共查询到20条相似文献,搜索用时 80 毫秒
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Hwang YS Seo JJ Cha SW Lee HS Lee SY Roh DH Kung Hf HF Kim J Ja Park M 《Biochemical and biophysical research communications》2002,292(4):1081-1086
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We have identified a novel homeobox gene, Xvent-1, that is differentially expressed in the ventral marginal zone of the early Xenopus gastrula. Evidence is presented from mRNA microinjection experiments for a role for this gene in dorsoventral patterning of mesoderm. First, Xvent-1 is induced by BMP-4, a gene known to be a key regulator of ventral mesoderm development. Second, Xvent-1 and the organizer-specific gene goosecoid are able to interact, directly or indirectly, in a cross-regulatory loop suppressing each other's expression, consistent with their mutually exclusive expression in the marginal zone. Third, microinjection of Xvent-1 mRNA ventralizes dorsal mesoderm. The results suggest that Xvent-1 functions in a ventral signaling pathway that maintains the ventral mesodermal state and antagonizes the Spemann organizer. 相似文献
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c-Jun (AP-1) activates BMP-4 transcription in Xenopus embryos 总被引:2,自引:0,他引:2
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Dong L Zhang X Fu X Zhang X Gao X Zhu M Wang X Yang Z Jensen ON Saarikettu J Yao Z Silvennoinen O Yang J 《The Journal of biological chemistry》2011,286(5):3451-3459
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