25例异位妊娠临床分析

２５例异位妊娠临床分析邱玉莲广西昭平县人民医院妇产科５４６８００异位妊娠是妇科常见的急腹症之一,近年来国内外报道的异位妊娠发病率有明显增加。本病多数起病急,病情重,若延误诊断及治疗可引起严重后果,甚至死亡。为了提高诊疗水平,现将我院１９９２年１月～１...     

异位妊娠125例临床分析

异位妊娠是妇科常见的急血症之一,若诊断不及时可因腹腔内出血而危及病人的生命,该病国内外报道均呈上升趋势.现将我院1995年5月至1996年4月收治的异位妊娠125例的临床资料进行分析.1 临床资料1.1 发病相关因素 ①发病年龄;本组年龄最小18岁,最大45岁,23岁～35岁106例,18岁～22岁12例,36岁～45岁7例.②婚育史;125例中未婚者23例,经产妇59例,未产妇66例,有人工流产史者93例.③宫内节育器(IUD)的情况;125例病人带宫内节育器26例.④腹部手术史:125例病人中25例有腹部手术史,其中剖宫产12例,既注异位妊娠做过手术的6例,输卵管结扎术后5例,阑尾     

异位妊娠41例的临床观察

目的 探讨降低异位妊娠引起失血性休克的发生率,减少死亡率.方法 41例异位妊娠患者进行密切观察病情变化,并协助医生及早诊断. 结果 41例异位妊娠患者全部治愈出院. 结论 异位妊娠是妇科常见的急腹症之一,发病急、病情重,处理是否正确,直接影响患者的生命安全.     

异位妊娠误诊盆腔炎1例

患者，25岁，孕1产0，因停经70天，反复阴道流血及下腹痛15天，加重5h，于2008年1月29日17时入院。末次月经2007年11月19日，停经后自测尿妊娠试验阳性，停经55天开始出现少许阴道流血，色淡红，伴下腹闷痛，未作任何处理，1天后症状消失。隔4天后再次出现下腹绞痛、腰骶痛，伴阴道流血，量多于月经，色暗红，伴有血块及肉样组织，持续2天阴道流血逐渐减少，5天均未作任何处理，     

异位妊娠的早期诊断和治疗新进展

正异位妊娠是指孕卵着床于子宫以外,主要以输卵管妊娠为主,是妇产科临床常见急腹症,是导致孕产妇死亡的主要原因之一[1]。近年来,我国异位妊娠发病率呈明显上升和低龄化发展趋势,国内文献[2]报道,异位妊娠最小发病年龄为16岁,因此,如何有效挽救患者的生命和保留患者生育功能一直是临床研究的重点。目前,临床上随着高敏感度的放射免疫检测及B超检查技术不断提高,不少异位妊娠在出现典型症状之前就能明确诊断。而治疗上,腹腔镜手术和以米非     

输卵管妊娠患者术后重复性异位妊娠情况及其影响因素分析

目的:总结输卵管妊娠患者术后重复性异位妊娠情况,并分析其影响因素。方法:选取2015年1月至2017年1月于我院行输卵管妊娠手术的86例患者作为研究对象,回顾性分析所有患者的临床及随访资料,记录并总结所有患者年龄、孕次、产次、月经史、不孕史、血人绒毛膜促性腺激素(HCG)水平、妊娠部位、手术情况、避孕方式以及疾病史等和术后重复性异位妊娠发生情况,并比较不同特征患者术后重复性异位妊娠的发生率,分析影响输卵管妊娠患者术后重复性异位妊娠情况的影响因素。结果:至随访结束,86例输卵管妊娠手术患者术后出现重复性异位妊娠者22例,发生率为25.58%;年龄越大、孕、产次越多、HCG水平越高、存在不孕史、异位妊娠史、输卵管手术史、盆腔感染史以及开腹手术、双侧输卵管粘连及闭锁和长期放置宫内节育器进行避孕的患者其输卵管妊娠术后重复性异位妊娠发生率均明显较高(P0.05);经多因素Logistic回归模型分析可得存在不孕史、盆腔感染史、异位妊娠史、输卵管手术史、输卵管双侧粘连及闭锁以及开腹手术是输卵管妊娠手术患者术后重复性异位妊娠发生的独立危险因素(P0.05)。结论:输卵管妊娠患者术后重复性异位妊娠不可忽视,而对于存在不孕史、盆腔感染史、异位妊娠史、输卵管手术史、输卵管双侧粘连及闭锁以及开腹手术的输卵管妊娠手术患者则应及时治疗不孕症,尽可能选择腹腔镜手术来降低患者术后重复性异位妊娠,以此提高患者术后生育能力。     

B超诊断子宫异位妊娠48例分析

异位妊娠是妇产科急腹症中常见的疾病。及时准确诊断极为重要．如临床诊断不明确．会耽误病情，而导致大出血。甚至危及患者生命。我院2004年6月～2008年6月诊断为子宫异位妊娠48例。现对其所具有的特殊性声像图改变分析报告如下。     

IUD合并异位妊娠10例报告

宫内节育器(IUD),是一种安全、可靠、方便、经济的避孕方法,全世界约有6千多万人应用,其中我国使用者已超过70％。随着IUD的推广。宫外孕的发生率明显上升。目前,宫外孕已成为危及妇女健康的一种特殊类型的疾病,即使在发达国家也是孕妇的死亡原因之一,因此,宫外孕的发生与使用IUD之间有一定的关系,所以,引起我们的高度重视。1 临床资料: 我站自1996年～2001年共收治异位妊娠28例,其中带器妊娠10例,发病率占35.7％。年龄最     

重复异位妊娠临床分析

目的:探讨首次异位妊娠不同处理方式与重复异位妊娠的发病因素及结局。方法:回顾性调查,2005年1月~2013年12月,我院326例异位妊娠,其中筛除双侧输卵管切除或绝育术者20例,年龄巳达绝经期者2例,对294例重复异位妊娠、异位妊娠发生的情况,以及首次异位妊娠的治疗方法进行分析,重复异位妊娠中前末次妊娠的情况,重复异位妊娠与首次异位妊娠所见输卵管炎症情况之间的关系。结果:294例弄位妊娠中发生重复异位妊娠27例,发生率9%,手术治疗(开腹清除病例输卵管,不包括切除或结扎对侧输卵量)96例,发生重复异位妊娠17例,发生率15.9%。药物保守治疗(指M·T·X分次肌注加中药口服外敷治疗)组192例,发生重复宫外孕12例,发生率5.2%,两者间差异有显著性(P0.05)。输卵管有肉眼炎症表现者85%病例重复异位妊娠发生在炎症侧,而重复异位妊娠发生在无肉眼炎症侧者仅为34%(P0.01)。结论:输卵管炎症与手术治疗异位妊娠是重复异位妊娠的危险因素,药物保守治疗发生重复异位妊娠率要比手术治疗发生重复异位妊娠率要低。     

天花粉蛋白治疗异位妊娠12例疗效观察

异位妊娠是妇科的急腹症之一 ,以输卵管妊娠最常见 ,占 95%以上 [1]。我站 1 995年 1 0月至 1 998年 1 0月 ,应用天花粉蛋白保守治疗早期输卵管妊娠 1 2例 ,效果良好。现报道如下。1　临床资料1 .1　一般资料　 1 2例异位妊娠患者 ,年龄在 2 4～40岁 ,平均 32岁。其中首次妊娠 2例 ,孕 2～ 3次6例 ,带器妊娠 2例 ,绝育手术后妊娠 2例。身体状况良好 ,估计输卵管妊娠未破裂或内出血少 ,无应用天花粉蛋白禁忌症。1 .2　症状与体征　停经 34～ 62天 ,其中停经 <50天 8例 ,>50天 3例 ,1例无停经史。均有阵发性腹痛 ,肛内坠胀感 ,阴道呈点滴状出…     

Endometrium implantation and ectopic pregnancy

Embryo in uterine implantation is a complex and multifactor-related process and is a downstream and ideal point for woman fertility control.Understanding the cellular and molecular mechanism of implantation is a prerequisite for development of anti-implantation contraceptives.In spite of considerable accumulation of information from the laboratory animals that has been achieved,it is difficult to generate such information in human due to ethical restriction and experimental limitation,and the present knowledge for understanding the definitive mechanisms which control these events remains elusive.Embryo implantation can also occur outside uterus.Some women with abdominal pregnancies could successfully complete the processes of gestation and bear normal babies,implying that implantation itself may be not an endometrium-specific process.Reproductive biologists should cooperate with gynecologists to further comparatively study the molecular and cellular mechanisms of implantation normally occurring in endometrium and abnormally appearing outside uterine cavity.Such collaborative studies may generate new important information for developing anti-implantation contraceptive and for techniques of accurate diagnosis of ectopic pregnancy.A specially designed GnRH-2 analog and a combination use of Iow dose RU486 and gossypol as anti-implantation contraceptives have been suggested.     

Endometrium implantation and ectopic pregnancy

~~Endometrium implantation and ectopic pregnancy~~     

Assessment of DNA damage in relation to heavy metal induced oxidative stress in females with recurrent pregnancy loss (RPL)

Pregnancy termination consecutively for three or more times during the first trimester is termed as Recurrent pregnancy loss (RPL). In addition to the abnormal karyotype, heavy metal induced oxidative damage may contribute as prominent etiological factor in pregnancy termination. Oxidative stress is considered crucial in etiology underlying RPL with altered antioxidant status and subsequent DNA damage. The current case controlled study investigated Total antioxidant capacity (TAC), DNA damage (8OHdG) and heavy metals in RPL group (n = 30) and the women with successful pregnancies and no cases of miscarriage as control group (30 women). Heavy metals -Antimony (Sb) and Arsenic (As) were measured by Inductively Coupled Plasma Mass spectrophotometry (ICP-MS). There was significant decrease in levels of TAC in RPL group compared to healthy pregnant women (P < 0.05). On contrary, elevated levels of As and Sb were observed in RPL group with subsequent increase in the levels of 8OHdG (P < 0.001); indicating extensive DNA damage in these patients. Furthermore, increased levels of As and Sb in RPL group were positively correlated with 8OHdG and negatively with total antioxidant capacity. The outcome of the study provides clear insight of the role of metal induced oxidative stress that plays a vital role in the pathophysiology underlying RPL.     

Evaluation of etiology and pregnancy outcome in recurrent miscarriage patients

The purpose of this study was to evaluate etiology and pregnancy outcome of recurrent miscarriage women. The enrolled patients (280) were evaluated for Triiodothyronine, Thyroxine, Thyroid stimulating hormone, prolactin, chromosomal analysis, Haemoglobin A1C, blood sugar, Magnetic resonance imaging, 3D-ultrasound, auto-antibodies profile (antiphospholipid antibodies, anticardiolipin antibodies, lupus anticoagulant, antinuclear antibodies, anti-thyroid antibodies and β2 glycoprotein1), torch profile (Toxoplasmo gondii, rubella, cytomegalo virus and herpes simplex virus), blood vitamin D3 levels, psychological factors, Body mass index and thrombotic factors (protein S and C deficiency, Prothrombin G20210A mutation, anti-thrombin III, Factor V Leiden and Methylenetetrahydrofolate reductase mutation), uterosalpingography (hysteronsalpingography) and hysteroscopy. The therapeutic regimens either singly or combined were employed for the treatment of recurrent miscarriage patients on the basis of etiology (single or multiple) and include intravenous immunoglobulin, low molecular weight heparin, low dose aspirin, levothyroxine, progesterone, folic acid, human chorionic gonadotrophin, vitamin D3, psychotherapy, genetic counselling. However, patients with idiopathic recurrent miscarriage were treated with progesterone supplementation, anticoagulation and/or immune modulatory agents. The incidence of primary recurrent miscarriage was highest and most of the women experienced recurrent miscarriage during first trimester. Endocrinological disorders (39%) were found as the major pathological factor for recurrent miscarriage. Other factors include uterine abnormalities (5.7%), vitamin D3 deficiency (3.5%), psychological factors (3.2%) infection (3.6%), autoimmune abnormalities (1.8%) and protein S deficiency (1.8%). However, 40% cases were idiopathic. The overall live birth rate achieved after the management of recurrent miscarriage patients was 75.7%. Enocrinopathy was the major cause of recurrent miscarriage. The overall live birth rate achieved was 75.7% with highest pregnancy outcome in secondary recurrent miscarriage patients after the management.     

输卵管通水术268例临床分析

目的:探讨输卵管炎性不孕症通水试验的诊断及治疗的临床意义。方法:回顾分析对268例输卵管炎性不孕患者行输卵管通水术后的疗效。结果:来我院进行通水试验治疗的268例输卵管炎性不孕症患者,其中原发性不孕症67例,占发病总数的25%;继发性不孕201例,占75%。经通水反复局部药物治疗,严重者加全身治疗后,输卵管完全通畅者244例,成功率91.04%,术后随访宫内妊娠238例,有效治愈率达88.81%;发生异位妊娠3例,占1.12%。仅有24例经通水治疗无效后行输卵管碘油造影,术后宫内妊娠4例。输卵管通水治疗当月受孕占14.2%。结论:输卵管通水术是诊断和治疗输卵管炎性不孕症的有效方法,早期性生活是否有利于输卵管功能的恢复,有待进一步探讨。     

氨甲喋呤不同给药途径治疗异位妊娠疗效分析

目的:探讨氨甲喋呤不同给药途径治疗异位妊娠的临床疗效。方法:将符合保守治疗指征的111例异位妊娠患者随机分成两组,A组57例采用氨甲喋呤50 mg肌注,B组54例为静脉滴注,两组均隔日一次用药共三次,次日加用甲酰四氢叶酸钙解毒6 mg,肌注共三次,定期测定血β-HCG至正常。结果:两组共有97例成功,总成功率为87.39％,其中A组有49例获得成功,成功率为85.96％,B组有48例获得成功,成功率为88.89％,两组成功率无显著性差异,P>0.05。结论:合理选择保守治疗的对象严格掌握适应症是MTX保守治疗成功的关键,至于MTX的两种不同给药途径所得疗效无明显差异。     

Joint analysis of longitudinal data and recurrent episodes data with application to medical cost analysis

This paper discusses regression analysis of longitudinal data in which the observation process may be related to the longitudinal process of interest. Such data have recently attracted a great deal of attention and some methods have been developed. However, most of those methods treat the observation process as a recurrent event process, which assumes that one observation can immediately follow another. Sometimes, this is not the case, as there may be some delay or observation duration. Such a process is often referred to as a recurrent episode process. One example is the medical cost related to hospitalization, where each hospitalization serves as a single observation. For the problem, we present a joint analysis approach for regression analysis of both longitudinal and observation processes and a simulation study is conducted that assesses the finite sample performance of the approach. The asymptotic properties of the proposed estimates are also given and the method is applied to the medical cost data that motivated this study.