Metabolic Reconfiguration in C. elegans Suggests a Pathway for Widespread Sterol Auxotrophy in the Animal Kingdom

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Predictable cholesterol binding sites in GPCRs lack consensus motifs

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Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility

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Role of dietary fiber in the recovery of the human gut microbiome and its metabolome

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LXR stimulates a metabolic switch and reveals cholesterol homeostasis as a statin target in Tasmanian devil facial tumor disease

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Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions

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Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory

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ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms

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Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion

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Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

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Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload

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Dietary restriction induces a sexually dimorphic type I interferon response in mice with gene-environment interactions

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Inhibition of ATP-citrate lyase improves NASH,liver fibrosis,and dyslipidemia

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NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer

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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

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Identifying functional metabolic shifts in heart failure with the integration of omics data and a heart-specific,genome-scale model

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Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism

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Phase 1/2a clinical trial in ALS with ropinirole,a drug candidate identified by iPSC drug discovery

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Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism

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Vaginal epithelial dysfunction is mediated by the microbiome,metabolome, and mTOR signaling

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