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Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine 总被引:1,自引:0,他引:1
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Brehm JH Koontz D Meteer JD Pathak V Sluis-Cremer N Mellors JW 《Journal of virology》2007,81(15):7852-7859
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Transmitted human immunodeficiency virus type 1 carrying the D67N or K219Q/E mutation evolves rapidly to zidovudine resistance in vitro and shows a high replicative fitness in the presence of zidovudine
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García-Lerma JG MacInnes H Bennett D Weinstock H Heneine W 《Journal of virology》2004,78(14):7545-7552
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Kisic M Matamoros T Nevot M Mendieta J Martinez-Picado J Martínez MA Menéndez-Arias L 《The Journal of biological chemistry》2011,286(23):20615-20624
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Relative replication fitness of a high-level 3'-azido-3'-deoxythymidine-resistant variant of human immunodeficiency virus type 1 possessing an amino acid deletion at codon 67 and a novel substitution (Thr-->Gly) at codon 69
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Imamichi T Berg SC Imamichi H Lopez JC Metcalf JA Falloon J Lane HC 《Journal of virology》2000,74(23):10958-10964
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Involvement of novel human immunodeficiency virus type 1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitors 总被引:4,自引:0,他引:4
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Svicher V Sing T Santoro MM Forbici F Rodríguez-Barrios F Bertoli A Beerenwinkel N Bellocchi MC Gago F d'Arminio Monforte A Antinori A Lengauer T Ceccherini-Silberstein F Perno CF 《Journal of virology》2006,80(14):7186-7198
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Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215 总被引:6,自引:0,他引:6
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Chamberlain PP Ren J Nichols CE Douglas L Lennerstrand J Larder BA Stuart DI Stammers DK 《Journal of virology》2002,76(19):10015-10019
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Rodrigo D. Cunha Celina M. Abreu Luis M. F. Gonzalez Monique Nijhuis Dorien de Jong Renato S. Aguiar Adriana O. Afonso Rodrigo M. Brindeiro Amilcar Tanuri 《PloS one》2012,7(10)
Background
HIV-1 subtype B is the most prevalent in developed countries and, consequently, it has been extensively studied. On the other hand, subtype C is the most prevalent worldwide and therefore is a reasonable target for future studies. Here we evaluate the acquisition of resistance and the viability of HIV-1 subtype B and C RT clones from different isolates that were subjected to in vitro selection pressure with zidovudine (ZDV) and lamivudine (3TC).Methods/Principal Findings
MT4 cells were infected with chimeric virus pseudotyped with RT from subtype B and C clones, which were previously subjected to serial passage with increasing concentrations of ZDV and 3TC. The samples collected after each passage were analyzed for the presence of resistance mutations and VL. No differences were found between subtypes B and C in viral load and resistance mutations when these viruses were selected with 3TC. However, the route of mutations and the time to rebound of subtype B and C virus were different when subjected to ZDV treatment. In order to confirm the role of the mutations detected, other clones were generated and subjected to in vitro selection. RT subtype B virus isolates tended to acquire different ZDV resistance mutations (Q151M and D67N or T215Y, D67D/N and F214L) compared to subtype C (D67N, K70R, T215I or T215F).Conclusions/Significance
This study suggests that different subtypes have a tendency to react differently to antiretroviral drug selection in vitro. Consequently, the acquisition of resistance in patients undergoing antiretroviral therapy can be dependent on the subtypes composing the viral population. 相似文献17.
Increased multinucleoside drug resistance and decreased replicative capacity of a human immunodeficiency virus type 1 variant with an 8-amino-Acid insert in the reverse transcriptase
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van der Hoek L Back N Jebbink MF de Ronde A Bakker M Jurriaans S Reiss P Parkin N Berkhout B 《Journal of virology》2005,79(6):3536-3543
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