共查询到20条相似文献,搜索用时 31 毫秒
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Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin 总被引:1,自引:0,他引:1
Jain N Gupta S Sudhakar Ch Radha V Swarup G 《The Journal of biological chemistry》2005,280(44):36664-36673
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S Kubicka F Kühnel L Zender K L Rudolph J Plümpe M Manns C Trautwein 《The Journal of biological chemistry》1999,274(45):32137-32144
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Transcriptional activation of p53 by Pitx1 总被引:1,自引:0,他引:1
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Jiang J Chen X Shen J Wei Y Wu T Yang Y Wang H Zong H Yang J Zhang S Xie J Kong X Liu W Gu J 《The Journal of biological chemistry》2006,281(14):9482-9489
beta1,4-galactosyltransferase V (GalT V; EC 2.4.1.38) can effectively galactosylate the GlcNAcbeta1-->6Man arm of the highly branched N-glycans that are characteristic of glioma. Previously, we have reported that the expression of GalT V is increased in the process of glioma. However, currently little is known about the role of GalT V in this process. In this study, the ectopic expression of GalT V could promote the invasion and survival of glioma cells and transformed astrocytes. Furthermore, decreasing the expression of GalT V in glioma cells promoted apoptosis, inhibited the invasion and migration and the ability of tumor formation in vivo, and reduced the activation of AKT. In addition, the activity of GalT V promoter could be induced by epidermal growth factor, dominant active Ras, ERK1, JNK1, and constitutively active AKT. Taken together, our results suggest that GalT V functioned as a novel glioma growth activator and might represent a novel target in glioma therapy. 相似文献
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《Cell cycle (Georgetown, Tex.)》2013,12(18):2856-2867
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p21/CDKN1A mediates negative regulation of transcription by p53 总被引:11,自引:0,他引:11
Löhr K Möritz C Contente A Dobbelstein M 《The Journal of biological chemistry》2003,278(35):32507-32516
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