H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

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RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

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BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation

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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

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Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling

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SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt

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IQGAP1 Negatively Regulates HIV-1 Gag Trafficking and Virion Production

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Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation

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TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation

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TRPS1 drives heterochromatic origin refiring and cancer genome evolution

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Atomic insights into ML-SI3 mediated human TRPML1 inhibition

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TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1

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Endothelin-1 drives invadopodia and interaction with mesothelial cells through ILK

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MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

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Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow

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Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors

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Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms

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E6AP AZUL interaction with UBQLN1/2 in cells,condensates, and an AlphaFold-NMR integrated structure

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Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A

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Extrinsic control and intrinsic computation in the hippocampal CA1 circuit

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