共查询到20条相似文献,搜索用时 15 毫秒
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正Coronaviruses are large, enveloped, positive-strand RNA viruses. Several coronaviruses are pathogenic in humans,including severe acute respiratory syndrome coronavirus(SARS-CoV), Middle East respiratory syndrome coronavirus(MERS-CoV) and this novel virus, SARS-CoV-2, 相似文献
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It has been more than a year since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged. Many studies have provided insights into the various aspects of the immune response in coronavirus disease 2019 (COVID-19). Especially for antibody treatment and vaccine development, humoral immunity to SARS-CoV-2 has been studied extensively, though there is still much that is unknown and controversial. Here, we introduce key discoveries on the humoral immune responses in COVID-19, including the immune dynamics of antibody responses and correlations with disease severity, neutralizing antibodies and their cross-reactivity, how long the antibody and memory B-cell responses last, aberrant autoreactive antibodies generated in COVID-19 patients, and the efficacy of currently available therapeutic antibodies and vaccines against circulating SARS-CoV-2 variants, and highlight gaps in the current knowledge. 相似文献
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《Cell》2022,185(10):1728-1744.e16
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《Cell host & microbe》2022,30(11):1512-1517.e4
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《Cell》2022,185(11):1875-1887.e8
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Jing-Yu Wang Tian-Ning Li Chun-Lei Zhou Jie Zhao Meng Wang Yuan Wang Yan Jiang He-Nan Dong Qian-Ru Qi Hong Mu 《中国病毒学》2022,37(6):850-859
COVID-19 has spread surprisingly fast worldwide, and new variants continue to emerge. Recently, the World Health Organization acknowledged a new mutant strain “Omicron”, with children were accounting for a growing share of COVID-19 cases compared with other mutant strains. However, the clinical and immunological characteristics of convalescent pediatric patients after Omicron infection were lacking. In this study, we comparatively analyzed the clinical data from pediatric patients with adult patients or healthy children and the effects of SARSCoV-2 vaccine on the clinical and immune characteristics in convalescent pediatric patients. Our results indicated that convalescent pediatric patients had unique clinical and immune characteristics different from those of adult patients or healthy children, and SARS-CoV-2 vaccination significantly affected on the clinical and immune characteristics and the prevention of nucleic acid re-detectable positive (RP) in convalescent patients. Our study further deepens the understanding of the impact of Omicron on the long-term health of pediatric patients and provides a valuable reference for the prevention and treatment of children infected with Omicron. 相似文献
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Zi-Wei Ye Yilan Fan Kaiming Tang Chon Phin Ong Cuiting Luo Hon-Lam Chung Tsun-Lam Leong Ronghui Liang Wai-Yin Lui Runhong Zhou Yun Cheng Lu Lu Pak-Hin Hinson Cheung Jasper Fuk-Woo Chan Zhiwei Chen Kwok-Yung Yuen Shuofeng Yuan Kelvin Kai-Wang To Dong-Yan Jin 《International journal of biological sciences》2022,18(12):4781
Rapid development and successful use of vaccines against SARS-CoV-2 might hold the key to curb the ongoing pandemic of COVID-19. Emergence of vaccine-evasive SARS-CoV-2 variants of concern (VOCs) has posed a new challenge to vaccine design and development. One urgent need is to determine what types of variant-specific and bivalent vaccines should be developed. Here, we compared homotypic and heterotypic protection against SARS-CoV-2 infection of hamsters with monovalent and bivalent whole-virion inactivated vaccines derived from representative VOCs. In addition to the ancestral SARS-CoV-2 Wuhan strain, Delta (B.1.617.2; δ) and Theta (P.3; θ) variants were used in vaccine preparation. Additional VOCs including Omicron (B.1.1.529) and Alpha (B.1.1.7) variants were employed in the challenge experiment. Consistent with previous findings, Omicron variant exhibited the highest degree of immune evasion, rendering all different forms of inactivated vaccines substantially less efficacious. Notably, monovalent and bivalent Delta variant-specific inactivated vaccines provided optimal protection against challenge with Delta variant. Yet, some cross-variant protection against Omicron and Alpha variants was seen with all monovalent and bivalent inactivated vaccines tested. Taken together, our findings support the notion that an optimal next-generation inactivated vaccine against SARS-CoV-2 should contain the predominant VOC in circulation. Further investigations are underway to test whether a bivalent vaccine for Delta and Omicron variants can serve this purpose. 相似文献
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Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant
Venkata Viswanadh Edara Carson Norwood Katharine Floyd Lilin Lai Meredith E. Davis-Gardner William H. Hudson Grace Mantus Lindsay E. Nyhoff Max W. Adelman Rebecca Fineman Shivan Patel Rebecca Byram Dumingu Nipuni Gomes Garett Michael Hayatu Abdullahi Nour Beydoun Bernadine Panganiban Nina McNair Mehul S. Suthar 《Cell host & microbe》2021,29(4):516-521.e3
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Alexandra Tauzin Manon Nayrac Mehdi Benlarbi Shang Yu Gong Romain Gasser Guillaume Beaudoin-Bussières Nathalie Brassard Annemarie Laumaea Dani Vézina Jérémie Prévost Sai Priya Anand Catherine Bourassa Gabrielle Gendron-Lepage Halima Medjahed Guillaume Goyette Julia Niessl Olivier Tastet Laurie Gokool Andrés Finzi 《Cell host & microbe》2021,29(7):1137-1150.e6
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Adam S. Olia Yaroslav Tsybovsky Steven J. Chen Cuiping Liu Alexandra F. Nazzari Li Ou Lingshu Wang Wing-Pui Kong Kwan Leung Tracy Liu Tyler Stephens I-Ting Teng Shuishu Wang Eun Sung Yang Baoshan Zhang Yi Zhang Tongqing Zhou John R. Mascola Peter D. Kwong 《The Journal of biological chemistry》2021,297(4)
The SARS-CoV-2 spike is the primary target of virus-neutralizing antibodies and critical to the development of effective vaccines against COVID-19. Here, we demonstrate that the prefusion-stabilized two-proline “S2P” spike—widely employed for laboratory work and clinical studies—unfolds when stored at 4 °C, physiological pH, as observed by electron microscopy (EM) and differential scanning calorimetry, but that its trimeric, native-like conformation can be reacquired by low pH treatment. When stored for approximately 1 week, this unfolding does not significantly alter antigenic characteristics; however, longer storage diminishes antibody binding, and month-old spike elicits virtually no neutralization in mice despite inducing high ELISA-binding titers. Cryo-EM structures reveal the folded fraction of spike to decrease with aging; however, its structure remains largely similar, although with varying mobility of the receptor-binding domain. Thus, the SARS-CoV-2 spike is susceptible to unfolding, which affects immunogenicity, highlighting the need to monitor its integrity. 相似文献
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《Cell》2021,184(17):4401-4413.e10
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《Cell host & microbe》2022,30(8):1093-1102.e3