Author Keywords: Thermal conductivity; bioheat transfer; kidney, in vitro; tissue H2O content; rabbit 相似文献
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1.
In the paper the numerical analysis of thermal processes proceeding in the biological tissue is presented. The tissue is subjected to the external heat flux and 2D problem is taken into account. In order to determine the influence of variations of thermophysical parameters of tissue on the value of Arrhenius injury integral the direct approach of sensitivity analysis is applied. On the basis of tissue damage fraction the thermal injury formation process is analysed. At the stage of numerical realization the boundary element method is used. In the final part of the paper the example of numerical simulation is shown. 相似文献
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Recently we showed that the Pennes bioheat transfer equation was not adequate to quantify mm wave heating of the skin at high blood flow rates. To do so, it is necessary to incorporate an \"effective\" thermal conductivity to obtain a hybrid bioheat equation (HBHE). The main aim of this study was to determine the relationship between non-specific tissue blood flow in a homogeneous unilayer model and dermal blood flow in multilayer models providing that the skin surface temperatures before and following mm wave exposure were the same. This knowledge could be used to develop multilayer models based on the fitting parameters obtained with the homogeneous tissue models. We tested four tissue models consisting of 1-4 layers and applied the one-dimensional steady-state HBHE. To understand the role of the epidermis in skin models we added to the one- and three-layer models an external thin epidermal layer with no blood flow. Only the combination of models containing the epidermal layer was appropriate for determination of the relationship between non-specific tissue and dermal blood flows giving the same skin surface temperatures. In this case we obtained a linear relationship between non-specific tissue and dermal blood flows. The presence of the fat layer resulted in the appearance of a significant temperature gradient between the dermis and muscle layer which increased with the fat layer thickness. 相似文献
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Ewa Majchrzak 《Molecular & cellular biomechanics : MCB》2013,10(3):201-232
Heat transfer processes proceeding in the living organisms are described by the different mathematical models. In particular, the typical continuous model of bioheat transfer bases on the most popular Pennes equation, but the Cattaneo-Vernotte equation and the dual phase lag equation are also used. It should be pointed out that in parallel are also examined the vascular models, and then for the large blood vessels and tissue domain the energy equations are formulated separately.In the paper the different variants of the boundary element method as a tool of numerical solution of bioheat transfer problems are discussed. For the steady state problems and the vascular models the classical BEM algorithm and also the multiple reciprocity BEM are presented. For the transient problems connected with the heating of tissue, the various tissue models are considered for which the 1st scheme of the BEM, the BEM using discretization in time and the general BEM are applied.Examples of computations illustrate the possibilities of practical applications of boundary element method in the scope of bioheat transfer problems. 相似文献
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We consider the thermal response of the body to radiofrequency (RF) energy, with emphasis on partial-body exposure, to assess potential thermal hazards. The thermal analysis is based on Pennes' bioheat equation. In this model, the thermal response is governed by two time constants. One (τ1) pertains to heat convection by blood flow and is (for physiologically normal perfusion rates) on the order of 3 min. The second (τ2) characterizes heat conduction, and varies as the square of a distance that characterizes the spatial extent of the heating. We examine three idealized cases. The first is a region of tissue with an insulated surface, subject to irradiation with an exponentially decreasing SAR, which models a large surface area of tissue exposed to microwaves. The second is a region of tissue in contact with a hemispherical electrode that passes current into it, which models exposure from contact with a conductor. The third is a region of tissue with an insulated surface, subject to heating from a dipole located close to it. In all three cases, we estimate the maximum steady-state temperature increase as a function of the relevant electrical and thermal parameters and the thresholds for thermal hazard. We conclude that thermal models are a potentially fruitful but underutilized means of analyzing thermal hazards from RF fields. A quantitative analysis of such hazards enables the development of data-based uncertainty factors, which can replace arbitrary “safety factors” in developing exposure limits. Finally, we comment on the need to marry quantitative modeling of data and risk assessment, and to incorporate contemporary approaches to risk assessment into RF standards development. Bioelectromagnetics 20:52–63, 1999. © 1999 Wiley-Liss, Inc. 相似文献
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Kenneth R. Foster Albert Lozano-Nieto Pere J. Riu Thomas S. Ely 《Bioelectromagnetics》1998,19(7):420-428
We consider the thermal response times for heating of tissue subject to nonionizing (microwave or infrared) radiation. The analysis is based on a dimensionless form of the bioheat equation. The thermal response is governed by two time constants: one(τ1) pertains to heat convection by blood flow, and is of the order of 20–30 min for physiologically normal perfusion rates; the second (τ2) characterizes heat conduction and varies as the square of a distance that characterizes the spatial extent of the heating. Two idealized cases are examined. The first is a tissue block with an insulated surface, subject to irradiation with an exponentially decreasing specific absorption rate, which models a large surface area of tissue exposed to microwaves. The second is a hemispherical region of tissue exposed at a spatially uniform specific absorption rate, which models localized exposure. In both cases, the steady-state temperature increase can be written as the product of the incident power density and an effective time constant τeff, which is defined for each geometry as an appropriate function of τ1 and τ2. In appropriate limits of the ratio of these time constants, the local temperature rise is dominated by conductive or convective heat transport. Predictions of the block model agree well with recent data for the thresholds for perception of warmth or pain from exposure to microwave energy. Using these concepts, we developed a thermal averaging time that might be used in standards for human exposure to microwave radiation, to limit the temperature rise in tissue from radiation by pulsed sources. We compare the ANSI exposure standards for microwaves and infrared laser radiation with respect to the maximal increase in tissue temperature that would be allowed at the maximal permissible exposures. A historical appendix presents the origin of the 6-min averaging time used in the microwave standard. Bioelectromagnetics 19:420–428, 1998. © 1998 Wiley-Liss, Inc. 相似文献
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Pere J. Riu Kenneth R. Foster Dennis W. Blick Eleanor R. Adair 《Bioelectromagnetics》1997,18(8):578-583
Human thresholds for skin sensations of warmth were measured at frequencies from 2.45 to 94 GHz. By solving the one-dimensional bioheat equation, we calculated the temperature increase at the skin surface or at a depth of 175 μm at incident power levels corresponding to the observed thresholds. The thermal analysis suggests that the thresholds correspond to a localized temperature increase of about 0.07 °C at and near the surface of the skin. We also found that, even at the highest frequency of irradiation, the depth at which the temperature receptors are located is not a relevant parameter, as long as it is within 0.3 mm of the surface. Over the time range of the simulation, the results of the thermal model are insensitive to blood flow, but sensitive to thermal conduction; and this sensitivity increases strongly with frequency. We conclude with an analysis of the effect of thermal conduction on surface temperature rise, which becomes a dominant factor at microwave frequencies over 10 GHz. Bioelectromagnetics 18:578–583, 1997. © 1997 Wiley-Liss, Inc. 相似文献
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1. 1.|H2O content and local-tissue thermal conductivity were measured in cortex and medulla of 7 freshly-excised rabbit kidneys.
2. 2.|Tissue H2O content and thermal conductivity k (83.4% and 0.516 W m−t K−1, respectively) in the medulla were significantly higher than those (77.7% and 0.475 W m−1 K−1, respectively) measured in the cortex.
3. 3.|Correlations between the measured parameters are made, and the variability of previously-reported measurements of kidney-tissue thermal conductivity is discussed.
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Sundeep Singh 《Electromagnetic biology and medicine》2018,37(1):13-22
The present study aims at proposing a relationship between the coagulation volume and the target tip temperature in different tissues (viz., liver, lung, kidney, and breast) during temperature-controlled radiofrequency ablation (RFA). A 20-min RFA has been modelled using commercially available monopolar multi-tine electrode subjected to different target tip temperatures that varied from 70°C to 100°C with an increment of 10°C. A closed-loop feedback proportional-integral-derivative (PID) controller has been employed within the finite element model to perform temperature-controlled RFA. The coagulation necrosis has been attained by solving the coupled electric field distribution, the Pennes bioheat and the first-order Arrhenius rate equations within the three-dimensional finite element model of different tissues. The computational study considers temperature-dependent electrical and thermal conductivities along with the non-linear piecewise model of blood perfusion. The comparison between coagulation volume obtained from the numerical and in vitro experimental studies has been done to evaluate the aptness of the numerical models. In the present study, a total of 20 numerical simulations have been performed along with 12 experiments on tissue-mimicking phantom gel using RFA device. The study revealed a strong dependence of the coagulation volume on the pre-set target tip temperature and ablation time during RFA application. Further, the effect of target tip temperature on the applied input voltage has been studied in different tissues. Based on the results attained from the numerical study, statistical correlations between the coagulation volume and treatment time have been developed at different target tip temperatures for each tissue. 相似文献
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Siyao Huang 《Computer methods in biomechanics and biomedical engineering》2014,17(15):1696-1704
This study presents an image-based finite element analysis incorporating histological photomicrographs of heart valve tissues. We report stress fields inside heart valve tissues, where heterogeneously distributed collagen fibres are responsible for transmitting forces into cells. Linear isotropic and anisotropic tissue material property models are incorporated to quantify the overall stress distributions in heart valve tissues. By establishing an effective predictive method with new computational tools and by performing virtual experiments on the heart valve tissue photomicrographs, we clarify how stresses are transferred from matrix to cell. The results clearly reveal the roles of heterogeneously distributed collagen fibres in mitigating stress developments inside heart valve tissues. Moreover, most local peak stresses occur around cell nuclei, suggesting that higher stress may be mediated by cells for biomechanical regulations. 相似文献
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激光热疗中,激光与生物组织相互作用研究主要包含两方面：光子在生物组织中的迁移规律,以及光生扫热在生物组织在的传导。对前者的描述主要为,基于传输理论的解析法和Ｍｏｎｔｅ￣Ｃａｒｌｏ模拟,生物组织中光子迁移规律的研究能定量描述组织中的光分布,并进一步获得生物组织中的热分布;考虑到了生物组织特性,所建立了生物组织中温度场分布及变化规律。光子迁移与生物传热理论是研究激光热序不可分割的传热模型,全面描述了生 相似文献
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Lei Cheng Blake Hannaford 《Computer methods in biomechanics and biomedical engineering》2016,19(1):31-40
Minimizing tissue damage and maintaining grasp stability are essential considerations in surgical grasper design. Most past and current research analyzing graspers used for tissue manipulation in minimally invasive surgery is based on in vitro experiments. Most previous work assessed tissue injury and grasp security by visual inspection; only a few studies have quantified it. The goal of the present work is to develop a methodology with which to compute tissue damage magnitude and grasp quality that is appropriate for a wide range of grasper–tissue interaction. Using finite element analysis (FEA), four graspers with varying radii of curvature and four graspers with different tooth sizes were analyzed while squeezing and pulling liver tissue. All graspers were treated as surgical steel with linear elastic material properties. Nonlinear material properties of tissue used in the FEA as well as damage evaluation were derived from previously reported in vivo experiments. Computed peak stress, integrated stress, and tissue damage were compared. Applied displacement is vertical and then horizontal to the tissue surface to represent grasp and retraction. A close examination of the contact status of each node within the grasper–tissue interaction surface was carried out to investigate grasp stability. The results indicate less tissue damage with increasing radius of curvature. A smooth wave pattern reduced tissue damage at the cost of inducing higher percentage of slipping area. This methodology may be useful for researchers to develop and test various designs of graspers. Also it could improve surgical simulator performance by reflecting more realistic tissue material properties and predicting tissue damage for the student. 相似文献
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We investigated the influence of blood perfusion on local heating of the forearm and middle finger skin following 42.25 GHz exposure with an open ended waveguide (WG) and with a YAV mm wave therapeutic device. Both sources had bell-shaped distributions of the incident power density (IPD) with peak intensities of 208 and 55 mW/cm(2), respectively. Blood perfusion was changed in two ways: by blood flow occlusion and by externally applied vasodilator (nonivamide/nicoboxil) cream to the skin. For thermal modeling, we used the bioheat transfer equation (BHTE) and the hybrid bioheat equation (HBHE) which combines the BHTE and the scalar effective thermal conductivity equation (ETCE). Under normal conditions with the 208 mW/cm(2) exposure, the cutaneous temperature elevation (DeltaT) in the finger (2.5 +/- 0.3 degrees C) having higher blood flow was notably smaller than the cutaneous DeltaT in the forearm (4.7 +/- 0.4 degrees C). However, heating of the forearm and finger skin with blood flow occluded was the same, indicating that the thermal conductivity of tissue in the absence of blood flow at both locations was also the same. The BHTE accurately predicted local hyperthermia in the forearm only at low blood flow. The HBHE made accurate predictions at both low and high perfusion rates. The relationship between blood flow and the effective thermal conductivity (k(eff)) was found to be linear. The heat dissipating effect of higher perfusion was mostly due to an apparent increase in k(eff). It was shown that mm wave exposure could result in steady state heating of tissue layers located much deeper than the penetration depth (0.56 mm). The surface DeltaT and heat penetration into tissue increased with enlarging the irradiating beam area and with increasing exposure duration. Thus, mm waves at sufficient intensities could thermally affect thermo-sensitive structures located in the skin and underlying tissue. 相似文献
13.
《Electromagnetic biology and medicine》2013,32(1):8-14
AbstractTo investigate the effects of fat layer on the temperature distribution during microwave atrial fibrillation catheter ablation in the conditions of different ablation time; 3D finite element models (fat layer and no fat layer) were built, and temperature distribution was obtained based on coupled electromagnetic-thermal analysis at 2.45?GHz and 30?W of microwave power. Results shown: in the endocardial ablation, the existence of the fat layer did not affect the shape of the 50?°C contour before 30?s. The increase speed of depth became quite slowly in the model with fat layer after 30?s. When ablation depth needed fixed, there are no significant effect on effectively ablation depth whether fat layer over or not. However, the existence of fat layer makes the temperature lower in the myocardium, and maximum temperature point closer to the myocardium surface. What is more, in the model with fat layer, effective ablation reach lower maximum temperature and the shallower depth of 50?°C contour. But there are larger ablation axial length and transverse width. In this case, doctor should ensure safety of normal cardiac tissue around the target tissue. In the epicardial ablation, the existence of fat layer seriously affects result of the microwave ablation. The epicardial ablation needs more heating time to create lesion. But epicardial ablation can be better controlled in the shape of effective ablation area because of the slowly increase of target variables after the appearing of 50?°C contour. Doctor can choose endocardial or epicardial ablation in different case of clinic requirement. 相似文献
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Although there have been numerous reports in several articles about the viscoelastic properties of biological tissues, no effort has been made to investigate the combined thermal and mechanical behavior of the viscoelastic tissue. At present, the model of thermo-viscoelasticity theory with variable thermal conductivity and rheological properties of the volume is considered to investigate bio-thermo-mechanics behavior in living tissue within the context of the Lord-Shulman theory. The model is applied to a limited thickness, cancerous layer problem. The problem was solved analytically in the transformed domain using Laplace transform as a tool. The exact solution is obtained in the context of transformation Laplace. Numerical results are given and illustrated graphically for the distributions of temperature, displacement, and stress. Some correlations are produced with the results obtained for the absence of the thermal relaxation parameter. The effects of variable thermal and volume materials properties, blood perfusion rate on the behavior of various fields are examined. 相似文献
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Jun Huang;Jinjin Wu;Yuxin Chen;Tongyu Xu;Kehong Wang;Yunfeng Rui; 《Journal of biophotonics》2024,17(2):e202300373
To investigate the influence of laser parameters on the performance of tendon tissue, experiments were conducted and the process of laser-assisted tendon welding was studied. Several conclusions were drawn by analyzing the effects of laser parameters on the tensile strength, microstructure, and collagen content of tendon tissue incisions. The optimal parameters for laser welding tendon tissue were found to be a laser power of 5 W, a scanning speed of 150 mm/s, and a defocus amount of 0 mm, resulting in a laser energy density of 32.164 J/cm2. At these parameters, the percentage of inactivated cells due to thermal damage was only 23.78%, and the tensile strength of the tendon tissue incisions reached 0.61 MPa. Additionally, the collagen content around the incision was measured to be 33.679%, composed of type I and type III collagens, with the latter accounting for 50.714% of the total collagen content. 相似文献
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Ali Vahdati 《Computer methods in biomechanics and biomedical engineering》2013,16(11):1211-1221
Most tissue-engineered cartilage constructs are more compliant than native articular cartilage (AC) and are poorly integrated to the surrounding tissue. To investigate the effect of an implanted tissue-engineered construct (TEC) with these inferior properties on the mechanical environment of both the engineered and adjacent native tissues, a finite element study was conducted. Biphasic swelling was used to model tibial cartilage and an implanted TEC with the material properties of either native tissue or a decreased elastic modulus and fixed charged density. Creep loading was applied with a rigid impermeable indenter that represented the femur. In comparison with an intact joint, compressive strains in the transplant, surface contact stress in the adjacent native AC and load partitioning between different phases of cartilage were affected by inferior properties of TEC. Results of this study may lead to a better understanding of the complex mechanical environment of an implanted TEC. 相似文献