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1.
New pheophorbide and pyropheophorbide derivatives containing carbohydrate fragments, derivatives of galactopyranose, were synthesized. Galactopyranosylpheophorbide and galactopyranosylpyropheophorbide with free hydroxyl groups were found to be water-soluble and useful as sensitizers in photodynamic therapy of cancer. 相似文献
2.
A. A. Aksenova Yu. L. Sebyakin A. F. Mironov 《Russian Journal of Bioorganic Chemistry》2000,26(2):111-114
New pheophorbide and pyropheophorbide derivatives containing carbohydrate fragments, derivatives of galactopyranose, were
synthesized. Galactopyranosylpheophorbide and galactopyranosylpyropheophorbide with free hydroxyl groups were found to be
water-soluble and useful as sensitizers in photodynamic therapy of cancer.
This article is dedicated to the 25th Anniversary of the journal Bioorganicheskaya Khimiya 相似文献
3.
2,3,1',3'4',6'-Hexa-O-benzylsucrose was obtained by mild acid-catalysed hydrolysis of the 4,6-O-isopropylidene derivative and then converted into its 4,6-di-O-mesyl derivative. Selective displacement of this disulphonate with fluoride anion (from tetrabutylammonium fluoride) then afforded the 6-fluoro-4-mesylate. Removal of the protecting groups yielded 6-deoxy-6-fluorosucrose, which was characterised as its crystalline hepta-acetate. A derivative of 6-deoxy-6-fluoro-galacto-sucrose was formed when the above 6-fluoro-4-mesylate was subjected to nucleophilic displacement with benzoate anion. 相似文献
4.
Derivatives (the 3-acetamido-4-benzoate 12, the 3-acetamido-4-acetate 13, and the N-acetyl derivative 14) of the methyl glycoside of the title sugar were prepared in a sequence of high-yielding steps from methyl 3-azido-4,6-O-benzylidene-2,3-di-deoxy-α-d-arabino-hexopyranoside (4). N-Bromosuccinimide converted 4 into the crystalline 4-O-benzoyl-6-bromide 5, which was treated with silver fluoride to afford the 5,6-unsaturated glycoside 6. Catalytic hydrogenation of 6 led, essentially, to a 7:1 mixture of 12 and its 5-epimeric d-arabino isomer 7. Alternatively, 6 was debenzoylated to 10, and the latter treated with lithium aluminum hydride to give crystalline methyl 3-amino-2,3,6-trideoxy-α-d-threo-hex-5-enopyranoside (11). Reduction of 11 (as its salt) by hydrogen, with subsequent N-acetylation, furnished the methyl β-l-xylo-glycoside 13 almost exclusively, with net inversion at C-5. Compound 13 was readily converted into the crystalline target compound 14. When dehydrobromination by silver fluoride was attempted with the 3-acetamido analog (2) of 5, a 3,6-anhydro product (1) was obtained, instead of the expected 5,6-alkene 3. 相似文献
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The coupling of N-succinimide esters of 3-[7-hydroxy-3-(4-methyl-1,3-thiazol-2-yl)-6-ethyl-4-oxo-4H-chromen-2-yl]propanoic acid and 5-carboxymethyl-6-azauracil with free arginine yielded the corresponding arginine derivatives, which were purified by crystallization. The structures of the compounds were confirmed by 1H NMR spectroscopy. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2006, vol. 32, no. 3; see also http://www.maik.ru. 相似文献
7.
A. A. Poyarkov M. S. Frasinyuk V. K. Kibirev S. A. Poyarkova 《Russian Journal of Bioorganic Chemistry》2006,32(3):277-279
The coupling of N-succinimide esters of 3-[7-hydroxy-3-(4-methyl-1,3-thiazol-2-yl)-6-ethyl-4-oxo-4H-chromen-2-yl]propanoic acid and 5-carboxymethyl-6-azauracil with free arginine yielded the corresponding arginine derivatives, which were purified by crystallization. The structures of the compounds were confirmed by 1H NMR spectroscopy 相似文献
8.
O. B. Kazakova E. V. Tret’yakova I. E. Smirnova L. V. Spirikhin G. A. Tolstikov I. V. Chudov G. V. Bazekin A. F. Ismagilova 《Russian Journal of Bioorganic Chemistry》2010,36(2):257-262
Under the action of PCl5, the Beckman rearrangement of a 3: 1 mixture of Z- and E-isomeres of 18β-hydro-xydihydroquinopimaric acid resulted in 5′-caprolactam and isomeric caprolactams containing fragments
of cyclic ether. Z- and E-ketoximes were separated as acetates. Using a carrageenan inflammation model, we demonstrated that the anti-inflammatory
activity of quinopimaric acid derivatives was comparable with that of diclofenac. 相似文献
9.
E. A. Rozhkova A. I. Lysko K. V. Kuleshov R. P. Evstigneeva 《Russian Journal of Bioorganic Chemistry》2000,26(6):419-422
New derivatives of proto- and deuterohemin IX containing tri- and tetrazole rings were synthesized and characterized. A pronounced
antioxidant activity was found for these compounds in the Fe(II)/ascorbate-dependent system of lipid peroxidation in murine
liver homogenates. 相似文献
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11.
Ronald Eby 《Carbohydrate research》1979,70(1):75-82
2-[4-(p-Toluenesulfonamido)phenyl]ethyl 2,3,4-tri-O-benzyl-α-D-glucopyranoside was condensed with 2,3,4-tri-O-benzyl-6-O-(N-phenylcarbamoyl)-1-O-tosyl-D-glucopyranose to give 2-[4-(p-toluenesulfonamido)phenyl]ethyl 2,3,4,2′,3′,4′-hexa-O-benzyl-6′-O-(N-phenylcarbamoyl)α-isomaltoside. The disaccharide was decarbanilated in ethanol with sodium ethoxide. The sequence of coupling with the 1-O-tosyl-glucose derivative followed by decarbanilation was repeated to form the tri- and tetra-saccharide derivatives. The di-, tri-, and tetra-oligo-saccharides, were deblocked with sodium in liquid ammonia to give the 2-(4-aminophenyl)ethyl α-isomalto-oligosaccharides, which were diazotized with sodium nitrite in acid, and then coupled to bovine serum albumin and edestin to give the protein conjugates. 相似文献
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13.
《Bioorganic & medicinal chemistry letters》2020,30(16):127351
A series of new 5-alkynyl-substituted uracil and uridine derivatives were synthesised via palladium-catalysed Sonogashira cross-coupling reaction of 5-bromo-pyrimidine base with terminal acetylenes with good yields in DMF at room temperature. All obtained compounds were tested for antimycobacterial activity against Mycobacetrium bovis and Mycobacterium tuberculosis (H37Ra) at concentrations of 1–100 µg/ml using MABA test. Obtained results revealed that most of tested uracil derivatives exhibited high antimycobacterial activity (MIC50 = 1.1–19.2 µg/ml) in comparison with therapeutic agents such as rifampicin, isoniazid and d-cycloserine, excluding compounds having alkyl substituent at triple alkyne bond. 相似文献
14.
A facile synthesis of sugar-pyrazole derivatives has been accomplished by condensation of sugar-chalcone with hydrazine hydrate under neutral conditions resulting in yields of 70–85%. The products are characterized by FTIR and NMR spectroscopy and by elemental analysis. The β-anomeric forms for these derivatives were assigned by NMR spectroscopy. 相似文献
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17.
Subbiah Nagarajan 《Carbohydrate research》2009,344(8):1028-2336
Seven different sugar-quinoline derivatives were synthesised in a ‘one-pot’ reaction from their corresponding C-β-glycoside derivatives. The compounds were characterised by NMR spectroscopy and elemental analysis. 相似文献
18.
Katritzky AR Angrish P Todadze E Ghiviriga I 《Bioorganic & medicinal chemistry letters》2007,17(21):6000-6002
N-Z-pyroglutamyl pseudopeptides 3a-c are shown to be conveniently prepared from glutamyl-bis-Bt 1a by cyclization of an N-terminal glutamic acid residue. Structures are supported by 2D NMR studies and by comparison with the same products prepared by direct coupling of the C-terminus activated N-pGlu 1b and free amino acids 2a-c. 相似文献
19.
Tomasz Ruman Karolina D?ugopolska Katarzyna Rydel Wojciech Rode 《Bioorganic chemistry》2010,38(3):87-91
Preparation and spectroscopic properties of novel boron-containing derivatives of anti-HIV agent stavudine are presented, The new compounds, (5′-O-(4,4,5,5-tetramethyl-1,3,2-dioxaboronate)-2′-3′-didehydro-2′-3′-dideoxythymidine and 5′-O-(dihydroxyboronate)-2′-3′-didehydro-2′-3′-dideoxythymidine), were prepared by direct reaction between stavudine and reagents containing BH moieties - pinacolborane and borane-dimethylsulfide complexes, respectively. The boron coordination equilibrium of those compounds was analyzed by water titration monitored by NMR. Results of the DFT calculations and NMR experiments pointed to structural and electronic similarity of tetrahedral boron complexes to phosphate group. 相似文献
20.
Mikel P. Moyer Frederick H. Weber Jonathan L. Gross Joseph W. Isaac Ralph Saint Fort 《Bioorganic & medicinal chemistry letters》1992,2(12):1589-1594
The synthesis of a number of 4,6-diaminoquinoline derivatives is described as well as their evaluation in a mouse protection model designed to identify immunostimulant activity. These compounds represent a novel series of potent immunostimulants. 相似文献