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复发性外阴阴道念珠菌病是一种由念珠菌机会感染引起的皮肤黏膜疾病,其发病机制复杂,而念珠菌的侵袭与宿主诱发因素是复发性外阴阴道念珠菌病的主要致病因素。其中,念珠菌可通过多种方式攻击宿主细胞和逃避宿主免疫系统而导致机体损伤。Nrf2信号通路是细胞抗氧化的主要调控机构,同时也是一种重要的免疫调节机构。一方面,Nrf2通路可下调NF-κB通路和促进Th17、Treg、Th1细胞的活化,启动宿主适应性免疫;同时,Nrf2通路可激活树突状细胞介导机体固有免疫。另一方面,Nrf2通路还可通过抗氧化应激损伤来阻止阴道炎的发展。该文对Nrf2通路在复发性念珠菌性阴道炎发病机制中的抗氧化应激和免疫调节作用进行综述,旨在研究Nrf2信号通路与复发性外阴阴道念珠菌病发病机制间的关系,从而指导临床治疗复发性外阴阴道念珠菌病。 相似文献
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《中国真菌学杂志》2017,(4)
复发性外阴阴道念珠菌病是一种由念珠菌机会感染引起的皮肤黏膜疾病,其发病机制复杂,而念珠菌的侵袭与宿主诱发因素是复发性外阴阴道念珠菌病的主要致病因素。其中,念珠菌可通过多种方式攻击宿主细胞和逃避宿主免疫系统而导致机体损伤。Nrf2信号通路是细胞抗氧化的主要调控机构,同时也是一种重要的免疫调节机构。一方面,Nrf2通路可下调NF-κB通路和促进Th17、Treg、Th1细胞的活化,启动宿主适应性免疫;同时,Nrf2通路可激活树突状细胞介导机体固有免疫。另一方面,Nrf2通路还可通过抗氧化应激损伤来阻止阴道炎的发展。该文对Nrf2通路在复发性念珠菌性阴道炎发病机制中的抗氧化应激和免疫调节作用进行综述,旨在研究Nrf2信号通路与复发性外阴阴道念珠菌病发病机制间的关系,从而指导临床治疗复发性外阴阴道念珠菌病。 相似文献
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白念珠菌是人类正常菌群,也是致死性真菌感染最重要的病原体之一。目前,白念珠菌致病的决定性机制仍未明确,其对宿主的致病性主要取决于菌体的毒力因子、菌体与宿主相互作用两方面。能量代谢是白念珠菌生长繁殖的基础,也是影响其致病性的重要因素。深入研究白念珠菌能量代谢特征,探索其在致病过程中的作用,或可为发现新的药物靶点奠定基础。白念珠菌是人类正常菌群,也是致死性真菌感染最重要的病原体之一。目前,白念珠菌致病的决定性机制仍未明确,其对宿主的致病性主要取决于菌体的毒力因子、菌体与宿主相互作用两方面。能量代谢是白念珠菌生长繁殖的基础,也是影响其致病性的重要因素。深入研究白念珠菌能量代谢特征,探索其在致病过程中的作用,或可为发现新的药物靶点奠定基础。 相似文献
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《中国真菌学杂志》2020,(3)
白念珠菌是一种寄生于人类黏膜表面的条件致病菌,是导致免疫功能低下人群侵袭性真菌感染的主要病原菌。白念珠菌形成侵袭性感染的过程主要分为黏附、侵袭、播散、形成感染灶等步骤,其中黏附和侵袭过程最为关键。黏附是白念珠菌入侵宿主的前提,该过程主要依赖于细胞壁表面的黏附素。侵袭阶段主要与菌丝形成、细胞壁表面毒力蛋白表达和蛋白水解酶分泌增加有关。形成菌丝是白念珠菌侵袭宿主的关键因素,主要由细胞内cAMP/PKA和MAPK等信号通路调控;侵袭素主要位于白念珠菌细胞壁表面,可以协助其穿刺宿主上皮细胞、诱导内吞作用;白念珠菌还可分泌多种蛋白水解酶,它能够破坏宿主组织细胞,协助白念珠菌形成感染灶。该文主要对白念珠菌黏附和侵袭宿主过程中关键的毒力因子进行综述,为理解白念珠菌致病机制以及选择潜在的药物靶点提供参考。 相似文献
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H. Valdimarsson Janet M. Higgs R.S. Wells M. Yamamura J.R. Hobbs P.J.L. Holt 《Cellular immunology》1973,6(3):348-361
Twenty six patients with chronic mucocutaneous candidiasis (CMCC) have been studied. Four immunological patterns emerged.Five patients failed to produce migration inhibitory factor (MIF) in vitro although their lymphocytes were normally activated to DNA synthesis after challenge with candida antigen. Four of these patients were unable to mount delayed hypersensitivity (DH) reactions to candida antigen (CAg), purified protein derivative (PPD), or dinitrochlorobenzene (DNCB). The lack of DH in these patients is thought to reflect their inability to produce MIF.Another group of nine patients with absent DH to candida also failed to produce MIF after challenge with candida antigen. Their lymphocytes were, however, not activated in vitro by this antigen probably due to a factor present in their serum, which specifically inhibited candida induced transformation of lymphocytes from healthy individuals.Two patients were able to produce MIF in vitro but they were unable, nevertheless, to mount DH reactions. Furthermore, they did not show delayed inflammatory response to intradermal injections of a MIF preparation. It is postulated that these patients have defective macrophage function.In 10 patients no significant abnormalities in cellular or humoral immunity were revealed.It is concluded that chronic mucocutaneous candidiasis is a syndrome associated with several distinct immunological abnormalities. The pathogenesis of the syndrome is discussed and it is emphasized that chronic mucocutaneous candidiasis is a model which can be used for advancing our knowledge of the immune system. 相似文献
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Randall M. Goldblum Ralph A. Lord Elton Dupree Arthur G. Weinberg Armond S. Goldman 《Cellular immunology》1973,9(2):297-305
A 5-month-old male with an X-linked combined immunodeficiency was treated with transfer factor. Consequently, lymphocyte stimulation to phytohemagglutinin and Candida as well as delayed hypersensitivity to candida and 2,4-dinitrochlorobenzene developed and persisted for 4 weeks. When cellular immunity diminished, the patient succumbed to Pneumocystis carinii and cytomegalovirus infections. Because of the transfer of cellular immunity in this case, further trials of transfer factor are indicated when histocompatible bone marrow is not available for patients with combined immunodeficiency. 相似文献
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Pence BD Lowder TW Keylock KT Vieira Potter VJ Cook MD McAuley E Woods JA 《PloS one》2012,7(5):e36403
Research has shown that aging is associated with increased systemic inflammation as well as a reduction in the strength of immune responses. However, little evidence exists linking the decrease in cell-mediated immunity in older adults with other health parameters. We sought to examine the relationship between cell-mediated immunity as measured in vivo by the delayed-type hypersensitivity (DTH) response to candida antigen and demographic and physiological variables in older (65-80 y.o.) adults. Candida antigen response was not related to gender or obesity, or to a number of other physiological variables including fitness and body composition. However, positive responders had significantly lower serum C-reactive protein levels (CRP, p<0.05) vs. non-responders. Furthermore, subjects with CRP<4.75 mg?L(-1) had greater odds of developing a positive response compared to those with CRP>4.75 mg?L(-1). Therefore, positive responses to candida antigen in older adults appears to be related to lower levels of systemic inflammation. 相似文献
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Plasmodium falciparum malaria causes 500 million clinical cases with approximately one million deaths each year. After many years of exposure, individuals living in endemic areas develop a form of clinical immunity to disease known as premunition, which is characterised by low parasite burdens rather than sterilising immunity. The reason why malaria parasites persist under a state of premunition is unknown but it has been suggested that suppression of protective immunity might be a mechanism leading to parasite persistence. Although acquired immunity limits the clinical impact of infection and provides protection against parasite replication, experimental evidence indicates that cell-mediated immune responses also result in detrimental inflammation and contribute to the aetiology of severe disease. Thus, an appropriate regulatory balance between protective immune responses and immune-mediated pathology is required for a favourable outcome of infection. As natural regulatory T (Treg) cells are identified as an immunosuppressive lineage able to modulate the magnitude of effector responses, several studies have investigated whether this cell population plays a role in balancing protective immunity and pathogenesis during malaria. The main findings to date are summarised in this review and the implication for the induction of pathogenesis and immunity to malaria is discussed. 相似文献
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Borhan MH Gunn N Cooper A Gulden S Tör M Rimmer SR Holub EB 《Molecular plant-microbe interactions : MPMI》2008,21(6):757-768
White blister rust in the Brassicaceae is emerging as a superb model for exploring how plant biodiversity has channeled speciation of biotrophic parasites. The causal agents of white rust across a wide breadth of cruciferous hosts currently are named as variants of a single oomycete species, Albugo candida. The most notable examples include a major group of physiological races that each are economically destructive in a different vegetable or oilseed crop of Brassica juncea (A. candida race 2), B. rapa (race 7), or B. oleracea (race 9); or parasitic on wild crucifers such as Capsella bursa-pastoris (race 4). Arabidopsis thaliana is innately immune to these races of A. candida under natural conditions; however, it commonly hosts its own molecularly distinct subspecies of A. candida (A. candida subsp. arabidopsis). In the laboratory, we have identified several accessions of Arabidopsis thaliana (e.g.,. Ws-3) that can permit varying degrees of rust development following inoculation with A. candida races 2, 4, and 7, whereas race 9 is universally incompatible in Arabidopsis thaliana and nonrusting resistance is the most prevalent outcome of interactions with the other races. Subtle variation in resistance phenotypes is evident, observed initially with an isolate of A. candida race 4, indicating additional genetic variation. Therefore, we used the race 4 isolate for map-based cloning of the first of many expected white rust resistance (WRR) genes. This gene was designated WRR4 and encodes a cytoplasmic toll-interleukin receptor-like nucleotide-binding leucine-rich repeat receptor-like protein that confers a dominant, broad-spectrum white rust resistance in the Arabidopsis thaliana accession Columbia to representative isolates of A. candida races 2, 4, 7, and 9, as verified by transgenic expression of the Columbia allele in Ws-3. The WRR4 protein requires functional expression of the lipase-like protein EDS1 but not the paralogous protein PAD4, and confers full immunity that masks an underlying nonhypersensitive incompatibility in Columbia to A. candida race 4. This residual incompatibility is independent of functional EDS1. 相似文献
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RNA干扰(RNAi)是真核生物体内重要的基因表达调控方式之一.RNAi的一种原始的作用是帮助生物体抵抗病毒,早期的研究表明无脊椎动物可以利用RNAi抵抗病毒,但是哺乳动物是否存在这一机制一直存在争议.最新的研究发现了哺乳动物RNAi抗病毒的强有力的证据,并且研究人员认为,这是一种之前被忽视的、全新的免疫途径.值得注意... 相似文献
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Children with kwashiorkor showed a high incidence of deranged cellular immunity as evidenced by impairment of delayed cutaneous hypersensitivity reactions to candida and diphtheria toxoid antigens and of lymphocyte transformation after phytohaemagglutinin stimulation. This may contribute to their susceptibility to infection. A correlation was shown between the degree of impairment of tests of cellular immunity and the severity of the kwashiorkor. Once recovery was initiated the skin tests gave the expected positive results and the lymphocyte transformation index improved. Protein deprivation may result in impaired deoxyribonucleic acid (DNA) synthesis and in atrophy of both the thymus and the lymphoid tissue. 相似文献
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干旱胁迫对坡柳等抗旱树种幼苗膜脂过氧化及保护酶活性的影响 总被引:26,自引:7,他引:19
以金沙江干热河谷主要树种坡柳、银合欢、山毛豆实生幼苗为材料,通过盆栽苗自然干旱胁迫,同时以浇水处理为对照,研究了干旱胁迫对坡柳、银合欢、山毛豆3个树种丙二醛含量、膜相对透性及保护酶活性的影响。结果表明,干旱胁迫下3个树种幼苗的细胞膜透性、MDA及SOD, POD酶活性都发生了变化,只是变化的幅度和进程不同。干旱胁迫对银合欢膜系统损伤生成的主要降解产物不是MDA;山毛豆清除活性氧毒害作用主要不是通过SOD和POD的作用;通过叶片相对保水力测定及膜透性、MDA相对含量、酶活性变化情况的分析,3个树种中坡柳耐旱性最强,其次为银合欢,山毛豆居后。 相似文献
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乳杆菌对外阴道白假丝酵母菌病治疗的分子机制 总被引:2,自引:0,他引:2
目的通过应用乳杆菌代谢产物提取物治疗外阴道白假丝酵母菌的效果,探讨乳杆菌治疗白假丝酵母菌病的可能分子机制。方法选择符合外阴道白假丝酵母菌病患者57例,随机分为2组,组应用乳杆菌代谢产物提取物治疗7d(试验组);另一组采用常规治疗(对照组),观察治疗前后阴道pH的变化,白假丝酵母菌、乳杆菌的变化及临床治疗效果的变化。结果采用乳杆菌代谢产物提取物治疗后阴道pH值恢复正常,白假丝酵母菌降低,乳杆菌变化不明显,临床治疗效果明显。结论乳杆菌治疗白假丝酵母菌病的分子机制可能是乳杆菌持续产生的乙酸、9-十六碳烯酸、十六烷酸、9,12-十八碳二烯酸和9-十八碳烯酸作用的结果。 相似文献