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1.
BackgroundBreast cancer is the most common malignancy in women world-wide and the most common cause of cancer deaths, which can often be managed with early diagnosis and subsequent treatment. Here, we focus on geographic disparities in incidence within Portugal for three age groups of women (30−49; 50−69; 70−84 years).MethodsAge-period-cohort (APC) models are widely used in cancer surveillance, and these models have recently been extended to allow spatially-varying effects. We apply novel spatial APC models to estimate relative risk and age-adjusted temporal trends at the district level for the 20 districts in Portugal. Our model allows us to report on country-wide trends, but also to investigate geographic disparities between districts and trends within districts.ResultsAge-adjusted breast cancer incidence was increasing over 1998–2011 for all three age groups and in every district in Portugal. However, we detect spatially-structured between-district heterogeneity in relative risk and age-adjusted trends (Net Drifts) for each of the three age groups, which is most pronounced in the highly-screened (50−69yo) and late-onset (70−84yo) groups of women.ConclusionsWe present evidence of disparities in breast cancer incidence at a more granular geographic level than previously reported. Some disparities may be due to latent risk factors, which cannot be accounted for by age, birth year, and geographic location alone.ImpactOur study motivates resuming data collection for breast cancer incidence at the district level in Portugal, as well as the study of exogenous risk factors. 相似文献
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空间属性是动物行为的重要特征,也是行为生态学研究中必须要面对的难题之一。地理信息系统(Geographic Information System,GIS)具有强大的空间分析功能,它在动物行为生态学研究中得到了越来越广泛的应用,如生境选择、领域分析、迁徙路线、活动节律等。本文较系统地阐述了GIS的原理以及在行为生态学研究中所涉及的基本概念和原理,对近年来利用GIS进行的行为生态学研究做了回顾和总结,并对其未来的发展进行了展望。 相似文献
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Ellsworth RE Zhu K Bronfman L Gutchell V Hooke JA Shriver CD 《Cell and tissue banking》2008,9(2):109-120
Age at diagnosis, pathological characteristics, and tumor behavior differ between African American (AAW) and Caucasian women
(CW) with breast cancer, with AAW having more aggressive tumors and higher mortality rates. Although both societal and molecular
contributions to these disparities have been suggested, the African American population has traditionally been under-represented
in research and clinical protocols, limiting the power of epidemiologic and molecular studies to provide better understanding
of disease pathogenesis in this minority population. The Clinical Breast Care Project (CBCP) has developed a large tissue
and blood repository from patients undergoing treatment for breast cancer, with previous history of breast cancer, counseled
in the Risk Reduction Clinic, screened by routine mammography, or undergoing elective reductive mammoplasty. Recruitment of
AAW into the CBCP was successful; 25% of the 2,454 female patients were African American, including 35% disease-free, 3% high-risk,
40% benign, 8% preinvasive and 14% with invasive breast disease. More than 500 data fields regarding lifestyle choices, socioeconomic
status, health history and geography were collected from all participants, and all consenting individuals provided blood specimens
for genomic and proteomic studies. Tissues were collected from all patients undergoing surgical procedures using protocols
that preserve the macromolecules for downstream research applications. In addition, patients were followed after diagnosis,
with >85% of patients providing ongoing and updated demographic and clinical information. Thus, recruitment efforts in the
CBCP have resulted in collection of well-annotated information and research-quality specimens from a large number of AAW.
This unique resource will allow for the identification of biological and environmental factors associated with the identification
of genetic and non-genetic factors associated with the occurrence, detection, prognosis, or survival of breast cancer in AAW.
The opinion and assertions contained herein are the private views of the authors and are not to be construed as official or
as representing the views of the Department of the Army or the Department of Defense. 相似文献
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Shivanand Balram Suzana Dragićević Thomas Meredith 《Biodiversity and Conservation》2004,13(6):1195-1208
Methods for establishing biodiversity conservation priorities are urgently required, as the number of species and habitats that are threatened increases relative to the material resources available for their conservation. The identification of priority areas demands the integration of biophysical data on ecosystems together with social data on human pressures and planning opportunities. But comprehensive and reliable data are rarely available to demarcate where the need for action is most urgent and where the benefits of conservation strategies can be maximized. Strategic conservation initiatives cannot wait for the creation of comprehensive databases. In order to fill the missing data gaps, the combined knowledge of local and technical experts can be used. This study presents a collaborative geographic information system (GIS) method for integrating the knowledge of local and technical experts with existing spatial environmental data to establish priority areas for biodiversity conservation. Procedures for structuring and framing the discussions, establishing assessment criteria, integrating knowledge with data, and building consensus are incorporated into the method. The method provides a novel cooperative mechanism to aid spatial knowledge management and inclusive biodiversity planning. 相似文献
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Eric D. Taber Michael L. Hutchinson Erica A.H. Smithwick Justine I. Blanford 《Journal of vector ecology》2017,42(1):3-12
In recent decades, the Asian tiger mosquito expanded its geographic range throughout the northeastern United States, including Pennsylvania. The establishment of Aedes albopictus in novel areas raises significant public health concerns, since this species is a highly competent vector of several arboviruses, including chikungunya, West Nile, and dengue. In this study, we used geographic information systems (GIS) to examine a decade of colonization by Ae. albopictus throughout Pennsylvania between 2001 and 2010. We examined the spatial and temporal distribution of Ae. albopictus using spatial statistical analysis and examined the risk of dengue virus transmission using a model that captures the probability of transmission. Our findings show that since 2001, the Ae. albopictus population in Pennsylvania has increased, becoming established and expanding in range throughout much of the state. Since 2010, imported cases of dengue fever have been recorded in Pennsylvania. Imported cases of dengue, in combination with summer temperatures conducive for virus transmission, raise the risk of local disease transmission. 相似文献
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We present an initial attempt for the development of a distributed and scalable GIS-like tool for the storage, selection and visualization of 4D marine datasets. The aim of this tool is to standardize the variety of data available for the water column and support non-technical marine biologists in manipulating 4D marine datasets. The tool is developed towards answering specific environmental and biological questions regarding ocean processes and essential fish habitat mapping in three dimensions. Guest editor: V. D. Valavanis Essential Fish Habitat Mapping in the Mediterranean 相似文献
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Nihei N Kajihara N Kirinoki M Chigusa Y Saitoh Y Shimamura R Kaneta H Matsuda H 《Parasitology international》2003,52(4):395-401
There are still many Oncomelania snails that inhabit the Kofu Basin, Yamanashi Prefecture, Japan, which had been declared free of schistosomiasis japonica. Due to the need to monitor the situation, a fixed-point observation system using GIS from GPS is being examined. In addition, in broad present or former endemic areas, survey areas are being managed by remote sensing with satellite images or aerial photographs. A simple and effective monitoring method by mobile GIS using PDAs was developed, risk or hazard maps were prepared and a system that would enable a response in the event of reemergence is being examined. 相似文献
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BackgroundGastrointestinal (GI) cancers represent a diverse group of diseases. We assessed differences in geographic and racial disparities in cancer-specific mortality across subtypes, overall and by patient characteristics, in a geographically and racially diverse US population.MethodsClinical, sociodemographic, and treatment characteristics for patients diagnosed during 2009–2014 with colorectal cancer (CRC), pancreatic cancer, hepatocellular carcinoma (HCC), or gastric cancer in Georgia were obtained from the Surveillance, Epidemiology, and End Results Program database. Patients were classified by geography (rural or urban county) and race and followed for cancer-specific death. Multivariable Cox proportional hazards models were used to calculate stratified hazard ratios (HR) and 95% confidence intervals (CIs) for associations between geography or race and cancer-specific mortality.ResultsOverall, 77% of the study population resided in urban counties and 33% were non-Hispanic Black (NHB). For all subtypes, NHB patients were more likely to reside in urban counties than non-Hispanic White patients. Residing in a rural county was associated with an overall increased hazard of cancer-specific mortality for HCC (HR = 1.15, 95% CI = 1.02–1.31), pancreatic (HR = 1.11, 95% CI = 1.03–1.19), and gastric cancer (HR = 1.17, 95% CI = 1.03–1.32) but near-null for CRC. Overall racial disparities were observed for CRC (HR = 1.18, 95% CI = 1.11–1.25) and HCC (HR = 1.12, 95% CI = 1.01–1.24). Geographic disparities were most pronounced among HCC patients receiving surgery. Racial disparities were pronounced among CRC patients receiving any treatment.ConclusionGeographic disparities were observed for the rarer GI cancer subtypes, and racial disparities were pronounced for CRC. Treatment factors appear to largely drive both disparities. 相似文献
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《Microbes and infection / Institut Pasteur》2014,16(11):902-910
Leptospirosis is a zoonotic infection that is caused by the pathogenic species of Leptospira. Rats are the most important reservoirs of these organisms. Our study aimed to characterize Leptospira isolates from humans and rats and elucidate the Leptospira-rat-human relationship in Luzon, Philippines. Forty strains were isolated from humans and rats. The isolates were confirmed to be Leptospira and pathogenic through rrl- and flaB-PCR, respectively. Around 73% of the isolates were found to be lethal to hamsters. Serotyping showed that there were mainly three predominant leptospiral serogroups in the study areas namely Pyrogenes, Bataviae, and Grippotyphosa. Gyrase B gene sequence analysis showed that all the isolates belonged to Leptospira interrogans. Most had 100% similarity with serovar Manilae (15/40), serovar Losbanos (8/40), and serogroup Grippotyphosa (8/40). Strains from each group had highly identical pulsed-field gel electrophoresis patterns and were further grouped as A (Pyrogenes, 14), B (Bataviae, 8), and C (Grippotyphosa, 10). Results further revealed that similar serotypes were isolated from both humans and rats in the same areas. It is suggested that these three predominant groups with highly similar intra-group PFGE patterns may have been primarily transmitted by rats and persistently caused leptospirosis in humans particularly in the Luzon islands. 相似文献
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目的:分析乳腺癌X线检查的误诊及漏诊情况。方法:选择2013年5月至2015年5月在我院的经乳腺X线和病理检查证实的乳腺肿瘤患者135例为研究对象,比较X线检查结果与病理诊断结果的误诊率及漏诊率,并分析导致误诊及漏诊的因素。结果:135例患者中,术后病理证实为恶性肿瘤63例(46.67%),良性肿瘤72例(53.33%)。63例乳腺恶性肿瘤中,X线误诊为良性5例,误诊率为7.93%。其中1例误诊为乳腺增生,2例误诊为乳腺炎症,1例误诊为术后疤痕挛缩,1例误诊为纤维腺瘤;X线表现为肿块形态呈圆形或类圆形边缘光滑2例,肿块周围出现透亮区1例,乳腺结构扭曲1例。72例良性肿瘤中,X线误诊为恶性7例,误诊率为9.72%。其中4例为乳腺增生,2例为乳腺炎,1例为乳腺纤维瘤,1例为乳腺筋膜炎;X线表现为密度较高而边缘不清的肿块影1例,边缘似有毛刺征1例,伴有钙化、模糊无定型呈散在分布1例,部分边缘有突起或后缘凹凸不平1例,片状影2例(1例密度较高,1例密度较均匀);肿块伴乳晕增厚、乳头内陷1例。结论:乳腺X线检查的准确性受直接征象和间接征象的影响。因此,临床实践中可联合运用乳腺X线检查和乳腺超声或MRI检查,从而提高乳腺肿块诊断的准确率。 相似文献
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Several conservation efforts are being made to recover European rabbit populations (Oryctolagus cuniculus) on the Iberian Peninsula. Some of them focus on burrow management; others involve building different types of warren. A few studies have examined site selection for warren building, and these studies have considered only warren placement within sites and not the broader area surrounding these locations. The objective of this study was to evaluate how landscape pattern determines habitat selection by rabbits for warren building at different spatial scales. Landscape, home range scale, and microhabitat were the spatial scales used in this study. Warrens were not uniformly distributed over the study area but, rather were concentrated in areas with a high abundance and cover of Retama monosperma and high vegetation cover. Rabbits preferred digging warrens in areas with low fragmentation and where patches are few, large, and contiguous. Based on our results, we suggest that a study of landscape structure should be carried out before design habitat management, recovery or translocation programs. Such studies will need to take into account the physiognomy and size, shape, and continuity of patches in fragmented landscapes. Rabbit conservation programs must address areas that provide not only the maximum potential rate of intake, but also good soil and vegetation cover conditions for warren building and suitable surrounding areas. 相似文献
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Rhinopithecus roxellana’s habitat condition is directly related to its long-term survival and reproduction. Research, with large-scale, on R. roxellana’s habitat selection of seasonal changes is conducive to the protection and construction of its habitat, and it is essential protecting the rare species. Our research is based on the results of previous studies in biological and behavioral ecological field. With the support of GIS and RS technology, we conducted a lot of field investigations. In addition, we also took R. roxellana’s selection bias of seven kinds of ecological factors into consideration. Through the above efforts, we got a selection intensity distribution layer about R. roxellana’s habitat selection of seasonal changes. Our study shows that in spring, the area of weak intensity is 1507.96 hm2 while less weak area is 33868.72 hm2. The strong intensity area is 266 hm2 while the less strong area is 36818.84 hm2.
In summer, the area of weak intensity is 4683.4 hm2 while less weak area is 28392.4 hm2. The strong intensity area is 4078.52 hm2 while the less strong area is 35307.2 hm2.
In autumn, the area of weak intensity is 1972.08 hm2 while less weak area is 33254.72 hm2. The strong intensity area is 1516.84 hm2 while the less strong area is 35717.88 hm2.
In winter, the area of weak intensity is 542.76 hm2 while less weak area is 28230.84 hm2. The strong intensity area is 392.44 hm2 while the less strong area is 43295.48 hm2.
The results show that the most forestry areas of the Shennongjia Mt. lie in strong intensity area and these areas provides optimal habitat for the Snub-nosed Monkey.
The distribution layer analyses show that eastern part of the Shennongjia area is coincidence with the current natural distribution of the Snub-nosed Monkey, whereas north-western, south-western and southern part of the area is located in the weak intensity areas and is unfit for the Snub-nosed Monkey. In the central part, the strong intensity areas are fragmented by the highways and no Snub-nosed Monkey is found in this highly disturbed area. However, it is probably a potential habitat for the Snub-nosed Monkey.
Survival and reproduction of the Snub-nosed Monkey was ensured by large and continuous habitat in the eastern part of the Shennongjia Mt. Much effort is needed to intensify the connection of the fragmented central area of the Shennongjia Mt. 相似文献
In summer, the area of weak intensity is 4683.4 hm2 while less weak area is 28392.4 hm2. The strong intensity area is 4078.52 hm2 while the less strong area is 35307.2 hm2.
In autumn, the area of weak intensity is 1972.08 hm2 while less weak area is 33254.72 hm2. The strong intensity area is 1516.84 hm2 while the less strong area is 35717.88 hm2.
In winter, the area of weak intensity is 542.76 hm2 while less weak area is 28230.84 hm2. The strong intensity area is 392.44 hm2 while the less strong area is 43295.48 hm2.
The results show that the most forestry areas of the Shennongjia Mt. lie in strong intensity area and these areas provides optimal habitat for the Snub-nosed Monkey.
The distribution layer analyses show that eastern part of the Shennongjia area is coincidence with the current natural distribution of the Snub-nosed Monkey, whereas north-western, south-western and southern part of the area is located in the weak intensity areas and is unfit for the Snub-nosed Monkey. In the central part, the strong intensity areas are fragmented by the highways and no Snub-nosed Monkey is found in this highly disturbed area. However, it is probably a potential habitat for the Snub-nosed Monkey.
Survival and reproduction of the Snub-nosed Monkey was ensured by large and continuous habitat in the eastern part of the Shennongjia Mt. Much effort is needed to intensify the connection of the fragmented central area of the Shennongjia Mt. 相似文献
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Lora E. Fleming Carlos Rivero John Burns Chris Williams Judy A. Bean Kathleen A. Shea John Stinn 《Harmful algae》2002,1(2):157-168
The blue green algae or cyanobacteria represent a diverse group of organisms that produce potent natural toxins. There have been case reports of severe morbidity and mortality in domestic animals through drinking water contaminated by these toxins. Microcystins, in particular, have been associated with acute liver damage and possibly liver cancer in laboratory animals. Although, there has been little epidemiologic research on toxin effects in humans, a study by Yu (1995) found an association between primary liver cancer and surface water. Surface water drinking supplies are particularly vulnerable to the growth of these organisms; current US drinking water treatment practices do not monitor or actively treat for blue green algal toxins including the microcystins.After a monitoring survey in Florida found organisms and microcystins (among other cyanobacterial toxins) in surface water drinking sources, a pilot ecological study was performed using a Geographic Information System (GIS) to evaluate the risk of primary hepatocellular carcinoma (HCC) and proximity to a surface water treatment plant at cancer diagnosis. The study linked all HCC cancers diagnosed in Florida from 1981 to 1998 with environmental databases.A significantly increased risk for HCC with residence within the service area of a surface water treatment plant was found compared to persons living in areas contiguous to the surface water treatment plants. However, this increased risk was not seen in comparison to persons living in randomly selected ground water treatment service areas or compared to the Florida cumulative incidence rate for the study period, using various comparison and GIS methodologies. Furthermore, these findings must be interpreted in light of significant issues of latency, high population mobility, and the lack of individual exposure information. Nevertheless, the issue of acute and chronic human health effects associated with the consumption of surface waters possibly contaminated by blue green algal toxins merits further investigation. 相似文献
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BackgroundThe incidence of colorectal cancer (CRC) in young adults is increasing. Minority populations with CRC are known to have worse survival outcomes. The aim of this study is to evaluate adults under age 50 years with CRC by race and ethnicity.MethodsData were obtained from all US hospitals that contributed to the National Cancer Database (NCDB) between 2004 and 2013. Univariate and multivariable testing was done to identify factors associated with patient outcome. Kaplan-Meier analysis and Cox proportional hazards models were used for association between patient characteristics and survival.ResultsA total of 83,449 patients between 18 and 50 years of age were identified. Median age was 45 years (SD ± 6), with male preponderance (53.9%). 72% were non-Hispanic Whites (NHW), Blacks (AA) were 15.1% and Hispanics (who did not identify as Blacks) were 8.3% of the study population. Distribution across stages IIV was 15.6%, 22.4%, 33.9% and 27% consecutively. 41.8% of NHW and 28.4% of AA had rectal cancers (p < 0.001). Despite equally receiving standard of care (SOC) as per national guidelines, AA had significantly lower 5-year survival rates (58.8%) compared to Hispanics (64.8%) and NHW (66.9%; HR 1.42; 1.38-1.46; p < 0.001). Furthermore, NHW (HR 0.85; 0.81-0.88; p < 0.001) and Hispanics (HR 0.75; 0.70-0.79; p < 0.001) were more likely to benefit from chemotherapy compared to AA. SOC utilization was associated with improved survival across all racial groups, especially in AA (HR 0.64; 0.60-0.69; p < 0.001).ConclusionDespite comparable rates of SOC utilization, AA young adults had worse survival outcomes compared to other races. More colon (compared to rectal) cancers in AA may have contributed to their worse outcomes. 相似文献
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江苏盐城自然保护区獐栖息地的质量评价 总被引:3,自引:1,他引:2
本研究通过1999 年3 月至2000 年11 月期间的实地调查,利用地理信息系统(GIS)对江苏省盐城自然保护区及周边地区獐在产仔前期、产仔期以及产仔后期栖息地适宜性进行了评价,并对理想状况下獐的潜在栖息地和实际栖息地的范围及分布进行了比较。理想状况下3 个不同时期獐的最适宜栖息地面积分别为361.0 km2 、267. 5 km2 和338. 5 km2, 主要分布在保护区核心区、东台市琼港镇南的新东乡滩涂;而实际在各个时期獐的最适宜栖息地面积只有44.75 km2 、36.00 km2 和54. 50 km2 ,仅为潜在栖息地的1/7 左右。通过比较獐的潜在栖息地与实际栖息地的综合适宜性指数发现,整个研究地区适合獐生存的栖息地非常少,最适宜栖息地的面积不到总面积的1%,而不适宜的栖息地面积却达到40%,其余大部分均是次适宜的栖息地。由于獐的栖息地受到道路和居民等人为活动的影响,导致大量适宜栖息地丧失。为了有效地保护盐城保护区及周边地区的獐种群,建议减少对滩涂的各种开发活动,保护现有的适宜栖息地,引导当地居民合理利用滩涂资源。 相似文献
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借助地理信息系统软件的表格操作及邻体分析功能,以海南霸王岭自然保护区的沟谷雨林为例,探讨热带雨林的取样技术。结果表明,用种.面积曲线所获得的热带雨林的最小面积往往过大,而采用重要值.面积曲线所确定的最小面积则为4000m^2;无样地取样采用最近个体法,由种.点数曲线可以确定最少点数为119,而采用重要值.点数曲线,可以确定该雨林取样的最小点数为280。种.个体曲线表明,如果要获取多一倍的物种数,则所需调查的个体数应是原来的4倍。 相似文献
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由中国生态学会、中国生态经济学会、中国城市科学研究会联合召开的“全国城市生态科学讨论会”于1984年12月2—6日在上海复旦大学举行。到会的有来自19个省、自治区和市的从事生态、环保、地理、社会、经济和城市规划等24个专业的代表共80人,共收到学术论文43篇。中国生态学会理事长马世骏同志,中国生态经济学会副理事长兼秘书长王耕今同志,中国城市科学研究会秘书长李梦白同志主持了会议。首届全国城市生态科学讨论会的中心议题是:探讨城市生态学研究的目的、任务、对象和方法等基本理论问题,用城市生态学的观点分析我国不同类型城市在规划建设和管理中存在的重大问题;并就解决这些问题提出可行建议。 相似文献