共查询到20条相似文献,搜索用时 15 毫秒
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Kozuka T Sugita M Shetzline S Gewirtz AM Nakata Y 《Journal of immunology (Baltimore, Md. : 1950)》2011,187(11):5974-5982
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Martin LJ Taniguchi H Robert NM Simard J Tremblay JJ Viger RS 《Molecular endocrinology (Baltimore, Md.)》2005,19(9):2358-2370
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The development of Th subset is accompanied by subset-specific chromatin remodeling of cytokine gene loci. In this study, we show that the C-terminal, but not the N-terminal zinc finger (N-finger) of GATA-3 mediates the association with the IL-4/IL-13 intergenic DNase I hypersensitive site and the induction of an extended DNase I hypersensitivity on the IL-4/IL-13 locus. Consistently, deletion of the transactivation domains or the C-finger, but not the N-finger, abrogated the induction of IL-4 and IL-13 as well as the down-regulation of IFN-gamma. In contrast, the N-finger of GATA-3 was indispensable for the binding to the IL-5 promoter and the induction of IL-5. The selective use of the N-finger may underlie the differential roles of GATA-3 in the induction of IL-4, IL-13, and IL-5. 相似文献
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Kishikawa H Sun J Choi A Miaw SC Ho IC 《Journal of immunology (Baltimore, Md. : 1950)》2001,167(8):4414-4420
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Dentice M Morisco C Vitale M Rossi G Fenzi G Salvatore D 《Molecular endocrinology (Baltimore, Md.)》2003,17(8):1508-1521
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Maneechotesuwan K Xin Y Ito K Jazrawi E Lee KY Usmani OS Barnes PJ Adcock IM 《Journal of immunology (Baltimore, Md. : 1950)》2007,178(4):2491-2498
GATA-3 plays a critical role in allergic diseases by regulating the release of cytokines from Th2 lymphocytes. However, the molecular mechanisms involved in the regulation of GATA-3 in human T lymphocytes are not yet understood. Using small interfering RNA to knock down GATA-3, we have demonstrated its critical role in regulating IL-4, IL-5, and IL-13 release from a human T cell line. Specific stimulation of T lymphocytes by costimulation of CD3 and CD28 to mimic activation by APCs induces translocation of GATA-3 from the cytoplasm to the nucleus, with binding to the promoter region of Th2 cytokine genes, as determined by chromatin immunoprecipitation. GATA-3 nuclear translocation is dependent on its phosphorylation on serine residues by p38 MAPK, which facilitates interaction with the nuclear transporter protein importin-alpha. This provides a means whereby allergen exposure leads to the expression of Th2 cytokines, and this novel mechanism may provide new approaches to treating allergic diseases. 相似文献
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