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Mapping the DNA binding domain of the Zap1 zinc-responsive transcriptional activator 总被引:6,自引:0,他引:6
Bird A Evans-Galea MV Blankman E Zhao H Luo H Winge DR Eide DJ 《The Journal of biological chemistry》2000,275(21):16160-16166
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A role in DNA binding for the linker sequences of the first three zinc fingers of TFIIIA. 总被引:8,自引:0,他引:8 下载免费PDF全文
Zinc fingers of the TFIIIA type are connected by short linker sequences between the structural units. Structural investigations by 2D NMR in solution and by X-ray crystallographic analyses of complexes with DNA point to a passive role for the linkers. We have therefore investigated the influence of the linker sequence on DNA binding using as a model the first three fingers of the protein TFIIIA. Insertion of certain heterologous linkers abolishes binding, and replacement of individual amino acids can reduce binding by factors of up to twenty-four. 相似文献
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RNA and DNA binding zinc fingers in Xenopus TFIIIA. 总被引:4,自引:0,他引:4
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