共查询到20条相似文献,搜索用时 31 毫秒
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Anjum Zafar Fan Wu Kristine Hardy Jasmine Li Wen Juan Tu Robert McCuaig Janelle Harris Kum Kum Khanna Joanne Attema Philip A. Gregory Gregory J. Goodall Kirsti Harrington Jane E. Dahlstrom Tara Boulding Rebecca Madden Abel Tan Peter J. Milburn Sudha Rao 《Molecular and cellular biology》2014,34(16):2961-2980
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Epithelial–mesenchymal transition (EMT) is a crucial step in tumor progression and has an important role during cancer invasion and metastasis. Although fucosyltransferase IV (FUT4) has been implicated in the modulation of cell migration, invasion and cancer metastasis, its role during EMT is unclear. This study explores the molecular mechanisms of the involvement of FUT4 in EMT in breast cancer cells. Breast cancer cell lines display increased expression of FUT4, which is accompanied by enhanced appearance of the mesenchymal phenotype and which can be reversed by knockdown of endogenous FUT4. Moreover, FUT4 induced activation of phosphatidylinositol 3-kinase (PI3K)/Akt, and inactivation of GSK3β and nuclear translocation of NF-κB, resulting in increased Snail and MMP-9 expression and greater cell motility. Taken together, these findings indicate that FUT4 has a role in EMT through activation of the PI3K/Akt and NF-κB signaling systems, which induce the key mediators Snail and MMP-9 and facilitate the acquisition of a mesenchymal phenotype. Our findings support the possibility that FUT4 is a novel regulator of EMT in breast cancer cells and a promising target for cancer therapy. 相似文献
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Xin Zheng Natalia B. Rumie Vittar Xiaohong Gai Maite G. Fernandez-Barrena Catherine D. Moser Chunling Hu Luciana L. Almada Angela L. McCleary-Wheeler Sherine F. Elsawa Anne M. Vrabel Abdirashid M. Shire Andrea Comba Snorri S. Thorgeirsson Youngsoo Kim Qingguang Liu Martin E. Fernandez-Zapico Lewis R. Roberts 《PloS one》2012,7(11)
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上皮间质转化(epithelial-mesenchymal transition,EMT)是指上皮细胞失去连接和极性转变为间质细胞的过程,这一现象普遍存在于胚胎发育、创伤愈合、器官纤维化以及肿瘤转移.在胚胎早期发育和晚期发育过程,例如着床、原肠运动、心血管发育等事件中有EMT和间质上皮转化(mesenchymal-ep... 相似文献