Special Issue on “Microbiome and Health”

<正>The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions to a special issue(to be published in the fall of 2017)on the topic of‘‘Microbiome and Health’’.In the era of precision medicine,the human‘‘2nd genome’’,namely the human microbiome,is of increasing interest worldwide.Firstly,the human microbiome has been linked to various     

Special Issue on “Microbiome and Health”

正The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions to a special issue(to be published in the fall of 2017)on the topic of‘‘Microbiome and Health’’.In the era of precision medicine,the human‘‘2ndgenome’’,namely the human microbiome,is of increasing interest worldwide.Firstly,the human microbiome has been linked to various     

Special Issue on “Microbiome and Health”

正The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions to a special issue(to be published in the fall of 2017)on the topic of‘‘Microbiome and Health’’.In the era of precision medicine,the human‘‘2ndgenome’’,namely the human microbiome,is of increasing interest worldwide.Firstly,the human microbiome has been linked to various diseases including metabolic diseases,cancers,heart diseases,or brain disorders,and autoimmune     

Special Issue on “Microbiome and Health”

<正>The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions to a special issue(to be published in the summer of 2018)on the topic of‘‘Microbiome and Health’’.In the era of precision medicine,the human‘‘2~(nd) genome’’,namely the human microbiome,is     

Special Issue on “Microbiome and Health”

正The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions to a special issue(to be published in the fall of 2018)on the topic of‘‘Microbiome and Health’’.In the era of precision medicine,the humannamely the human microbiome,is of increasing interest worldwide.Firstly,the human microbiome has been linked to various diseases including metabolic diseases,cancers,heart diseases,or brain disorders,and autoimmune diseases.Secondly,changes in the microbiome are known or hypothesized to be proxies for environmental or host phenotypical changes.Thirdly,the rational alteration of disturbed human     

Special Issue on “Microbiome and Health”

<正>The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions to a special issue(to be published in the Fall of 2017)on the topic of"Microbiome and Health".In the era of precision medicine,the human"2ndgenome",namely the human microbiome,is of increasing interest worldwide.Firstly,the human microbiome has been linked to various diseases including metabolic diseases,cancers,heart diseases,or brain disorders,and autoimmune diseases.Secondly,changes in the microbiome are known or hypothesized to be proxies for     

Special Issue on “Microbiome and Health”

正The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions to a special issue(to be published in the fall of 2018)on the topic of"Microbiome and Health".In the era of precision medicine,the human"2ndgenome",namely the human microbiome,is of increasing interest worldwide.Firstly,the human microbiome has been linked to various diseases including metabolic diseases,cancers,heart diseases,or brain disorders,and autoimmune diseases.Secondly,changes in the microbiome are known or hypothesized to be proxies for     

Special Issue on “Microbiome and Health”

正The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions to a special issue(to be published in the Fall of 2017)on the topic of"Microbiome and Health".In the era of precision medicine,the human "2ndgenome",namely the human microbiome,is of increasing interest worldwide.Firstly,the human microbiome has been linked to various diseases including metabolic diseases,cancers,heart diseases,or brain disorders,and autoimmune     

Special Issue on “Microbiome and Health”

<正>The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions to a special issue(to be published in the summer of 2018)on the topic of"Microbiome and Health".In the era of precision medicine,the human "2~(nd) genome",namely the human microbiome,is of     

The Fast Track for Microbiome Research

The microbiome research is undoubtedly one of the most popular topics in biomedical research areas.This is not without reason:given that microbiome is found to be linked with and sometime causes chronic diseases and even cancers,it has become more and more obvious that microbiome plays crucial roles in human health and the surrounding environments.     

An Improved Methodology to Overcome Key Issues in Human Fecal Metagenomic DNA Extraction

Microbes are ubiquitously distributed in nature, and recent culture-independent studies have highlighted the significance of gut microbiota in human health and disease. Fecal DNA is the primary source for the majority of human gut microbiome studies. However, further improvement is needed to obtain fecal metagenomic DNA with sufficient amount and good quality but low host genomic DNA contamination. In the current study, we demonstrate a quick, robust, unbiased,and cost-effective method for the isolation of high molecular weight(23 kb) metagenomic DNA(260/280 ratio 1.8) with a good yield(55.8 ± 3.8 ng/mg of feces). We also confirm that there is very low human genomic DNA contamination(eubacterial: human genomic DNA marker genes = 2~(27.9):1) in the human feces. The newly-developed method robustly performs for fresh as well as stored fecal samples as demonstrated by 16 S r RNA gene sequencing using 454 FLX+.Moreover, 16 S r RNA gene analysis indicated that compared to other DNA extraction methods tested, the fecal metagenomic DNA isolated with current methodology retains species richnessand does not show microbial diversity biases, which is further confirmed by q PCR with a known quantity of spike-in genomes. Overall, our data highlight a protocol with a balance between quality,amount, user-friendliness, and cost effectiveness for its suitability toward usage for cultureindependent analysis of the human gut microbiome, which provides a robust solution to overcome key issues associated with fecal metagenomic DNA isolation in human gut microbiome studies.     

Human Pharyngeal Microbiome May Play A Protective Role in Respiratory Tract Infections

The human pharyngeal microbiome, which resides at the juncture of digestive and respiratory tracts, may have an active role in the prevention of respiratory tract infections, similar to the actions of the intestinal microbiome against enteric infections. Recent studies have demonstrated that the pharyngeal microbiome comprises an abundance of bacterial species that interacts with the local epithelial and immune cells, and together, they form a unique micro-ecological system. Most of the microbial species in microbiomes are obligate symbionts constantly adapting to their unique surroundings. Indigenous commensal species are capable of both maintaining dominance and evoking host immune responses to eliminate invading species. Temporary damage to the pharyngeal microbiome due to the impaired local epithelia is also considered an important predisposing risk factor for infections. Therefore, reinforcement of microbiome homeostasis to prevent invasion of infection-prone species would provide a novel treatment strategy in addition to antibiotic treatment and vaccination. Hence continued research efforts on evaluating probiotic treatment and developing appropriate procedures are necessary to both prevent and treat respiratory infections.     

A stage—specific protein factor binding to a CACCC motif in both human β—globin gene promoter and 5‘—HS2 region

The DNaseI hypersensitive site 2 (HS2) of human β-globin locus control region(LCR) is required for the high level expression of human β-globin genes.In the present study,a stage-specific protein factor (LPF-β) was identified in the nuclear extract prepared from mouse fetal liver at d 18 of gestation,which could bind to the HS2 region of human β-globin LCR.We also found that the shift band of LPF-β factor could be competed by human β-globin promoter.However,it couldn‘t be competed by human ε-globin promoter or by human ^Aγ-globin promoter.Furthermore,our data demonstrated that the binding-sequence of LPF-β factor is 5‘CACACCCTA 3‘,which is located at the HS2 region of β-LCR(from-10845 to-10853 bp)and human β-globin promoter(from-92 to -84 bp).We speculated that these regions containing the CACCC box in both the human β-globin promoter and HS2 might function as stage selector elements in the regulation of human β-globin switching and the LPF-β factor might be a stage-specific protein factor involved in the regulation of human β-globin gene expression.     

Special Issue on “Big Data and Precision Medicine”

<正>The journal Genomics ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue on the topic of‘‘Big Data and Precision Medicine’’to be published in the spring of 2016.For many complex diseases,the traditional‘‘one drug for one disease’’scenario may soon become history.The new concept of‘‘precision medicine’’will heavily rely on the     

Special Issue on ‘‘Big Data and Precision Medicine”

<正>The journal Genomics ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue on the topic of‘‘Big Data and Precision Medicine’’to be published in the spring of 2016.For many complex diseases,the traditional‘‘one drug for one disease’’scenario may soon become history.The new concept of‘‘precision medicine’’will heavily rely on the     

Special Issue on ‘‘Big Data and Precision Medicine'

<正>The journal Genomics ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue on the topic of‘‘Big Data and Precision Medicine’’to be published in the spring of 2016.For many complex diseases,the traditional‘‘one drug for one disease’’scenario may soon become history.The new concept of‘‘precision medicine’’will heavily rely on the     

Special Issue on “Big Data in Brain Science”

<正>The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the Winter of 2017)on the topic of‘‘Big data in brain science’’.It took 15 years,3 billion USD,and thousands of top scientists from all over the world to     

Special Issue on “Big Data in Brain Science”

<正>The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the summer of 2018)on the topic of‘‘Big data in brain science’’.It took 15 years,3 billion USD,and thousands of top scientists from all over the world to     

Special Issue on “Big Data in Brain Science”

<正>The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the winter of 2017)on the topic of‘‘Big data in brain science’’.It took 15 years,3 billion USD,and thousands of top scientists from all over the world to