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1.
《Inorganica chimica acta》1988,154(1):89-93
[Pt(COD)Cl2] (COD=1,5-cyclooctadiene) is a versatile starting material for the synthesis of Pt(II) compounds. The preparations of the new compounds [Pt(COD)Cl(NO3)], [Pt(COD)(NO3)2] and [Pt(PPh3)3(NO3)](NO3) and also of the known compounds cis[Pt(PPh3)2Cl2], cis [Pt(PPh3)2Cl(NO3)], cis[Pt(PPh3)2(NO3)2] and [Pt(PPh3)3Cl](NO3)are reported. The compounds are characterized by elemental analysis, 31P{1H} NMR spectroscopy and IR spectroscopy. 相似文献
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Elena N. Kalinichenko Elena B. Rubinova Evgueny V. Borisov Jan Balzarini Erik De Clercq Igor A. Mikhailopulo 《Nucleosides, nucleotides & nucleic acids》2013,32(3-5):533-536
Abstract Reaction of 1-[2,5(and 3,5)-di-O-trityl-β-D-erythro-pentofuran-3 (and 2)-ulosyl]uracil derivatives 5 and 6 with (chloromethyl)triphenylphosphorane resulted in the stereoselective formation of (E)-3′- and (Z)-2′-chloromethylene derivatives 7 (69%) and 8 (53%), respectively, deprotection of which gave 9 and 10. Transformation of the uracil nucleoside 7 into cytosine one followed by deprotection yielded 12. The latter was converted into the arabinoside 14. The fully deprotected chloromethylene nucleosides were tested for their activity against HIV-1 and HIV-2. 相似文献
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Fumio Sugawara Haruhiko Nakayama Gary A. Strobel Tomoya Ogawa 《Bioscience, biotechnology, and biochemistry》2013,77(9):2261-2271
The stereoselective synthesis of 1- and 2-O-α-d-cellotriosyl-3-deoxy-2(R)- and 2(S)-glycerols, which determined the structure of rhynchosporoside produced by Rhynchosporium secalis, and their phytotoxicity toward the host plant (Hordeum vulgare) are described in detail. 相似文献
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Stella Manta Vanessa Parmenopoulou Christos Kiritsis Athina Dimopoulou Nikolaos Kollatos Ioannis Papasotiriou 《Nucleosides, nucleotides & nucleic acids》2013,32(7):522-535
This article describes the synthesis of (3 ′S) and (3 ′R)-3 ′-amino-3 ′-deoxy pyranonucleosides and their precursors (3 ′S) and (3 ′R)-3 ′-azido-3 ′-deoxy pyranonucleosides. Azidation of 1,2:5,6-di-O-isopropylidene-3-O-toluenesulfonyl-α-D-allofuranose followed by hydrolysis and subsequent acetylation afforded 3-azido-3-deoxy-1,2,4,6-tetra-O-acetyl-D-glucopyranose, which upon coupling with the proper silylated bases, deacetylation, and catalytic hydrogenation, obtained the target 3 ′-amino-3 ′-deoxy-β-D-glucopyranonucleosides. The desired 1-(3 ′-amino-3 ′-deoxy-β-D-allopyranosyl)5-fluorouracil was readily prepared from the suitable imidazylate sugar after azidation followed by a protection/deprotection sequence and reduction of the unprotected azido precursor. No antiviral activity was observed for the novel nucleosides. Moderate cytostatic activity was recorded for the 5-fluorouracil derivatives. 相似文献
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《Inorganica chimica acta》1988,153(1):51-55
The structures of three Pt(II) thiourea complexes, trans-[(tu)2Pt(NH3)2]Cl2 (1), trans-[(tu)2Pt(CH3NH2)2]Cl2·3H2O (2) and [Pt(tu)4]Cl2 (3), have been determined by X-ray diffraction and refined to R = 0.049 for 1026 reflections (1), R = 0.057 for 2547 reflections (2) and R = 0.046 for 2792 reflections (3). All the compounds crystallize in the space group P21/c and have cell dimensions: a = 5.437(1), b = 6.450(1), c = 17.980(3) Å, β = 96.05(2)°, Z = 2 (compound 1); a = 9.225(1), b = 15.404(2), c = 12.601(2) Å, β = 105.39(2)°, Z = 4 (compound 2); and a = 9.051(6), b = 10.203(6), c = 18.263(8) Å, β = 91.12(8)°, Z = 4 (compound 3). The unit cell of 1 and 3 contains only a single type of cation, while that of 2 is formed from two independent cations. In 1 and 2 the coordination spheres of the Pt atoms are rather similar, with angles close to 90° and coplanarity of the metal and respective donor atoms. Instead, in 3 the four sulfur atoms, which surround the Pt, display a slight distortion (0.06 Å from the mean plane) towards tetrahedral. 相似文献
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《Inorganica chimica acta》2006,359(9):2751-2755
The compounds Cp2Ce[η3-N(QPPh2)2] (Q = S (1), Se (2)) and Cp2Ce[η3-N(SPiPr2)(SePPh2)] (3) have been synthesized from the protonolysis reactions between Cp3Ce and HN(QPPh2)2 or HN(SPiPr2)(SePPh2) in THF. The structures of these compounds have been determined by X-ray crystallographic methods. The three compounds have similar structures in which the ligands are coordinated to Cp2Ce moiety in an η3 fashion through the two chalcogen atoms and an N atom. Whereas the 77Se NMR resonances are normal the 31P NMR resonances are shifted to much lower frequencies than in similar rare-earth compounds. 相似文献
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《Inorganica chimica acta》1988,143(2):185-192
Ta2Cl6(SMe2)3 reacts with PhHNNHPh to afford Ta2Cl4(μ-Cl)2(μ-PhN)(PhNH2)3 (1) a compound with a TaIVTaIV single bond, with a length of 2.644(1) Å. The compound crystallizes in space group Pnma with unit cell dimensions a = 22.960(8), b = 16.875(4), c = 6.367(3) Å, V = 2467(1) Å3, and Z = 4. The reaction of Nb2Cl6(SMe2)3 with PhHCNNCHPh, merely on mixing at room temperature produced Nb2Cl6(SMe2) [PhHC(N)PhHCNHNCHPh]·C7H8 (2) as large red crystals in ca. 50% yield. The molecule consists of two NbIV atoms, one six-coordinate and the other seven-coordinate, united by three bridging atoms (Cl, Cl, N) and a NbNb bond of length 2.681(1) Å. The way in which the tridentate triazo ligand is generated is completely obscure. Crystallographic data for 2: space group P21/n with a = 11.393(3), b = 11.988(3), c = 27.233(7) Å, β = 100.75(2)°, V = 3654(3) Å, and Z = 4. 相似文献
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《Inorganica chimica acta》1988,147(2):243-250
The acetone complex [Rh(H)2(acetone)2(PPh3)2]- PF6 reacts with bidiazines and 3,6-bis(2′-pyridyl)- pyridazine (dppn) giving the air stable cis-dihydrido rhodium(III) [Rh(H)2(L)(PPh3)2]PF6 complexes. The structure of the dichloromethane solvate of [Rh(H)2(dppn)(PPh3)2]PF6 has been determined by X-ray crystal structure analysis. Crystals are monoclinic, space group P21/a, with a = 18.629(6), b = 15.339(5), c = 17.146(5) Å, β = 101.02(3)° and Z = 4. The structure has been solved from diffractometer data by Patterson and Fourier methods and refined by block-matrix least-squares to R = 0.076 for 6225 observed reflections. In the structure discrete [Rh(H)2(dppn)(PPh3)2]+ cationic complexes, PF6− anions and dichloromethane solvent molecules are present. The Rh atom is octahedrally surrounded by two cis hydride ligands and by two cis nitrogen atoms from a dppn molecule acting as a bidentate chelating ligand through two neighbouring pyridyl and pyridazinyl nitrogen atoms. Two P atoms from PPh3, ligands in trans apical positions complete to octahedral the coordination of Rh. 相似文献
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《Inorganica chimica acta》1986,117(1):45-48
The resonance Raman spectra of K2(Ti(O2)(SO4)2)·5H2O and K2(Ti(O2)(C2O4)2)·3H2O are recorded. The results are consistent with the triangular structure of the peroxotitanium unit, Ti(O2), with C2ν symmetry. The ν(OO), νs(TiO) and νas(TiO) are observed around 890, 610 and 535 cm−1, respectively. The resonance effects are shown to be associated with the 425 nm absorption band. This band is assigned to the O22− → Ti(IV) charge-transfer transition. The calculated force constant values for the O22− and TiO bonds are 320 and 275 N m−1, respectively. 相似文献
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《Bioorganic & medicinal chemistry》2014,22(21):6105-6111
Isoflavones are bioactive compounds that have been shown to decrease lipid accumulation in vitro. However, the knowledge of the isoflavone formononetin is limited. The aim of the study was to assess the effects of formononetin and its two synthetic analogues, 2-(2-bromophenyl)-formononetin and 2-heptyl-formononetin, on lipid accumulation in 3T3-L1 adipocytes and investigate possible mechanisms. Formononetin and the two analogues were added day 0–8 or day 8–10 of the differentiation period, and lipid accumulation, glycerol release and gene expression were measured. Additionally, competitive peroxisome proliferator-activated receptor (PPAR)-γ binding assay, PPARγ transactivation assay and Western blot for phosphorylated AMP-activated protein kinase (AMPK) were performed. Chronic treatment (day 0–8) with formononetin increased lipid accumulation, whereas the two analogues decreased lipid accumulation partly due to decreased differentiation. The two analogues, but not formononetin, also decreased lipid content in mature adipocytes. 2-Heptyl-formononetin increased glycerol release and lipolytic gene expression and decreased lipogenic gene expression. Formononetin did not bind to or activate PPARγ whereas both analogues bound to the receptor and behaved as PPARγ partial agonists in the transactivation assay. Neither of the compounds affected phosphorylation of AMPK. In conclusion, the analogues of formononetin decreased lipid accumulation possibly in part by acting as PPARγ partial agonists. 相似文献
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Reaction of the ligand N-methyl-N-((6-pivaloylamido-2-pyridyl)methyl)-N-(2-pyridylethyl)amine (mpppa) with equimolar amounts of [Cu(H2O)6][ClO4]2 or CuCl2 · 2H2O in MeCN afforded mononuclear copper(II) complexes [Cu(mpppa)][ClO4]2 (1) and [Cu(mpppa)Cl2] (2). Crystal structure analysis reveals CuN3O (two pyridyl, an aliphatic amine, and an amide oxygen) coordination in 1 and CuN3Cl2 (two pyridyl, an aliphatic amine, and two chlorides) coordination in 2. Crystal packing diagram of 1 reveals that one of the perchlorate counteranions provides weak coordination to copper(II) centers and in turn the copper(II) centers assume pseudo-six-coordination, generating 1D chain. Notably, one of the copper(II)-coordinated chloride ions in 2 participates in an intramolecular N–H?Cl interaction. Intermolecular C–H?Cl interactions in the solid state generate helical structure. Spectroscopic (IR, UV–Vis, and EPR) and redox properties of the two complexes have been investigated and compared. 相似文献
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Nicole Rempel Sibilla Heyers Hartmut Engels E. Sleegers O. K. Steinlein 《Human genetics》1998,103(6):645-653
The α4-subunit gene (CHRNA4) of the neuronal nicotinic acetylcholine receptor (nAChR) subunit family has recently been identified in two families as
the gene responsible for autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), a rare monogenic idiopathic epilepsy.
As a result of this finding, other subunits of the neuronal nAChR gene family are being considered as candidate genes for
ADNFLE in families not linked to CHRNA4 and for other idiopathic epilepsies. α4-subunitsoften assemble together with β2-subunits (gene symbol CHRNB2) to build heteromeric nAChRs. The gene encoding another abundant AChR subunit, the α3-subunit gene (CHRNA3), is present with those encoding two other subunits, CHRNB4 and CHRNA5, in a gene cluster whose functional role is still
unclear. Here we provide the information on the genomic structures of both the CHRNB2 and the CHRNA3 genes that is necessary for comprehensive mutational analyses, and we refine the genomic assignment of CHRNB2 on chromosome 1.
Received: 5 August 1998 / Accepted: 13 October 1998 相似文献