共查询到20条相似文献,搜索用时 15 毫秒
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Linder MR Heckeroth AR Najdrowski M Daugschies A Schollmeyer D Miculka C 《Bioorganic & medicinal chemistry letters》2007,17(15):4140-4143
The trans-enantiomers of the commercially important anti-protozoal compound Halofuginone have been prepared and characterized, and the absolute configuration was assigned by X-ray crystallography. The activity of both enantiomers against Cryptosporidium parvum was determined in vitro and related to acute toxicity in vivo. It was shown that both the activity and the toxicity are properties of the (2R,3S)-enantiomer. We conclude that with respect to broadening the therapeutic window there is no advantage in application of one enantiomer over the application of the racemic mixture in the treatment of C. parvum infections. 相似文献
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E Marani J W van Oers P A Tetteroo R E Poelmann J van der Veeken M G Deenen 《Acta morphologica Neerlando-Scandinavica》1986,24(2):103-110
Immunodetections of carbohydrate surface antigens were carried out for SSEA-1 and SSEA-3. Using alkaline phosphatase for the detection of primordial germ cells these surface antigens were detected at the cell membrane and the cytoplasm of the germ cells at E 10. 相似文献
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Y L Qiu A Hempel N Camerman A Camerman F Geiser R G Ptak J M Breitenbach T Kira L Li E Gullen Y C Cheng J C Drach J Zemlicka 《Nucleosides & nucleotides》1999,18(4-5):597-598
Synthesis, absolute configuration and antiviral activity of enantiomeric antiviral agents (R)-(-)- and (S)-(+)-synadenol (2 and 3a) are described. 相似文献
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