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Nucleosomes inhibit both transcriptional initiation and elongation by RNA polymerase III in vitro. 总被引:1,自引:0,他引:1 下载免费PDF全文
R H Morse 《The EMBO journal》1989,8(8):2343-2351
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《Molecular cell》2023,83(15):2641-2652.e7
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RNA polymerase III transcription 总被引:2,自引:0,他引:2
A P Wolffe 《Current opinion in cell biology》1991,3(3):461-466
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The RNA polymerase III transcription apparatus. 总被引:19,自引:0,他引:19
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We previously reported that RNA polymerase II (purified from wheat germ) is inhibited by selenotrisulfides, the products of the reaction of selenite with sulfhydryl compounds [Frenkel, Walcott, and Middleton, Molecular Pharmacology 31, 112 (1987)]. We have now found that the initiation stage of the reaction is inhibited by selenotrisulfide but the elongation stage of the reaction is not. The actual start of the RNA chain is not inhibited by the selenotrisulfide, but rather the formation of the enzyme-DNA binary complex. Selenotrisulfide has a similar differential effect on initiation and elongation by RNA polymerase II from HeLa cells; in contrast, with E. coli RNA polymerase, it inhibits elongation as well. 相似文献