共查询到20条相似文献,搜索用时 15 毫秒
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Kerstin Hasenpusch-Theil Brian P. Chadwick Thomas Theil Stephanie K. Heath David G. Wilkinson Anna-Marie Frischauf 《Mammalian genome》1999,10(3):294-298
We have isolated and characterized a novel PHD finger gene, PHF2, which maps to human Chromosome (Chr) 9q22 close to D9S196.
Its mouse homolog was also characterized and mapped to the syntenic region on mouse Chr 13. The predicted human and mouse
proteins are 98% identical and contain a PHD finger domain, eight possible nuclear localization signals, two potential PEST
sequences, and a novel conserved hydrophobic domain. Northern analysis shows widespread expression of PHF2 in adult tissues,
while in situ hybridization on mouse embryos reveals staining in the neural tube and dorsal root ganglia significantly above
a ubiquitous low level expression signal. From its expression pattern and its chromosomal localization, PHF2 is a candidate
gene for hereditary sensory neuropathy type I, HSN1.
Received: 9 July 1998 / Accepted: 16 October 1998 相似文献
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Aapola U Kawasaki K Scott HS Ollila J Vihinen M Heino M Shintani A Kawasaki K Minoshima S Krohn K Antonarakis SE Shimizu N Kudoh J Peterson P 《Genomics》2000,65(3):293-298
We have isolated the DNMT3L gene that is related to the cytosine-5-methyltransferase 3 (DNMT3) family. The gene is located on chromosome 21q22.3 between the AIRE and the KIAA0653 genes and spans approximately 16 kb of genomic sequence. The encoded protein of 387 amino acids has a cysteine-rich region containing a novel-type zinc finger domain that is conserved in DNMT3A and DNMT3B but also in ATRX, a member of the SNF2 protein family. The novel domain, called an ADD (ATRX, DNMT3, DNMT3L)-type zinc finger, contains two subparts: a C2C2 and an imperfect PHD zinc finger. Expression of the DNMT3L mRNA was not detectable by Northern blotting; however, RT-PCR amplification revealed that it is expressed at low levels in several tissues including testis, ovary, and thymus. 相似文献
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A novel family of bromodomain genes 总被引:8,自引:0,他引:8
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Ulla Aapola Kazunori Shibuya Hamish S. Scott Juha Ollila Mauno Vihinen Maarit Heino Ai Shintani Kazuhiko Kawasaki Shinsei Minoshima Kai Krohn Stylianos E. Antonarakis Nobuyoshi Shimizu Jun Kudoh Prt Peterson 《Genomics》2000,65(3):293
We have isolated the DNMT3L gene that is related to the cytosine-5-methyltransferase 3 (DNMT3) family. The gene is located on chromosome 21q22.3 between the AIRE and the KIAA0653 genes and spans approximately 16 kb of genomic sequence. The encoded protein of 387 amino acids has a cysteine-rich region containing a novel-type zinc finger domain that is conserved in DNMT3A and DNMT3B but also in ATRX, a member of the SNF2 protein family. The novel domain, called an ADD (ATRX, DNMT3, DNMT3L)-type zinc finger, contains two subparts: a C2C2 and an imperfect PHD zinc finger. Expression of the DNMT3L mRNA was not detectable by Northern blotting; however, RT-PCR amplification revealed that it is expressed at low levels in several tissues including testis, ovary, and thymus. 相似文献
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