pi RNAs of 24–33 nt in length. Of great puzzles are how PIWI-clade proteins incorporate pi RNAs of different sizes and whether the size matters to PIWI/pi RNA function. Here we report that a PIWI-Ins module unique in PIWIclade proteins helps define the length of pi RNAs. Deletion of PIWI-Ins in Miwi shifts MIWI to load with shorter pi RNAs and causes spermiogenic failure in mice, demonstrating the functional importance of this regulatory module. Mechanistically, we sh...     

The dichotomy of p53 regulation by noncoding RNAs

The p53 tumor suppressor gene is the most frequently mutated gene in cancer. Significant progress has been made to discern the im- portance of p53 in coordinating cellular responses to DNA damage, oncogene activation, and other stresses. Noncoding RNAs are RNA molecules functioning without being translated into proteins. In this work, we discuss the dichotomy of p53 regulation by noncoding RNAs with four unconventional questions. First, is overexpression of microRNAs responsible for p53 inactivation in the absence of p53 mutation？ Second, are there somatic mutations in the noncoding regions of the p53 gene？ Third, is there a germline mutant in the non- coding regions of the p53 gene that predisposes carriers to cancer？ Fourth, can p53 activation mediated by a noncoding RNA mutation cause cancer？ This work highUghts the prominence of noncoding RNAs in p53 dysregutation and tumorigenesis.     

Endogenous Small RNA Clusters in Plants

In plants, small RNAs（sRNAs） usually refer to non-coding RNAs（ncRNAs） with lengths of 20–24 nucleotides. sRNAs are involved in the regulation of many essential processes related to plant development and environmental responses. sRNAs in plants are mainly grouped into microRNAs（miRNAs） and small interfering RNAs（siRNAs）, and the latter can be further classified into trans-acting siRNAs（ta-siRNAs）, repeat-associated siRNAs（ra-siRNAs）, natural anti-sense siRNAs（nat-siRNAs）, etc. Many sRNAs exhibit a clustered distribution pattern in the genome. Here, we summarize the features and functions of cluster-distributed sRNAs, aimed to not only provide a thorough picture of sRNA clusters（SRCs） in plants, but also shed light on the identification of new classes of functional sRNAs.