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1.
Unit responses in the primary auditory cortex of anesthetized cats to stationary and apparently moving stimuli resulted from a static and dynamically varying interaural delay (ITD) were recorded. The static stimuli consisted of binaurally presented tones and clicks. The dynamic stimuli were produced by in-phase and out-of-phase binaurally presented click trains with time-varying ITD. Sensitivity to ITDs was mostly seen in responses of the neurons with low characteristic frequency (below 2.8 kHz). All cells sampled with static stimuli responded to simulated motion. A motion effect could take the form of a difference in response magnitude depending on the direction of stimulus motion and a shift in the ITD-function opposite the direction of motion. The magnitude of motion effects was influenced by the position of motion trajectory relative to the ITD-function. The greatest motion effect was produced by motion crossing the ITD-function slopes.  相似文献   

2.
The EPs of the inferior colliculus and auditory cortex in anaesthetized guinea pigs and the long latency auditory EPs in alert humans were studied. The stimuli consisted of binaurally presented pairs of clicks used as a masker, and the probe, with a variable time delay between them. The greatest relative differences between out-of-phase and in-phase probe responses were observed at the beginning of the recovery course. They averaged as 1.6, 1.5 and 1.4 for the responses of the inferior colliculus, auditory cortex and long latency potentials, resp., at the stimuli intensities of 50-65 dB SPL, and then decreased to zero during the time course of the probe response recovery. Correlation of this parameter with the stimulus intensity was positive.  相似文献   

3.
Auditory brainstem responses (ABRs), middle latency responses (MLRs), and slow cortical potentials (SCPs) were recorded in normal-hearing adults to trains of low-frequency acoustic signals delivered binaurally against a background of a continuous masking noise. Two stimulus conditions, labelled as binaural homophasic and binaural antiphasic paradigms, respectively, were systematically compared. In the homophasic paradigm both the signals and the masker were in-phase at two ears. In the antiphasic paradigm the signals were 180 degrees out-of-phase at two ears, while the masker was in-phase. The psychoacoustic release from masking in the antiphasic vs. the homophasic paradigm was regularly accompanied by an increase in amplitudes and a shortening in peak latencies of the SCPs. In contrast, no differences were evidenced between the homophasic and the antiphasic paradigms with respect to the ABRs and the MLRs. Considering the generation loci of the studied electric responses, it is concluded that the binaural psychoacoustic phenomenon, referred to as the masking level difference, is operated primarily at the cortical level.  相似文献   

4.
The binaural masking level difference (BMLD) is a psychophysical effect whereby signals masked by a noise at one ear become unmasked by sounds reaching the other. BMLD effects are largest at low frequencies where they depend on signal phase, suggesting that part of the physiological mechanism responsible for the BMLD resides in cells that are sensitive to interaural time disparities. We have investigated a physiological basis for unmasking in the responses of delay-sensitive cells in the central nucleus of the inferior colliculus in anaesthetized guinea pigs. The masking effects of a binaurally presented noise, as a function of the masker delay, were quantified by measuring the number of discharges synchronized to the signal, and by measuring the masked threshold. The noise level for masking was lowest at the best delay for the noise. The mean magnitude of the unmasking across our neural population was similar to the human psychophysical BMLD under the same signal and masker conditions.  相似文献   

5.
Spatial release from masking refers to a benefit for speech understanding. It occurs when a target talker and a masker talker are spatially separated. In those cases, speech intelligibility for target speech is typically higher than when both talkers are at the same location. In cochlear implant listeners, spatial release from masking is much reduced or absent compared with normal hearing listeners. Perhaps this reduced spatial release occurs because cochlear implant listeners cannot effectively attend to spatial cues. Three experiments examined factors that may interfere with deploying spatial attention to a target talker masked by another talker. To simulate cochlear implant listening, stimuli were vocoded with two unique features. First, we used 50-Hz low-pass filtered speech envelopes and noise carriers, strongly reducing the possibility of temporal pitch cues; second, co-modulation was imposed on target and masker utterances to enhance perceptual fusion between the two sources. Stimuli were presented over headphones. Experiments 1 and 2 presented high-fidelity spatial cues with unprocessed and vocoded speech. Experiment 3 maintained faithful long-term average interaural level differences but presented scrambled interaural time differences with vocoded speech. Results show a robust spatial release from masking in Experiments 1 and 2, and a greatly reduced spatial release in Experiment 3. Faithful long-term average interaural level differences were insufficient for producing spatial release from masking. This suggests that appropriate interaural time differences are necessary for restoring spatial release from masking, at least for a situation where there are few viable alternative segregation cues.  相似文献   

6.
Summary This paper investigates the ability of neurons in the barn owl's (Tyto alba) inferior colliculus to sense brief appearances of interaural time difference (ITD), the main cue for azimuthal sound localization in this species. In the experiments, ITD-tuning was measured during presentation of a mask-probe-mask sequence. The probe consisted of a noise having a constant ITD, while the mask consisted of binaurally uncorrelated noise. Collicular neurons discriminated between the probe and masking noise by showing rapid changes from untuned to tuned and back to untuned responses.The curve describing the relation between probe duration and the degree of ITD-tuning resembled a leaky-integration process with a time constant of about 2 ms. Many neurons were ITD-tuned when probe duration was below 1 ms. These extremely short effective probe durations are interpreted as evidence for neuronal convergence within the pathway computing ITD. The minimal probe duration necessary for ITD-tuning was independent of the bandwidth of the neurons' frequency tuning and also of the best frequency of a neuron. Many narrowly tuned neurons having different best frequencies converge to form a broad-band neuron. To yield the short effective probe durations the convergence must occur in strong temporal synchronism.Abbreviations ICc central nucleus of the inferior colliculus; - ICx external nucleus of the inferior colliculus; - ITD interaural time difference - LP Likelihood parameter  相似文献   

7.
Neurons in the central nucleus of the inferior colliculus (IC) receive excitatory and inhibitory inputs from both lower and higher auditory nuclei. Interaction of these two opposing inputs shapes response properties of IC neurons. In this study, we examine the interaction of excitation and inhibition on the responses of two simultaneously recorded IC neurons using a probe and a masker under forward masking paradigm. We specifically study whether a sound that serves as a probe to elicit responses of one neuron might serve as a masker to suppress or facilitate the responses of the other neuron. For each pair of IC neurons, we deliver the probe at the best frequency (BF) of one neuron and the masker at the BF of the other neuron and vice versa. Among 33 pairs of IC neurons recorded, this forward masking produces response suppression in 29 pairs of IC neurons and response facilitation in 4 pairs of IC neurons. The degree of suppression decreases with recording depth, sound level and BF difference between each pair of IC neurons. During bicuculline application, the degree of response suppression decreases in the bicuculline-applied neuron but increases in the paired neuron. Our data indicate that the forward masking of responses of IC neurons observed in this study is mostly mediated through GABAergic inhibition which also shapes the discharge pattern of these neurons. These data suggest that interaction among individual IC neurons improves auditory sensitivity during auditory signal processing.  相似文献   

8.
Li AA  Chen QC  Wu FJ 《生理学报》2006,58(2):141-148
有关听中枢神经元纯音前掩蔽效应的神经表征已进行了大量研究,但是,噪声前掩蔽尤其是间断噪声前掩蔽效应的神经表征却鲜有报道。本研究观察了自由声场条件下,昆明小鼠下丘神经元在持续与间断噪声前掩蔽条件下对纯音探测声的反应。共记录到96个下丘神经元,测量了其中51个神经元在不同声刺激条件下的强度一放电率函数。结果显示,掩蔽声强度分布较广(探测声阈下21dB至阈上19dB之间)。在将近一半的神经元中,间断噪声的前掩蔽效应比持续噪声强(Ⅰ型,45.10%,P〈0.001),但也有少数神经元其间断噪声的掩蔽效应较持续噪声的弱(Ⅲ型,17.65%,P〈0.001),部分神经元无显著性差异(Ⅱ型,37.25%,P〉0.05)。无论Ⅰ型还是Ⅲ型神经元,持续噪声和间断噪声均在探测声强度较低时产生较强的抑制效应,随着探测声强度的升高,抑制效应逐渐降低(P〈0.001);同时,持续噪声和间断噪声之间前掩蔽效应差异亦不复存在(P〉0.05)。此外,当掩蔽声由持续噪声换为间断噪声后,部分Ⅰ型神经元掩蔽时相的类型发生转变,其中最主要的转变为由前期抑制转变为均衡抑制(53.85%,7/13)。对下丘神经元声反应的时间域以及强度域,持续与间断噪声具有分化性前掩蔽效应,提示噪声前掩蔽并非简单的神经元发放压抑源,某些主动性神经调制机制可能参与了噪声条件下时相声信息的编码过程。  相似文献   

9.
为探讨偏离神经元最佳频率(best frequency,BF)的声刺激对下丘神经元的前掩蔽效应,实验选用5只听力正常的几内亚长翼蝠(Miniopterus magnater),记录它们的下丘神经元对偏离BF的掩蔽声和探测声(BF)的反应.结果发现,当掩蔽声向高或低频方向偏离神经元的BF时,掩蔽效应逐渐降低.根据计算出的...  相似文献   

10.
Barn owls use interaural intensity differences to localize sounds in the vertical plane. At a given elevation the magnitude of the interaural intensity difference cue varies with frequency, creating an interaural intensity difference spectrum of cues which is characteristic of that direction. To test whether space-specific cells are sensitive to spectral interaural intensity difference cues, pure-tone interaural intensity difference tuning curves were taken at multiple different frequencies for single neurons in the external nucleus of the inferior colliculus. For a given neuron, the interaural intensity differences eliciting the maximum response (the best interaural intensity differences) changed with the frequency of the stimulus by an average maximal difference of 9.4±6.2 dB. The resulting spectral patterns of these neurally preferred interaural intensity differences exhibited a high degree of similarity to the acoustic interaural intensity difference spectra characteristic of restricted regions in space. Compared to stimuli whose interaural intensity difference spectra matched the preferred spectra, stimuli with inverted spectra elicited a smaller response, showing that space-specific neurons are sensitive to the shape of the spectrum. The underlying mechanism is an inhibition for frequency-specific interaural intensity differences which differ from the preferred spectral pattern. Collectively, these data show that space-specific neurons are sensitive to spectral interaural intensity difference cues and support the idea that behaving barn owls use such cues to precisely localize sounds.Abbreviations ABI average binaural intensity - HRTF head-related transfer function - ICx external nucleus of the inferior colliculus - IID interaural intensity difference - ITD interaural time difference - OT optic tectum - RMS root mean square - VLVp nucleus ventralis lemnisci laterale, pars posterior  相似文献   

11.
A model of bilateral information processing in the auditory system was presented on the basis of the interaction of postsynaptic potentials intra- and internuclei in order to analyze the mechanism of binaural unmasking as well as monaural masking. The system was composed of a bilateral pair of auditory nuclei, which were organized in two parallel afferent systems as well as an efferent system. In the model, bilateral inputs were processed in three stages, i.e., the detection of interaural differences by the first afferent system, the equalization of relative neural timing by the efferent system, and the cancellation of specific spectral components by the second afferent system. Assuming the masking process to be forward and backward inhibitions on the auditory memory of signal by the ones of noise, the unmasking process could be explained as a result of disinhibition by the cancellation of bilateral masker inputs.This study was supported in part by a Grant-in-Aid for Scientific Research (No. 59870082) from the Japanese Ministry of Education, Science, and Culture  相似文献   

12.
Contralateral masking is the phenomenon where a masker presented to one ear affects the ability to detect a signal in the opposite ear. For normal hearing listeners, contralateral masking results in masking patterns that are both sharper and dramatically smaller in magnitude than ipsilateral masking. The goal of this study was to investigate whether medial olivocochlear (MOC) efferents are needed for the sharpness and relatively small magnitude of the contralateral masking function. To do this, bilateral cochlear implant patients were tested because, by directly stimulating the auditory nerve, cochlear implants circumvent the effects of the MOC efferents. The results indicated that, as with normal hearing listeners, the contralateral masking function was sharper than the ipsilateral masking function. However, although there was a reduction in the magnitude of the contralateral masking function compared to the ipsilateral masking function, it was relatively modest. This is in sharp contrast to the results of normal hearing listeners where the magnitude of the contralateral masking function is greatly reduced. These results suggest that MOC function may not play a large role in the sharpness of the contralateral masking function but may play a considerable role in the magnitude of the contralateral masking function.  相似文献   

13.
The authors studied fused auditory image (FAI) movement trajectories under conditions of direct nonsimultaneous masking. This movement was created by a gradual change in a dichotically presented series of clicks with interaural differences in stimulation from 0 to ±700 s or from ±700 to 0 s. Binaurally presented transmissions of wide-band noise served as maskers. The location and length of the trajectories were evaluated without a masker and with five values of the time lag between the signal beginning and masker end. When the test signal duration was 200 ms, the length of the trajectories was 33–44° without a masker. In the first test group, this trajectory lay close to the median line of the head without a masker (irrespective of the movement direction) and moved away from it under masking conditions. When the FAI moved from the median line towards the right or left ear, the initial part of the trajectory was masked; when the movement direction was opposite, the final part was masked. In the second group, the trajectories were located near the ears when the FAI moved from either ear and shifted towards the median line as a result of masking. When the movement direction was opposite, they were close to the median line and shifted towards the ear under masking conditions. When the FAI moved along all trajectories, their initial parts were masked.  相似文献   

14.
Thresholds of the event-related potentials (ERPs) appearance were measured for one stationary and four moving auditory images presented in silence or under forward masking conditions. The difference between thresholds in silence and after noise masker was considered as masking level. Under the forward masking, the amplitude of the ERP to the first click in the test series decreased in guinea pig auditory cortex. Masking level decreased with the time lag between signal and masker and didn't depend on the fused auditory image localization that corresponded to the first click in different test signals. This fact can support the hypothesis that for the long test signals the initial part can be masked more than the final one. The ERPs amplitude to next clicks in test series depended on interaction of two factors: forward masking in the "masker-signal" system and interaction of separate ERPs in the series evoked by the test signal.  相似文献   

15.
It was recently shown that the cutaneous sensitivity to airpuffs is decreased by a low-frequency vibrotactile masker in the hairy skin, and by a low-frequency but especially by a high-frequency masker in the glabrous skin. In the current study, the spatial features of this masking effect were determined in four healthy human subjects, using a reaction time paradigm. The masking effect decreased monotonically with increasing interstimulus distance, and identically in longitudinal and transverse (i.e., lateral) directions in the palm or dorsal surface of the hand. The masking effect was stronger in the glabrous than in the hairy skin, especially in the fingers. In the glabrous skin, the spread of masking effect produced by a high-frequency masker was more extensive than that produced by a low-frequency masker. The mechanical spread of high-frequency vibration was less extensive than that of low-frequency vibration in the skin. In the glabrous skin, a masker applied to the tip of the finger produced a stronger masking effect on sensations in the base of the finger than when the masker was located at the base and the test stimulus was located at the tip. It is concluded that mechanical spread of vibration in the skin is of minor importance in explaining the masking effects. Different peripheral neural mechanisms underlie the airpuff-elicited sensations in the hairy and glabrous skin. The afferent inhibitory mechanisms are stronger for signals coming from the glabrous skin of the fingers than for signals coming from the hairy skin. Furthermore, the peripheral innervation density and size of the cortical representational areas may be of importance in determining the magnitude of the masking effect.  相似文献   

16.
自由声场条件下,以强度为神经元最小阈值阈上5dB,时程分别为40、60、80和100ms的纯音作为前掩蔽声,观察和记录了不同时程弱前掩蔽声对小鼠(Musmusculus Km)下丘神经元发放和声强处理的影响。实验记录到154个神经元,对其中的104个神经元做了不同时程掩蔽声影响的测试。结果发现:掩蔽声对神经元放电率的抑制作用在时间上表现为前抑制(41%)、后抑制(9%)和全抑制(50%)三种类型。改变掩蔽声时程时,大部分神经元(72%)的抑制类型不发生改变,但少部分神经元(28%)随掩蔽声时程的增加,大量的后抑制类型转变为前抑制或全抑制类型。此外,超过一半的神经元(58.06%)其强度.放电率函数曲线随掩蔽声时程的改变而发生转变,主要表现为单调型向饱和型转变及饱和型向非单调型转变,这种转变并不随掩蔽声时程增加表现出规律性的变化。结果表明,前掩蔽作用于下丘神经元声反应的时间域和强度域时具有不均衡性,推测不同时程弱前掩蔽声激活的抑制性输入能分化性调制下丘神经元声反应特性。  相似文献   

17.
The efferent innervation of guinea pig cochleas was sectioned medially, at the level of the floor of the fourth ventricle, to study the effects of the crossed part of the medial efferent pathway on the compound action potential (CAP) masking phenomenon. Sectioning reduced CAP masking for a masker level varying with the frequency of the masker and the time elapsed between the masker onset and the probe onset. Functional properties of the crossed part of the medial efferent tracts: latency, thresholds and frequency selectivity, could be deduced from these data. This intensification of the masking phenomenon permitting the improvement of the signal to noise ratio, may thus be attributed to the crossed part of the medial efferent bundle which innervates the outer hair cells.  相似文献   

18.
Previous studies in the inferior colliculus have shown that spatial separation of signal and noise sources improves signal detection. In this study, we investigated the free-field unmasking response properties of single fibers in the auditory nerve--these were compared to those of inferior colliculus neurons under the same experimental conditions to test the hypothesis that central processing confers advantages for signal detection in the presence of spatially separated noise. For each neuron, we determined the detection threshold for a probe at the unit's best azimuth under three conditions: (1) by itself, (2) when a masker at a constant level was also presented at the unit's best azimuth, and (3) when the masker was positioned at different azimuths. We found that, on average, maskers presented at a unit's best azimuth elevated the probe detection threshold by 4.22 dB in the auditory nerve and 10.97 dB in the inferior colliculus. Angular separation of probe and masker sources systematically reduced the masking effect. The maximum masking release was on average 2.90 dB for auditory nerve fibers and 9.40 dB for inferior colliculus units. These results support the working hypothesis, suggesting that central processing contributes to the stronger free-field unmasking in the inferior colliculus.  相似文献   

19.
Summary Two big brown bats (Eptesicus fuscus) were trained to report the presence or absence of a virtual sonar target. The bats' sensitivity to transient masking was investigated by adding 5 ms pulses of white noise delayed from 0 to 16 ms relative to the target echo. When signal and masker occurred simultaneously, the bats required a signal energy to noise spectrum level ratio of 35 dB for 50% probability of detection. When the masker was delayed by 2 ms or more there was no significant masking and echo energy could be reduced by 30 dB for the same probability of detection. The average duration of the most energetic sonar signal of each trial was measured to be 1.7 ms and 2.4 ms for the two bats, but a simple relation between detection performance and pulse duration was not found.In a different experiment the masking noise pulses coincided with the echo, and the duration of the masker was varied from 2 to 37.5 ms. The duration of the masker had little or no effect on the probability of detection.The findings are consistent with an aural integration time constant of about 2 ms, which is comparable to the duration of the cries. This is an order of magnitude less than found in backward masking experiments with humans and may be an adaptation to the special constraints of echolocation. The short time of sensitivity to masking may indicate that the broad band clicks of arctiid moths produced as a countermeasure to bat predation are unlikely to function by masking the echo of the moth.Abbreviations SPL sound pressure level - SD standard deviation - SE standard error - BW bandwidth  相似文献   

20.
It was recently shown that the cutaneous sensitivity to airpuffs is decreased by a low-frequency vibrotactile masker in the hairy skin, and by a low-frequency but especially by a high-frequency masker in the glabrous skin. In the current study, the spatial features of this masking effect were determined in four healthy human subjects, using a reaction time paradigm. The masking effect decreased monotonically with increasing interstimulus distance, and identically in longitudinal and transverse (i.e., lateral) directions in the palm or dorsal surface of the hand. The masking effect was stronger in the glabrous than in the hairy skin, especially in the fingers. In the glabrous skin, the spread of masking effect produced by a high-frequency masker was more extensive than that produced by a low-frequency masker. The mechanical spread of high-frequency vibration was less extensive than that of low-frequency vibration in the skin. In the glabrous skin, a masker applied to the tip of the finger produced a stronger masking effect on sensations in the base of the finger than when the masker was located at the base and the test stimulus was located at the tip. It is concluded that mechanical spread of vibration in the skin is of minor importance in explaining the masking effects. Different peripheral neural mechanisms underlie the airpuff-elicited sensations in the hairy and glabrous skin. The afferent inhibitory mechanisms are stronger for signals coming from the glabrous skin of the fingers than for signals coming from the hairy skin. Furthermore, the peripheral innervation density and size of the cortical representational areas may be of importance in determining the magnitude of the masking effect.  相似文献   

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