Family physicians' attitudes toward advance directives.

OBJECTIVE: To examine the attitudes toward, the experience with and the knowledge of advance directives of family physicians in Ontario. DESIGN: Cross-sectional survey. PARTICIPANTS: A questionnaire was mailed to 1000 family physicians, representing a random sample of one-third of the active members of the Ontario College of Family Physicians; 643 (64%) responded. RESULTS: In all, 86% of the physicians favoured the use of advance directives, but only 19% had ever discussed them with more than 10 patients. Most of the physicians agreed with statements supporting the use of advance directives and disagreed with statements opposing their use. Of the respondents 80% reported that they had never used a directive in managing an incompetent patient. Of the physicians who responded that they had such experience, over half said that they had not always followed the directions contained in the directive. The proportions of physicians who responded that certain patient groups should be offered the opportunity to complete an advance directive were 96% for terminally ill patients, 95% for chronically ill patients, 85% for people with human immunodeficiency virus infection, 77% for people over 65 years of age, 43% for all adults, 40% for people admitted to hospital on an elective basis and 33% for people admitted on an emergency basis. The proportions of physicians who felt that the following strategies would encourage them to offer advance directives to their patients were 92% for public education, 90% for professional education, 89% for legislation protecting physicians against liability when following a directive, 80% for legislation supporting the use of directives, 79% for hospital policy supporting the use of directives, 73% for reimbursement for time spent discussing directives with patients and 64% for hospital policy requiring that all patients be routinely offered the opportunity to complete a directive at the time of admission. CONCLUSIONS: Family physicians favour advance directives but use them infrequently. Most physicians support offering them to terminally or chronically ill patients but not to all patients at the time of admission to hospital. Although governments emphasize legislation, most physicians believe that public and professional education programs would be at least as likely as legislation to encourage them to offer advance directives to their patients.     

广西龙胜红瑶传统药用植物的民族植物学知识

瑶族是一个拥有悠久历史和灿烂文化的民族,红瑶是其中一个分支,因妇女服饰上的花纹图案以大红色为主而得名,其生活习俗饱含民族特色,对植物尤其是药用植物的利用方式,与其他民族不同。该研究采用经典的民族植物学理论和方法,访问调查了广西龙胜红瑶传统药用植物种类,根据植物拉丁名、中文名、当地名、用途、用法及药用部位,对其进行民族植物学编目,并与《中国药典》作了比较。结果表明:共记录到药用植物95种,隶属于57科83属,其中蔷薇科、百合科种类最多,分别含有7种,显示龙胜红瑶传统药用植物资源的多样性;全株入药的植物种类41种,占总数的43.16%;根入药的种类为23种,占总数的24.21%;叶入药的种类为13种,占总数的13.68%。药用植物的药用部位以全株、根及叶为主;治疗风湿类疾病的药物比重最大,为23.47%,推测与其生活的环境有关;与《中国药典》比较,发现71种植物未被其收录,另有17种虽被收录但主治功效不同,有7种被收录且主治功效大致相同,为新型中药的研发提供了借鉴。同时,还探讨了龙胜红瑶传统药用植物的药用价值、资源现状及文化传承的问题。     

Health research funding: Members' of Parliament knowledge of and attitudes toward health research and funding

Background

Establishment of the Canadian Institutes of Health Research (CIHR) in 2000 resulted in increased funding for health research in Canada. Since 2001, the number of proposals submitted to CIHR that, following peer review, are judged to be of scientific merit to warrant funding, has grown by 77%. But many of these proposals do not receive funding because of budget constraints. Given the role of Members of Parliament in setting government funding priorities, we surveyed Members of Parliament about their knowledge of and attitudes toward health research, health research funding and CIHR.

Methods

All Members of Parliament were invited to participate, or to designate a senior aide to participate, in a 15-minute survey of knowledge of and attitudes toward health research, health research funding and CIHR. Interviews were conducted between July 15, 2006, and Dec. 20, 2006. Responses were analyzed by party affiliation, region and years of service as a Member of Parliament.

Results

A total of 101 of 308 Members of Parliament or their designated senior aides participated in the survey. Almost one-third of respondents were senior aides. Most of the respondents (84%) were aware of CIHR, but 32% knew nothing about its role. Participants believed that health research is a critical component of a strong health care system and that it is underfunded. Overall, 78% felt that the percentage of total government spending directed to health research funding was too low; 85% felt the same way about the percentage of government health care spending directed to health research. Fifty-four percent believed that the federal government should provide both funding and guidelines for health research, and 66% believed that the business sector should be the primary source of health research funding. Participants (57%) most frequently defined health research as study into cures or treatments of disease, and 22% of participants were aware that CIHR is the main federal government funding organization for health research. Participants perceived health research to be a low priority for Canadian voters (mean ranking 3.8/10, with 1 being unimportant and 10 being extremely important [SD 1.85]).

Interpretation

Our results highlight significant knowledge gaps among Members of Parliament regarding health research. Many of these knowledge gaps will need to be addressed if health research is to become a priority.Over the past 8 years, health research has been an important but declining priority for the federal government. The development of the Canada Foundation for Innovation, the Canada Research Chairs, Genome Canada, the Networks of Centres of Excellence, the Canadian Health Services Foundation and the Canadian Institutes of Health Research (CIHR)¹ reflects this initial interest. Although most of these programs receive multi-year funding, CIHR receives annual funding from the federal government. However, its annual increases have not risen proportionately with the number of requests for funding it receives each year.CIHR is the federal funding body for health research and consists of 13 institutes. It supports 4 pillars of research: biomedical research, clinical research, social and cultural aspects of health and population health research, and health services and systems research. With the formation of CIHR,² federal funding for health research increased from $289 million in 2000 to $553 million in 2002, with subsequent 5%–6% annual increases until 2006. That year, the increase was 2.4%.³ The initial increases in funding stimulated a sharp rise in the number of grants submitted and funded annually. In the 2006 competition, the increase in funding was lower than expected and the success rate in the open competition fell to 16% from the mean rate of 31.7% in previous years. As a result, 60% of peer-reviewed grants rated as very good or excellent were not funded, as compared with 38% in 2001 (CIHR: unpublished data,2007).Because Members of Parliament vote annually to determine CIHR''s budget for funding health research, we surveyed Members of Parliament and their senior aides about their knowledge of and attitudes toward health research, health research funding and CIHR.     

Consensus of the 'Malasars' traditional aboriginal knowledge of medicinal plants in the Velliangiri holy hills, India

Dusky grouper (garoupa, Epinephelus marginatus) is an important catch for several artisanal small-scale fisheries along the Brazilian coast. It is a sedentary, monandric, and late maturing protogynous species, which makes it vulnerable to overharvesting even though it is mainly caught through hook and line or spear fishing through free diving. Lack of information on the ecology and biology of this species in Brazil is astonishing. Much of the information found in the literature concerns Mediterranean dusky groupers. Studies compiling local knowledge (ethnoecology) about fish species complement biological data, and have been fundamental for effective fisheries management. In this study, our objectives are to obtain data about dusky grouper through fish catches and analysis of stomach contents and gonad maturation (macroscopic analyses), along with interviews from fishermen from six small-scales communities from the southern (Pântano do Sul, Florianópolis, Santa Catarina State) to the northern Brazilian coast (Porto Sauípe, Bahia State). We conclude that precautionary approaches and 'data-less' management approaches are needed in the coast of Brazil. Research on this species and on the potential of aquaculture for its cultivation, are urgent, due to the apparent vulnerability and decrease of dusky grouper along the coast of Brazil.     

Correlates of attitudes toward euthanasia

Abstract

Data from a national survey conducted in 1977 were examined to identify correlates of attitudes toward euthanasia and suicide for terminally ill persons. The results indicated that race, religious participation, and attitudes toward freedom of expression were directly associated with such attitudes. It was also found that regional variations in such attitudes could be explained by the degree of urbanization of geographic regions.     

Antineoplastic potential of medicinal plants

Cancer is one of the most dreaded diseases worldwide and the incidence is on the rise in both developing and developed countries. It is treated by chemotherapy, radiotherapy and surgery. In spite of advances in treatment strategies, cancer still remains a major cause of death. Research is on for development of better drugs which are more effective and simultaneously cause fewer side effects. Plants have been used for the treatment of various ailments of man and animals since ages. They are being screened extensively to explore the possibility of development of economically viable anticancer drugs. Natural products of plant origin currently constitute a considerable proportion of commercially available antineoplastic drugs. This review gives an insight into commercially available anticancer drugs of plant origin and also patents granted to plant derived components, extracts and polyherbal formulations possessing anticancer activity. The exhaustive work reviewed here on antineoplastic activity of various plants both in vitro and experimental models throughout the world will help design further research in this field.     

Endophytic actinobacteria of medicinal plants: diversity and bioactivity

Endophytes are the microorganisms that exist inside the plant tissues without having any negative impact on the host plant. Medicinal plants constitute the huge diversity of endophytic actinobacteria of economical importance. These microbes have huge potential to synthesis of numerous novel compounds that can be exploited in pharmaceutical, agricultural and other industries. It is of prime importance to focus the present research on practical utilization of this microbial group in order to find out the solutions to the problems related to health, environment and agriculture. An extensive characterization of diverse population of endophytic actinobacteria associated with medicinal plants can provide a greater insight into the plant-endophyte interactions and evolution of mutualism. In the present review, we have discussed the diversity of endophytic actinobacteria of from medicinal plants their multiple bioactivities.     

Traditional knowledge of wild medicinal plants used by the inhabitants of Garam Chashma valley,district Chitral,Pakistan

Garam Chashma valley is a mountainous valley situated in the Hindukush mountain range in Pakistan. This area is blessed with rich and diverse medicinal flora extensively utilized by the local community to cure health issues. The present article aims to explore and document the indigenous traditional knowledge about wild plants and their curative properties. This survey was carried out during April 2018 to September 2019. Data was collected from 153 indigenous people through semi structure questionnaire, group discussion, field survey and formal talks with elder people. Quantitative analysis of recorded data was obtained by applying quantitative indices like Frequency of Citation (FC) Use Reports (UR), Family Use Value (FUV), Informant Consensus Factor (ICF), Use Value (UV) and Relative Frequency of Citation (RFC). About 83 plant taxa belonging to 36 different families were recorded for the treatment of 95 different disorders grouped into sixteen disease categories. Herbs were the most leading plant habit (81.9%) and dried plant material (51.8%) usually preferred for therapeutics uses. Among families Asteraceae (16.86%) was recorded as major taxon with highest number of species followed by Lamiaceae (12.06%). Leaves 33% were recorded most abundantly used plant part followed by flowers (17%). Regarding to formulations, decoction (39.3%) and powder (17.1%) were recorded most frequent mode of preparation while oral intake (78%) was most preferred administration route. About (40%) plants species were utilized to treat Gastrointestinal diseases (GIT) disorders. Informant consensus revealed that Gastrointestinal disorders and Dermatological disorders were top ranked ailments categories with 0.94 consensus. The current study imparted that medicinal plants are still used by the indigenous communities of Garam Chashma valley, district lower Chitral, Pakistan. Thus, this investigation provides basis for the conservation of medicinal flora in the area. Medicinal plants (MPs) having high value of FC, RFC, UV, FUV, FL and ICF should be further study for phytochemistry and ethnopharmacology to evaluate novel active ingredients for new drugs discovery.     

Indigenous oral knowledge of wild medicinal plants from the Peren district of Nagaland,India in the Indo Burma hot-spot

The paper report the oral traditional knowledge of wild medicinal plants usage by the indigenous ethnic tribal community from the Peren district of Nagaland, India in the Indo-Burma Hotspot. The pioneer study was based on the semi-structured interview of locals (N = 240) in the 12 villages of the Peren District during 2014 ‐ 2018. In total, 179 ethnomedicinal plants from 140 genera and 72 families were documented and identified. The medicinal plants were used for the treatment of 96 different ailments grouped into 18 categories. The medicinal plants also showed high versatile nature with 85 species reported to treat five / eleven different ailments, respectively. The ethnobotanical information obtained from the field documentation will contribute in the development of potential drugs in the future from the diverse wild medicinal plants of the region and contribute towards the preservation of the oral tradition that is disappearing.     

Towards the scientific validation of traditional medicinal plants

A large proportion of the population of developing countries usestraditional medicine alone, or in combination with Western drugs to treat awide variety of ailments. There has seldom been effective collaborationbetween the traditional and Western medical practitioners, largely due tothe perception that the use of traditional and herbal medicines has noscientific basis. With the renewed interest from Western countries in herbalremedies, and the increasingly urgent need to develop new effective drugs,traditionally used medicinal plants have recently received the attention ofthe pharmaceutical and scientific communities. This involves the isolationand identification of the secondary metabolites produced by the plants andused as the active principles in medical preparations. Research into thescientific validation of southern African medicinal plants used in thetreatment of pain and inflammation, hypertension and parasitic diseasesincluding those with anthelmintic, anti-amoebic, anti-bacterial and anti-bilharzia activity, is the current focus of studies conducted at the ResearchCentre for Plant Growth and Development.     

Antiviral potential of Bulgarian medicinal plants

Medicinal plants have been widely used to treat a variety of infectious and non-infectious diseases. Bulgarian flora includes 4,300 plant species, over 500 of which are rare or endemic to the country or the Balkan region. The aim of the present work is to summarize comprehensively the investigations on the antiviral activity of Bulgarian medicinal plants from the past three decades. The effect of different extracts derived from in vitro propagated plants has been examined as well. The phytochemical composition and its influence on specific steps of the viral life cycle have been discussed in this paper. The review includes the following families: Amaryllidaceae, Fabaceae, Geraniaceae, Lamiaceae, Onagraceae, Ranunculaceae, Rosaceae, Scrophulariaceae and Rhodophyta. Special attention has been paid to viruses as important human pathogens.     

Forms of silicon in medicinal plants

The contents of three forms of silicon (organic, soluble mineral, and polymeric) were determined in leaves of 21 medicinal plants. At a total content of silicon 0.74 to 3.59% the organic, soluble mineral, and polymeric forms accounted for 0.51-1.91%, 0.05-0.51%, and 0.1-1.21%, respectively. An analysis of silicon in the condensed polyphenol fraction was performed for the first time revealing the presence of a covalently bound form in the amounts of 0.1 to 0.2% of the total silicon content in the leaves. These results are of interest for food or medical applications of the plants studied.     

药用木本植物的生态保护

在分析我国药用木本植物的利用现状和特殊性的基础上。揭示了药用木本植物保护与利用之间的矛盾。提出了解决矛盾的根本出路和需要开展的基础研究工作．研究成树主要药用成分的器官分布、季节变化、年龄差异以及与环境因素的相关性;研究幼树主要药用成分的器官分布、季节变化特别是年龄差异;研究环境因素(培育条件)对幼树主要药用成分的影响和调控规律;进一步从蛋白质(主要药用成分代谢过程中的关键酶)和核酸(关键酶的编码基因)水平解析环境因子对幼树主要药用成分的调控机理．     

Biological screening of Brazilian medicinal plants

In this study, we screened sixty medicinal plant species from the Brazilian savanna ("cerrado") that could contain useful compounds for the control of tropical diseases. The plant selection was based on existing ethnobotanic information and interviews with local healers. Plant extracts were screened for: (a) molluscicidal activity against Biomphalaria glabrata, (b) toxicity to brine shrimp (Artemia salina L.), (c) antifungal activity in the bioautographic assay with Cladosporium sphaerospermum and (d) antibacterial activity in the agar diffusion assay against Staphylococcus aureus, Escherichia coli, Bacillus cereus and Pseudomonas aeruginosa. Forty-two species afforded extracts that showed some degree of activity in one or more of these bioassays.     

黄酮类化合物在药用植物中的分布

将蕨类植物、裸子植物、被子植物的32个科的50种植物所含的黄酮类化合物列举出来,可以作为进一步开发药用价值以及进行植物分类的依据。