Modeling of human CCR5 as Target for HIV-I and Virtual Screening with Marine Therapeutic compounds

Marine derivatives are of great pharmaceutical interest as inhibitory compound and search of bioactive compounds from Marine organism which is relatively new to medicinal chemistry. Our main aim in the study is to screen possible inhibitors against CCR5 which acts as co-receptor M-tropic HIV-1, through virtual screening of 122 Marine derived compounds from various organisms known to have biological activity. Homology Model of CCR5 was constructed using MODELLER and the Model was energy minimized and validated using PROCHECK to obtain a stable structure, which was further used for virtual screening of Marine derived compounds through molecular Docking studies using GOLD. The Docked complexes were validated and Enumerated based on the GOLD Scoring function to pick out the best Marine inhibitor based on GOLD score. Thus from the entire 122 Marine compounds which were Docked, we got best 4 of them with optimal GOLD Score. (LAMIVUDINE: 45.0218, BATZELLINE-D: 44.3852.ACYCLOVIR: 43.1362 and THIIOACETAMIDE: 42.7412) Further the Complexes were analyzed through LIGPLOT for their interaction for the 4 best docked Marine compounds. Thus from the Complex scoring and binding ability its deciphered that these Marine compounds could be promising inhibitors for M-tropic HIV-1 using CCR5 as Drug target yet pharmacological studies have to confirm it.     

海洋生物多样性损害与沿海地区经济增长关系实证研究

海洋生物多样性是海洋生态系统服务的基础,保护海洋生物多样性不仅对维持地球生态系统的功能至关重要,也与人类福祉密切相关。基于沿海11个省区生态系统亚健康程度指标和物种多样性损害指标,运用面板回归模型对中国沿海地区经济增长与海洋生物多样性损害的关系进行实证考察。研究结果表明：(1)海洋生态系统亚健康程度与沿海地区经济增长之间存在显著的线性关系,随着经济增长,典型海洋生态系统亚健康状态占比呈现出持续上升趋势。此外,实施排污费制度和建立海洋自然保护区有利于抑制海洋生态系统的恶化。(2)海洋物种多样性损害与沿海地区经济增长之间存在显著“倒U”型关系,随着经济增长,海洋物种多样性损害呈现先上升后下降的态势,转折点为人均GDP 45145元,目前海南省、广西壮族自治区、河北省未跨过转折点。此外,排污费制度有利于抑制海洋物种多样性损害,而沿海地区目前的产业结构加重了海洋物种多样性损害。根据实证分析结果,海洋生态系统健康尚未出现拐点,沿海地区经济增长如果建立在对生态环境破坏的基础上,则势必会造成生物多样性的损害。因此从规范海域利用方式,完善海岸生态保护红线划定,加强生态系统的监测与管理,保持绿色可持续的...     

Waste biotech

US market for environmental biotech products for waste treatment worth $261.3 M by 2013 Marine pharmacognosy Recent patents related to biowaste and bioactive compounds Project profile: Concentration and separation of bioactives in food science Microbial-based motor fuels Dairy fermentation, cell factories and bioactive peptides Earliest genetic material: Waste from the stars? Marine bacteria use carbon dioxide     

“海洋微生物学实验”课程思政探索和实践

"海洋微生物学实验"课程是高等院校海洋科学类专业的重要基础课程,在海洋科学人才培养过程中发挥重要作用。开展"海洋微生物学实验"课程的思政建设,是落实高校全员全程全方位培养青年海洋微生物人才的重要途径。本文以"海洋微生物学实验"课程为例,挖掘提炼课程中蕴含的思政元素,从课程建设、教学理念、教学目标、教学方法、考核评价体系、教学反思等方面开展课程思政教育的探索和实践,旨在将专业知识和思政元素有机融合,实现知识传授和价值引领同频共振。     

海洋生境制图研究进展: 概念、方法与应用

基于生态系统的海洋管理采用生态边界而非行政边界来指导管理实践, 海洋生境制图旨在探寻海洋环境与生物群落/物种的分布规律, 从而为生物多样性保护和海洋空间规划等管理行动提供可以依循的生态边界。海洋生境制图是科研监测数据通往管理决策应用的有效途径, 近年来已成为海洋生态保护与管理领域的国际研究热点, 但我国对于海洋生境制图的研究才刚刚起步。本文对海洋生境制图的国内外研究进展进行了综述, 介绍了海洋生境制图的定义和内涵, 明确了海洋生境制图的步骤及其在生态系统管理中的应用; 系统阐述了海洋生境制图的主要研究方法, 从生境分类方案、生境分区和生态特征描述等方面对海洋生境制图的研究过程及采用的分析方法进行了总结; 全面梳理了国内外的代表性海洋生境制图研究案例, 对各国已开发的海洋生境分类分区体系进行了对比和评述, 总结了共性特征; 最后提出研究建议, 对我国开展海洋生境制图研究的前景进行展望, 以期为我国的海洋生态空间管理工作提供科学依据和参考。     

Resources available to individuals and organisations involved with marine turtle research and conservation in the Mediterranean

Abstract

We review some key resources freely or cheaply available to those involved with marine turtle research and conservation in the Mediterranean. These include: Marine Turtle Newsletter, Listservs, bibliographic databases, Mediterranean specific technical manuals, IUCN Marine Turtle Specialist Group publications, internet sources and books.     

BOOK REVIEWS

Book reviewed in this article:
H oelzel , A. R. (Ed.) 2002. Marine mammal biology: an evolutionary approach .     

The Sperm Ultrastructure and Some Reproductive Characteristics of the Chemosymbiotic Bivalve Calyptogena pacifica Dall, 1891 (Vesicomyidae: Pliocardiinae)

Russian Journal of Marine Biology - Pliocardiines (Bivalvia: Vesicomyidae: Pliocardiinae) are a chemosymbiotrophic group of bivalve mollusks that are obligate for reducing environments. These...     

Archaeology

The Underwater Dig: An Introduction to Marine Archeology. Robert Marx .
Deep Water, Ancient Ships: The Treasure Vault of the Mediterranean. Willard Bascom .     

A field test of porous carbonated blocks used as artificial reef in seaweed beds of <Emphasis Type="Italic">Ecklonia cava</Emphasis>

Marine forests are the main primary producer in coastal waters, supplying food to fish and shellfish as well as providing their spawning and growing sites. It is important to conserve marine forest in order to protect coastal marine environments. A “Marine Block” comprised of steelmaking slag particles combined by CaCO₃ has several merits: (1) solidification of CO₂, (2) stability and safety, (3) porous materials covered with CaCO₃, (4) harmony with the seabed environment, (5) recycling of iron by-products, and (6) the ability to be mass produced in coastal ironworks. The objectives of this study were to observe the algal succession, the growth of Ecklonia cava and other attached organisms on Marine Blocks and concrete blocks compared to natural seaweed beds. In November 2001, five 1 m³ Marine Blocks and five 1 m³ concrete blocks were installed close to E. cava beds around the coastal frontage of Jogashima at the mouth of Tokyo Bay. Scuba-diving observations were continued until April 2006. In the field, a large number of seaweed and animal species were observed on the Marine Blocks, and it was found that the speed of succession, the plant length and the wet weight of E. cava were greater on Marine Blocks than on concrete blocks. The main advantages of Marine Blocks are considered to be the recycling of steelmaking slag, the absorption and solidification of atmospheric CO₂, and the conservation of coastal environments.     

Gelatinous and soft-bodied zooplankton in the Northeast Pacific Ocean: Phosphorus content and potential resilience to phosphorus limitation

Hydrobiologia - Marine ecosystems on continental shelves face multiple challenges due to anthropogenic disturbances, many of which can change the seawater stoichiometry (C:N:P) and consequently...     

Structural diversity and geographical distribution of halogenated secondary metabolites in red algae,Laurencia nangii Masuda (Rhodomelaceae,Ceramiales), in the coastal waters of North Borneo Island

The red algae genus Laurencia (Rhodomelaceae, Ceramiales) is known as a prolific producer of halogenated secondary metabolites with a high level of species diversity and geographical distribution. In North Borneo Island, Malaysia, there are four main Laurencia species: Laurencia snackeyi, Laurencia majuscula, Laurencia similis and L. nangii. Although the chemistry of Laurencia is well studied, the diversity of compounds in L. nangii has not been thoroughly investigated. Therefore, we studied the chemical constituents of seven populations of L. nangii from Tunku Abdul Rahman Marine Park (two populations), Dinawan Island (one population), Tun Mustapha Marine Park (two populations) and Tun Sakaran Marine Park (two populations). Halogenated compounds were isolated and the structures determined via spectroscopic methods. A total of 20 metabolites belonging to the classes of sesquiterpenes, acetylenes, bromoallenes, diterpenes and triterpenes were identified. Populations from Tunku Abdul Rahman Marine Park and Dinawan Island contained non-chamigrane-type sesquiterpenes, acetylenes and diterpenes. Populations from Tun Mustapha Marine Park contained chamigrane-type sesquiterpenes, acetylenes and diterpenes. However, the chemical compositions of populations from Tun Sakaran Marine Park were found to differ significantly, containing chamigrane-type and non-chamigrane-type sesquiterpenes, bromoallenes and triterpenes. This investigation has revealed the presence of interesting chemotaxonomical markers in populations of L. nangii and the existence of chemical races in this species.     

Homo Sapiens 1900

Trauma und Ressourcen/Trauma and Empowerment. Marine Verwey. ed. Berlin: Society of Ethnomedicine, Curare/Sonderband, 2001.358pp.     

Book Reviews

Book reviewed in this article:
Global Warming: Implications for Fresh Water and Marine Fish, by CM. Wood and D.G. MacDonald.
Ecology in Agriculture, edited by Louise E. Jackson.     

Marine bioactivity in Irish waters

In 2009, the Marine Biodiscovery Laboratory was set-up at the Marine Institute with funds from the Marine Institute and the Beaufort Marine Biodiscovery Research Programme. The Marine Biodiscovery Laboratory has already processed over 130 marine specimens from coastal zones and from the Deep Sea (≤3,000 m) within the Marine Irish Exclusive Economic Zone. Beaufort Biodiscovery funded taxonomists are involved in species identification and elucidation of evolutionary relationships. The project approach links sampling, systematics, extraction, microbial metagenomics and biomaterials. The Laboratory consists of approximately 56 m² including an extraction and a bioassay suite. The Laboratory samples and assesses marine biological diversity geared towards developing natural products for drug discovery, advanced material applications and bio-medical devices. Samples are tracked from sample log-into right through to extraction and bioassay using a customised Marine Biodiscovery Database. The extraction procedure is described along with the anti-bacterial bioassay selected for routine use. The Marine Biodiscovery Database manages the data generated and links the data collected by the project’s stakeholders to existing biodiversity, genetic and chemical resources. The system uses in-house developed software tools to merge biodiscovery data collected with other MI resources and external databases and for the data mining and visualisation of biogeographical, genetic and chemical information aimed at the identification of potential biodiversity and bioactivity “hotspots”.     

CRISPR/Cas9-Mediated Transgenesis of the Masu Salmon (Oncorhynchus masou) elovl2 Gene Improves n-3 Fatty Acid Content in Channel Catfish (Ictalurus punctatus)

Marine Biotechnology - Omega-3 polyunsaturated fatty acids (n-3 PUFAs), particularly eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3), play a very important role in...     

Book Review

Book reviewed in this article:
Marine Mammals of the World. CD-ROM Version 1.0 —T. A. Jefferson, S. Leatherwood and M. A. Webber.     

Larval Settlement and the Reproductive Phenology of Sympathric Hermit Crabs in Temperate Waters

Russian Journal of Marine Biology - The problem of the coexistence of closely related species of Paguroidea (Decapoda: Anomura) and the main mechanisms of structuring the communities of these...     

The First Record of the Brown Endophytic Alga Laminariocolax aecidioides (Rosenvinge) A.F. Peters, 1998 in the Russian Far-Eastern Seas

Russian Journal of Marine Biology - The brown endophytic alga Laminariocolax aecidioides (Ectocarpales: Chordariaceae) growing in Undaria pinnatifida was found in Ussuriisky Bay (Peter the Great...     

The Reproductive Strategy of Hermit Crabs in Temperate Waters

Russian Journal of Marine Biology - This review examines the main characteristics of the reproductive strategy in hermit crabs: the sex ratio, the age (size) of onset of maturity, fecundity, and...