共查询到20条相似文献,搜索用时 15 毫秒
1.
《Molecular Biology》2011,45(4):691-692
Chronicle
On the 75th anniversary of the birth of L. L. Kiselev 相似文献2.
Nicholas Catsimpoolas 《Biophysics》2009,54(3):406-407
Chronicle
To the 70th anniversary of E. E. Fesenko 相似文献3.
4.
《Entomological Review》2009,89(7):878-879
Anniversary
On the 85th birthday of A. M. Lobanov The Russian entomological society 相似文献5.
80th birthday of A.N. Ilyaletdinov,Academician of the National Academy of the Republic of Kazakhstan
Chronicle
80th birthday of A.N. Ilyaletdinov, Academician of the National Academy of the Republic of Kazakhstan 相似文献6.
R. Schiffmann 《Glycoconjugate journal》2003,20(5):289-289
Biography
Biography of Dr. Roscoe O. Brady 相似文献7.
《Neurochemical research》2009,34(10):1695-1695
Dedication
Special Issue in Honor of Dr. Graham A. R. Johnston 相似文献8.
9.
Chunhua Shi Matthew F. Paige Jason Maley Michèle C. Loewen 《Biochimica et Biophysica Acta (BBA)/General Subjects》2009
Background
The S. cerevisiae α-factor receptor, Ste2p, is a G-protein coupled receptor that plays key roles in yeast signaling and mating. Oligomerization of Ste2p has previously been shown to be important for intracellular trafficking, receptor processing and endocytosis. However the role of ligand in receptor oligomerization remains enigmatic.Methods
Using functional recombinant forms of purified Ste2p, atomic force microscopy, dynamic light scattering and chemical crosslinking are applied to investigate the role of ligand in Ste2p oligomerization.Results
Atomic force microscopy images indicate a molecular height for recombinant Ste2p in the presence of α-factor nearly double that of Ste2p alone. This observation is supported by complementary dynamic light scattering measurements which indicate a ligand-induced increase in the polydispersity of the Ste2p hydrodynamic radius. Finally, chemical cross-linking of HEK293 plasma membranes presenting recombinant Ste2p indicates α-factor induced stabilization of the dimeric form and higher order oligomeric forms of the receptor upon SDS-PAGE analysis.Conclusions
α-factor induces oligomerization of Ste2p in vitro and in membrane.General significance
These results provide additional evidence of a possible role for ligand in mediation of Ste2p oligomerization in vivo. 相似文献10.
Anniversaries
Daniil S. Vorontsov (On the 125th Anniversary of His Birthday) 相似文献11.
《Insectes Sociaux》2012,59(1):139-140
Annual Report
International Union for the Study of Social Insects Report of Secretary-General Joan M. Herbers 2011 Annual Report 相似文献12.
Michele Masellis 《Cell and tissue banking》2005,6(3):241-242
Announcement
Award of the G. Whitaker International Burns Prize for 2005 Palermo, Italy 相似文献13.
Background
Diabetes costs represent a large burden to both patients and the health care system. However, few studies that examine the economic consequences of diabetes have distinguished between the two major forms, type 1 and type 2 diabetes, despite differences in underlying pathologies. Combining the two diseases implies that there is no difference between the costs of type 1 and type 2 diabetes to a patient. In this study, we examine the costs of type 1 diabetes, which is often overlooked due to the larger population of type 2 patients, and compare them to the estimated costs of diabetes reported in the literature.Methodology/Principal Findings
Using a nationally representative dataset, we estimate yearly and lifetime medical and indirect costs of type 1 diabetes by implementing a matching method to compare a patient with type 1 diabetes to a similar individual without the disease. We find that each year type 1 diabetes costs this country $14.4 billion (11.5–17.3) in medical costs and lost income. In terms of lost income, type 1 patients incur a disproportionate share of type 1 and type 2 costs. Further, if the disease were eliminated by therapeutic intervention, an estimated $10.6 billion (7.2–14.0) incurred by a new cohort and $422.9 billion (327.2–519.4) incurred by the existing number of type 1 diabetic patients over their lifetime would be avoided.Conclusions/Significance
We find that the costs attributed to type 1 diabetes are disproportionately higher than the number of type 1 patients compared with type 2 patients, suggesting that combining the two diseases when estimating costs is not appropriate. This study and another recent contribution provides a necessary first step in estimating the substantial costs of type 1 diabetes on the U.S. 相似文献14.
《Insectes Sociaux》2011,58(1):137-137
Annual Report
International Union for the Study of Social Insects Report of Secretary-General Joan M. Herbers 2010 Annual Report 相似文献15.
《Medizinische Genetik》2012,24(1):73-73
Patientenorganisationen - Selbsthilfegruppen
Netzwerk Hypophysen- und Nebennierenerkrankungen e.V. 相似文献16.
In a previous article (8) a geometrical study of the five-membered ring showed that: a) for the case of the 20 symmetrical C2 and Cs conformations, the pseudorotation formulae for the torsion angles are a geometrical property of the ring; b) geometrical considerations alone are unable to define the puckering amplitude, the bond angle values, and the pathway between two symmetrical conformations. Here we examine how the energy equations enable us to define the deformation amplitude
m, establish the bond angles expressions and check the energy invariability along the pseudorotation circuit. The problem is next developed fully in the case where the bond and torsional energy only are considered: the literal expression1 of
m is then given as a function of the bond angle which cancels out the bond angle energy. A numerical application is carried out on cyclopentane and the values of the parameters Kt, K1 and used in the Conformational energy calculations are considered.Notations used 1 i
bond lengths 1 in the case of the regular ring
-
i
torsional angles
-
i
bond angles
-
3/5 = 108
-
4/5 = 144
-
,
i
i – = complement to the 108 bond angle
i
-
T
-
E
Conformational energy of the 5-membered ring
-
E
Conformational energy difference between planar and deformed ring
-
A
n
Coefficients of the energy development in terms of
-
E
i
l
Bond energy relative to atom i (associated with angle
i)
-
K
i
l
Bond constant relative to atom i (associated with angle
i)
-
E
i
l
Torsional energy relative to the i
th bond (associated with angle
i)
-
k
i
l
Torsional constant relative to the i
th bond (associated with angle
i)
-
i
Angle
i value corresponding to zero bond energy E
i
l
(when the 5 atoms of the ring are identical,
i )
-
r
ij
Distance between atoms i and j
-
q
i
Charge carried by atom i
-
e
Constant of proportionality including the effective dielectric constant
-
A
ij, Bij, dij
Coefficients dependent on the nature of the atoms i and j and accounted for in the Van der Waals energy and hydrogen bond expressions
-
S (r
ij)
Electrostatic contribution to the hydrogen bond energy
-
P
Pseudorotation phase angle
-
m
Maximum torsional angle value characterising the deformation amplitudeM 相似文献
17.
Walter Gams 《Mycopathologia》2004,158(3):395-396
Book Review
Book Review:R.J. Cole, B.B. Jarvis and M.A. Schweikert eds.Handbook of Secondary Fungal metabolites, AcademicPress, UK, 2003. 2544 pp. $299.95. 相似文献18.
Organizers Abstracts of the Annual Symposium of the Czechoslovak Society of Histochemistry Cytochemistry 《The Histochemical journal》2001,33(4):231-251
Abstract List
Abstracts of the Annual Symposium of the Czech Society of Histochemistry and Cytochemistry 相似文献19.
Donald E. Osterbrock 《Glycoconjugate journal》2003,20(1):7-7
Biography
Biography of Professor Dr. Saul Roseman 相似文献20.
Joseph Harris 《Neurochemical research》2001,26(6):1 p preceding 569, 569-1 p preceding 569, 764