DREB2s转录因子基因的表达调控机制研究进展

DREB2s是植物特有的转录因子,隶属于AP2/EREBP转录因子家族,对干旱、高盐或低温、高温等非生物胁迫应答基因的表达有重要的调控作用。不同植物来源的DREB2在基因结构上有细微差异,对非生物胁迫的响应亦有不同表现。本文阐述了DREB2s的蛋白质结构特征及其对多种非生物胁迫的应答反应,并深入分析了DREB2s转录水平和转录后加工水平的表达调控分子机制的最新研究进展,为理解DREB2s基因功能、分子调控机制及作物抗逆基因工程提供理论依据。     

A Synechocystis LexA-orthologue binds direct repeats in target genes

Although evidence for LexA-orthologues, which do not regulate DNA damage repair, is accumulating, identification of binding sites and regulon members remains poorly characterized. In the cyanobacterium, Synechocystis sp. strain PCC 6803, we have recently identified a LexA-related protein that regulates expression of the crhR RNA helicase gene. Here we show that the Synechocystis LexA-orthologue binds as a dimer to 12 bp direct repeats containing a CTA-N9-CTA sequence conserved in two target genes, lexA and crhR. Characterization of this site provides the basis for identification of additional LexA targets and further evidence for LexA's divergence during evolution.     

线粒体转录终止因子蛋白家族研究进展

线粒体转录终止因子蛋白的作用是与线粒体DNA的特异位点结合,导致线粒体基因转录停止。近年来,随着人们对线粒体基因转录机制和人线粒体疾病的深入研究,线粒体转录终止因子的功能开始受到人们的关注。本文介绍了线粒体转录终止因子及其家族成员的研究进展和有待解决的一些问题。