共查询到20条相似文献,搜索用时 6 毫秒
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Biros SM Moisan L Mann E Carella A Zhai D Reed JC Rebek J 《Bioorganic & medicinal chemistry letters》2007,17(16):4641-4645
The design and synthesis of alpha-helix peptidomimetics using inverse electron demand Diels-Alder reactions is described. The potency of the resulting pyridazine-based library to disrupt the Bak/Bcl-X(L) interaction was tested using an in vitro fluorescence polarization assay. 相似文献
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NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis 总被引:1,自引:0,他引:1
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Shin S Wakabayashi N Misra V Biswal S Lee GH Agoston ES Yamamoto M Kensler TW 《Molecular and cellular biology》2007,27(20):7188-7197
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Kumaraswamy Naidu Chitrala Xiaoming Yang Prakash Nagarkatti Mitzi Nagarkatti 《BMC structural biology》2018,18(1):15
Background
Aryl hydrocarbon receptor (AhR) ligands may act as potential carcinogens or anti-tumor agents. Understanding how some of the residues in AhR ligand binding domain (AhRLBD) modulate their interactions with ligands would be useful in assessing their divergent roles including toxic and beneficial effects. To this end, we have analysed the nature of AhRLBD interactions with 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD), 6-formylindolo[3,2-b]carbazole (FICZ), indole-3-carbinol (I3C) and its degradation product, 3,3′-diindolylmethane (DIM), Resveratrol (RES) and its analogue, Piceatannol (PTL) using molecular modeling approach followed by molecular dynamic simulations.Results
Results showed that each of the AhR ligands, TCDD, FICZ, I3C, DIM, RES and PTL affect the local and global conformations of AhRLBD.Conclusion
The data presented in this study provide a structural understanding of AhR with its ligands and set the basis for its functions in several pathways and their related diseases.11.
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Korkalainen M Tuomisto J Pohjanvirta R 《Biochemical and biophysical research communications》2000,273(1):272-281
Hamsters and Han/Wistar (Kuopio; H/W) rats show peculiarly selective responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). They are extremely resistant to its acute lethality but sensitive to, e.g. , enzyme induction. The biological effects of TCDD are mediated by the AH receptor (AHR). Recent studies on H/W rat AHR discovered a remodelled transactivation domain which appears to be critical for the TCDD resistance of these animals. Here, molecular cloning and sequencing of hamster AHR reveals another type of restructured transactivation domain. In hamsters, the functionally pivotal Q-rich region is substantially expanded and enriched in glutamine compared with all other AHRs cloned to date. By contrast, the amino-terminal end is highly conserved, which is in agreement with the H/W rat AHR. Because of the additional material in the transactivation domain, hamster AHR protein is larger than that in rats or mice, but the pattern of AHR mRNA expression in tissues is similar. 相似文献
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Soujanya D. Yelamanchi Hitendra Singh Solanki Aneesha Radhakrishnan Lavanya Balakrishnan Jayshree Advani Remya Raja Nandini A. Sahasrabuddhe Premendu Prakash Mathur Pinaki Dutta T. S. Keshava Prasad Aditi Chatterjee Harsha Gowda Kanchan Kumar Mukherjee 《Journal of cell communication and signaling》2016,10(4):341-346
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