共查询到20条相似文献,搜索用时 31 毫秒
1.
Background
Constraint-based models enable structured cellular representations in which intracellular kinetics are circumvented. These models, combined with experimental data, are useful analytical tools to estimate the state exhibited (the phenotype) by the cells at given pseudo-steady conditions. 相似文献2.
Background
Possible methods for distinguishing receptor binding models and analysing their parameters are considered. 相似文献3.
Background
Robustness of mathematical models of biochemical networks is important for validation purposes and can be used as a means of selecting between different competing models. Tools for quantifying parametric robustness are needed. 相似文献4.
Jonathan CM Clark Toru Akiyama Crispin R Dass Peter FM Choong 《Cancer cell international》2010,10(1):20
Background
Chondrosarcoma responds poorly to adjuvant therapy and new, clinically relevant animal models are required to test targeted therapy. 相似文献5.
Background
Accurate protein loop structure models are important to understand functions of many proteins. Identifying the native or near-native models by distinguishing them from the misfolded ones is a critical step in protein loop structure prediction. 相似文献6.
Biotic interactions influence the projected distribution of a specialist mammal under climate change
Brooke L. Bateman Jeremy VanDerWal Stephen E. Williams Christopher N. Johnson 《Diversity & distributions》2012,18(9):861-872
Aim
To measure the effects of including biotic interactions on climate‐based species distribution models (SDMs) used to predict distribution shifts under climate change. We evaluated the performance of distribution models for an endangered marsupial, the northern bettong (Bettongia tropica), comparing models that used only climate variables with models that also took into account biotic interactions.Location
North‐east Queensland, Australia.Methods
We developed separate climate‐based distribution models for the northern bettong, its two main resources and a competitor species. We then constructed models for the northern bettong by including climate suitability estimates for the resources and competitor as additional predictor variables to make climate + resource and climate + resource + competition models. We projected these models onto seven future climate scenarios and compared predictions of northern bettong distribution made by these differently structured models, using a ‘global’ metric, the I similarity statistic, to measure overlap in distribution and a ‘local’ metric to identify where predictions differed significantly.Results
Inclusion of food resource biotic interactions improved model performance. Over moderate climate changes, up to 3.0 °C of warming, the climate‐only model for the northern bettong gave similar predictions of distribution to the more complex models including interactions, with differences only at the margins of predicted distributions. For climate changes beyond 3.0 °C, model predictions diverged significantly. The interactive model predicted less contraction of distribution than the simpler climate‐only model.Main conclusions
Distribution models that account for interactions with other species, in particular direct resources, improve model predictions in the present‐day climate. For larger climate changes, shifts in distribution of interacting species cause predictions of interactive models to diverge from climate‐only models. Incorporating interactions with other species in SDMs may be needed for long‐term prediction of changes in distribution of species under climate change, particularly for specialized species strongly dependent on a small number of biotic interactions. 相似文献7.
Moacir F Oliveira Andrea Mess Carlos E Ambrósio Carlos AG Dantas Phelipe O Favaron Maria A Miglino 《Reproductive biology and endocrinology : RB&E》2008,6(1):39
Background
Placentas of guinea pig-related rodents are appropriate animal models for human placentation because of their striking similarities to those of humans. To optimize the pool of potential models in this context, it is essential to identify the occurrence of characters in close relatives. 相似文献8.
Sean R Eddy 《BMC bioinformatics》2002,3(1):18-16
Background
Covariance models (CMs) are probabilistic models of RNA secondary structure, analogous to profile hidden Markov models of linear sequence. The dynamic programming algorithm for aligning a CM to an RNA sequence of length N is O(N 3) in memory. This is only practical for small RNAs. 相似文献9.
Jens B Andersen Bent B Roldgaard Ariel B Lindner Bjarke B Christensen Tine R Licht 《BMC microbiology》2006,6(1):86-8
Background
Existing virulence models are often difficult to apply for quantitative comparison of invasion potentials of Listeria monocytogenes. Well-to-well variation between cell-line based in vitro assays is practically unavoidable, and variation between individual animals is the cause of large deviations in the observed capacity for infection when animal models are used. 相似文献10.
Alexander C Langheinrich Mesut Yeniguen Anne Ostendorf Simone Marhoffer Marian Kampschulte Georg Bachmann Erwin Stolz Tibo Gerriets 《BMC neurology》2010,10(1):36
Background
Animal models of focal cerebral ischemia are widely used in stroke research. The purpose of our study was to evaluate and compare the cerebral macro- and microvascular architecture of rats in two different models of permanent middle cerebral artery occlusion using an innovative quantitative micro- and nano-CT imaging technique. 相似文献11.
Background
When predictive survival models are built from high-dimensional data, there are often additional covariates, such as clinical scores, that by all means have to be included into the final model. While there are several techniques for the fitting of sparse high-dimensional survival models by penalized parameter estimation, none allows for explicit consideration of such mandatory covariates. 相似文献12.
Background
Surrogate pain models have been extensively tested in Normal Human Volunteers (NHV). There are few studies that examined pain models in chronic pain patients. Patients are likely to have altered pain mechanisms. It is of interest to test patient pain responses to selective pain stimuli under controlled laboratory conditions. 相似文献13.
Background
Secondary structure prediction is a useful first step toward 3D structure prediction. A number of successful secondary structure prediction methods use neural networks, but unfortunately, neural networks are not intuitively interpretable. On the contrary, hidden Markov models are graphical interpretable models. Moreover, they have been successfully used in many bioinformatic applications. Because they offer a strong statistical background and allow model interpretation, we propose a method based on hidden Markov models. 相似文献14.
Background
Profile hidden Markov models (profile-HMMs) are sensitive tools for remote protein homology detection, but the main scoring algorithms, Viterbi or Forward, require considerable time to search large sequence databases. 相似文献15.
Elise Jeannesson Gérard Siest Mohamed Zaiou Hind Berrahmoune Christine Masson Sophie Visvikis-Siest 《Cell biology and toxicology》2009,25(6):561-571
Background
Cell lines are widely used to monitor drug pharmacokinetics and pharmacodynamics and to investigate a number of biochemical mechanisms. However, little is known about the genetic profile of these in vitro models. 相似文献16.
17.
Hans Koch Ralf-Dieter Bousseljot Olaf Kosch Cosima Jahnke Ingo Paetsch Eckart Fleck Bernhard Schnackenburg 《Biomedical engineering online》2011,10(1):11
Background
The evaluation, verification and comparison of different numerical heart models are difficult without a commonly available database that could be utilized as a reference. Our aim was to compile an exemplary dataset. 相似文献18.
Background
Estimators of free energies are routinely used to judge the quality of protein structural models. As these estimators still present inaccuracies, they are frequently evaluated by discriminating native or native-like conformations from large ensembles of so-called decoy structures. 相似文献19.
Background
New approaches are needed for large-scale predictive modeling of cellular signaling networks. While mass action and enzyme kinetic approaches require extensive biochemical data, current logic-based approaches are used primarily for qualitative predictions and have lacked direct quantitative comparison with biochemical models. 相似文献20.
Mark AJ Roberts Elias August Abdullah Hamadeh Philip K Maini Patrick E McSharry Judith P Armitage Antonis Papachristodoulou 《BMC systems biology》2009,3(1):105-14