The Human Erythroid-Specific Transcription Factor EKLF Localizes to Chromosome 19p13.12–p13.13

Erythroid Krüppel-like factor (EKLF) is atrans-acting factor that binds specifically to the β-globin promoter CACCC box. EKLF is essential for adult erythroid development in mice. We have cloned and sequenced a cDNA encoding the human homologue of this gene, which shares 69% identity with the mEKLF protein. The expression of hEKLF is restricted to fetal liver and adult bone marrow. The genomic locus of hEKLF was mapped to chromosomal band 19p13.12–p13.13, using fluorescencein situhybridization.