Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis

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Worksite-based intensive lifestyle therapy has profound cardiometabolic benefits in people with obesity and type 2 diabetes

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Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design

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Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy

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Inactivation of a wheat protein kinase gene confers broad-spectrum resistance to rust fungi

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FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance

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Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies

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Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma

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Defining and Targeting Adaptations to Oncogenic KRASG12C Inhibition Using Quantitative Temporal Proteomics

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Z-form extracellular DNA is a structural component of the bacterial biofilm matrix

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An Aphid-Secreted Salivary Protease Activates Plant Defense in Phloem

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PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK

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Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics

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CLIP-170S is a microtubule +TIP variant that confers resistance to taxanes by impairing drug-target engagement

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Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis

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Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention

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YAP1 and PRDM14 converge to promote cell survival and tumorigenesis

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Cryo-EM structure of the EspA filament from enteropathogenic Escherichia coli: Revealing the mechanism of effector translocation in the T3SS

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Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis

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Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis

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