共查询到20条相似文献,搜索用时 31 毫秒
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Marianne Berwick Jamie MacArthur Irene Orlow Peter Kanetsky Colin B. Begg Li Luo Anne Reiner Ajay Sharma Bruce K. Armstrong Anne Kricker Anne E. Cust Loraine D. Marrett Stephen B. Gruber Hoda Anton‐Culver Roberto Zanetti Stefano Rosso Richard P. Gallagher Terence Dwyer Alison Venn Klaus Busam Lynn From Kirsten White Nancy E. Thomas the GEM Study Group 《Pigment cell & melanoma research》2014,27(3):485-488
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FRIEDRICH BEERMANN ERIKA SCHMID RUTH GANSS GÜNTHER SCHÜTZ SIEGFRIED RUPPERT 《Pigment cell & melanoma research》1992,5(5):295-299
Tyrosinase is the key enzyme in melanin synthesis, and is expressed in the pigment epithelium of the retina, a cell layer derived from the optic cup; and in neural crest-derived melanocytes of skin, hair follicle, choroid, and iris. The tyrosinase gene has been cloned and shown to map to the well-characterized c-locus (albino locus) of the mouse. Subsequent studies demonstrated that a functional tyrosinase minigene was able to rescue the albino phenotype in transgenic mice. The transgene was expressed in a cell type-specific manner in skin and eye. During development of the mouse, the tyrosinase gene is expressed in the pigment epithelium of the retina as early as day 10.5 of gestation. In the hair follicle, tyrosinase gene expression is detected from day 16.5 onwards. This cell-type–specific expression is largely reproduced in transgenic mice. Our results suggest that sequences in the immediate vicinity of the mouse tyrosinase gene are sufficient to provide cell type-specificity and developmental regulation in melanocytes and the pigment epithelium. 相似文献
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Regulation of cell proliferation in the retinal pigment epithelium: Differential regulation of the death‐associated protein like‐1 DAPL1 by alternative MITF splice forms
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Xiaoyin Ma Jiajia Hua Guoxiao Zheng Fang Li Chunbao Rao Huirong Li Jing Wang Li Pan Ling Hou 《Pigment cell & melanoma research》2018,31(3):411-422
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Julia C. Cronin John Wunderlich Stacie K. Loftus Todd D. Prickett Xiaomu Wei Katie Ridd Swapna Vemula Allison S. Burrell Neena S. Agrawal Jimmy C. Lin Carolyn E. Banister Phillip Buckhaults Steven A. Rosenberg Boris C. Bastian William J. Pavan Yardena Samuels 《Pigment cell & melanoma research》2009,22(4):435-444
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Nagaharu Tsukiji Ichiro Yajima Kazuhisa Takeda Hiroaki Yamamoto 《Developmental biology》2009,326(2):335-346
Mitf has been reported to play a crucial role in regulating the differentiation of pigment cells in homeothermal animals, i.e. the melanocytes and the retinal pigment epithelium (RPE). However, less is known about the functions of Mitf in the developing RPE. To elucidate such functions, we introduced wild-type and dominant-negative Mitf expression vectors into chick optic vesicles by electroporation. Over-expression of wild-type Mitf altered neural retina cells to become RPE-like and repressed the expression of neural retina markers in vivo. In contrast, dominant-negative Mitf inhibited pigmentation in the RPE. The percentage of BrdU-positive cells decreased during normal RPE development, which was followed by Mitf protein expression. The percentage of BrdU-positive cells decreased in the wild-type Mitf-transfected neural retina, but increased in the dominant-negative Mitf-transfected RPE. p27kip1, one of the cyclin-dependent kinase inhibitors, begins to be expressed in the proximal region of the RPE at stage 16. Transfection of wild-type Mitf induced expression of p27kip1, while transfection of dominant-negative Mitf inhibited p27kip1 expression. We found that Mitf was associated with the endogenous p27kip1 5′ flanking region. These results demonstrate for the first time “in vivo” that Mitf uniquely regulates both differentiation and cell proliferation in the developing RPE. 相似文献
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Tobin DJ 《Pigment cell & melanoma research》2011,24(1):75-88
Although we have made significant progress in understanding the regulation of the UVR‐exposed epidermal‐melanin unit, we know relatively little about how human hair follicle pigmentation is regulated. Progress has been hampered by gaps in our knowledge of the hair growth cycle’s controls, to which hair pigmentation appears tightly coupled. However, pigment cell researchers may have overly focused on the follicular melanocytes of the nocturnal and UVR‐shy mouse as a proxy for human epidermal melanocytes. Here, I emphasize the epidermis‐follicular melanocyte pluralism of human skin, as research models for vitiligo, alopecia areata and melanoma, personal care/cosmetics innovation. Further motivation could be in finding answers to why hair follicle and epidermal pigmentary units remain broadly distinct? Why melanomas tend to originate from epidermal rather than follicular melanocytes? Why multiple follicular melanocyte sub‐populations exist? Why follicular melanocytes are more sensitive to aging influences? In this perspective, I attempt to raise the status of the human hair follicle melanocyte and highlight some species‐specific issues involved which the general reader of the pigmentation literature (with its substantial mouse‐based data) may not fully appreciate. 相似文献
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Woo Jong Choi Misun Kim Ji‐Youn Park Tae Jun Park Hee Young Kang 《Pigment cell & melanoma research》2015,28(1):51-60
Pleiotrophin (PTN) is a secreted heparin‐binding protein that is involved in various biological functions of cell growth and differentiation. Little is known about the effects of PTN on the melanocyte function and skin pigmentation. In this study, we investigated whether PTN would affect melanogenesis. PTN was expressed in melanocytes and fibroblasts of human skin. Transfection studies revealed that PTN decreased melanogenesis, probably through MITF degradation via Erk1/2 activation in melanocytes. The inhibitory action of PTN in pigmentation was further confirmed in ex vivo cultured skin and in the melanocytes cocultured with fibroblasts. These findings suggest that PTN is a crucial factor for the regulation of melanogenesis in the skin. 相似文献