共查询到20条相似文献，搜索用时 31 毫秒
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Introduction
Validity of biomarkers may be affected if studies do not include certain features in their design. We evaluated whether translational research studies of potential biomarkers incorporated design features important for valid clinical associations. 相似文献2.
Carlos J Bidot Lawrence L Horstman Wenche Jy Joaquin J Jimenez Carlos BidotJr Yeon S Ahn J Steven Alexander Eduardo Gonzalez-Toledo Roger E Kelley Alireza Minagar 《BMC neurology》2007,7(1):36
Background
The presence of antiphospholipid antibodies (APLA) in multiple sclerosis (MS) patients has been reported frequently but no clear relationship between APLA and the clinical and neuroimaging features of MS have heretofore been shown. We assessed the clinical and neuroimaging features of MS patients with plasma APLA. 相似文献3.
Tormod Mørk Steinar Waage Tore Tollersrud Bjørg Kvitle Ståle Sviland 《Acta veterinaria Scandinavica》2007,49(1):23
Background
Clinical mastitis is an important disease in sheep. The objective of this work was to identify causal bacteria and study certain epidemiological and clinical features of clinical mastitis in ewes kept for meat and wool production. 相似文献4.
Ishimori ML Altman RD Cohen MJ Cui J Guo X Rotter JI Weisman MH 《Arthritis research & therapy》2010,12(5):R180
Introduction
The objective of the present study was to assess heritability of clinical and radiographic features of hand osteoarthritis (OA) in affected patients and their siblings. 相似文献5.
Background
Headache has been reported to be associated with mobile phone (MP) use in some individuals. The causal relationship between headache associated with MP use (HAMP) and MP use is currently undetermined. Identifying the clinical features of HAMP may help in clarifying the pathophysiology of HAMP and in managing symptoms of individuals with HAMP. The aim of the present study is to describe the clinical features of HAMP. 相似文献6.
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Introduction
Although systemic autoimmune diseases (SAID) share many clinical and laboratory features, whether they also share some common features of pathogenesis remains unclear. We assessed plasma proteomic profiles among different SAID for evidence of common molecular pathways that could provide insights into pathogenic mechanisms shared by these diseases. 相似文献8.
Pamela A Raymond Linda K Barthel Rebecca L Bernardos John J Perkowski 《BMC developmental biology》2006,6(1):36-17
Background
The persistence in adult teleost fish of retinal stem cells that exhibit all of the features of true 'adult stem cells' – self-renewal, multipotency, and the capacity to respond to injury by mitotic activation with the ability to regenerate differentiated tissues – has been known for several decades. However, the specialized cellular and molecular characteristics of these adult retinal stem cells and the microenvironmental niches that support their maintenance in the differentiated retina and regulate their activity during growth and regeneration have not yet been elucidated. 相似文献9.
Elena Schiopu Kristine Phillips Paul M MacDonald Leslie J Crofford Emily C Somers 《Arthritis research & therapy》2012,14(1):R22-9
Introduction
The idiopathic inflammatory myopathies are rare diseases for which data regarding the natural history, response to therapies and factors affecting mortality are needed. We performed this study to examine the effects of treatment and clinical features on survival in polymyositis and dermatomyositis patients. 相似文献10.
Fikre Lobago Hans Gustafsson Merga Bekana Jean-François Beckers Hans Kindahl 《Acta veterinaria Scandinavica》2006,48(1):23-9
Background
The present study describes the clinical features and plasma profiles of bovine pregnancy-associated glycoprotein 1 (bPAG1), the main metabolite of prostaglandin F2α (PG metabolite) and progesterone (P4) in heifers in which early abortions were induced. 相似文献11.
Karin Hayashi Mariko Makino Masahiro Hashizume Koichi Nakano Koji Tsuboi 《BioPsychoSocial medicine》2010,4(1):9
Background
Since the 1980s, a high EEG abnormality rate has been reported for patients with panic disorder. However, how the EEG abnormalities of panic disorder patients are related to the clinical features and pathology of these patients has yet to be clarified. In this study we investigated whether or not EEG abnormalities are related to the 13 symptoms in the DSM-IV criteria for a diagnosis of panic attacks. 相似文献12.
Victoria Cano David Moranta Enrique Llobet-Brossa José Antonio Bengoechea Junkal Garmendia 《BMC microbiology》2009,9(1):156
Background
Klebsiella pneumoniae is a capsulated Gram negative bacterial pathogen and a frequent cause of nosocomial infections. Despite its clinical relevance, little is known about the features of the interaction between K. pneumoniae and lung epithelial cells on a cellular level, neither about the role of capsule polysaccharide, one of its best characterised virulence factors, in this interaction. 相似文献13.
Background
Tiling array data is hard to interpret due to noise. The wavelet transformation is a widely used technique in signal processing for elucidating the true signal from noisy data. Consequently, we attempted to denoise representative tiling array datasets for ChIP-chip experiments using wavelets. In doing this, we used specific wavelet basis functions, Coiflets, since their triangular shape closely resembles the expected profiles of true ChIP-chip peaks. 相似文献14.
Background
Proteins are dynamic molecules that exhibit a wide range of motions; often these conformational changes are important for protein function. Determining biologically relevant conformational changes, or true variability, efficiently is challenging due to the noise present in structure data. 相似文献15.
Spiridon Papapetropoulos Heather Katzen Anette Schrag Carlos Singer Blake K Scanlon Daniel Nation Alexandra Guevara Bonnie Levin 《BMC neurology》2008,8(1):21
Background
Hallucinations occur in 20–40% of PD patients and have been associated with unfavorable clinical outcomes (i.e., nursing home placement, increased mortality). Hallucinations, like other non-motor features of PD, are not well recognized in routine primary/secondary clinical practice. So far, there has been no instrument for uniform characterization of hallucinations in PD. To this end, we developed the University of Miami Parkinson's disease Hallucinations Questionnaire (UM-PDHQ) that allows comprehensive assessment of hallucinations in clinical or research settings. 相似文献16.
Gunnhild Berdal Silje Halvorsen Désirée van der Heijde Morten Mowe Hanne Dagfinrud 《Arthritis research & therapy》2012,14(1):R19-10
Introduction
Pulmonary involvement is a known manifestation in patients with ankylosing spondylitis (AS). However, previous studies have been based on small samples and the reported prevalence and associations with typical clinical features vary. The purpose of this study was to compare pulmonary function (PF) in patients with AS and population controls, and to study associations between PF and disease related variables, cardio-respiratory fitness and demographic variables in patients with AS. 相似文献17.
Background
Remote health monitoring plays a major role in handling the critical situation of patients and avoiding death and also enhancing the quality of healthcare services. The effective real time monitoring with accurate decision has to be made in advance with the help of decision making system by continuously acquiring biosignals.Objectives
The main objective was to outline the research on remote patient health monitoring system that constitutes the multimodal biosignal acquisition system, thereby providing multi-label classification and clinical decision support system (CDSS).Methods and results
A review was conducted with search terms such as multi-label classification, clinical decision support system, context-awareness and remote health monitoring. The study criteria included the randomized clinical trials evaluating the impact of efficient remote health monitoring system which incorporates CDSS for context-awareness systems by correlating several vital signs. From the total papers () which were included in the review, the major concentration of the review is multi-label classification (, 40%). Further, this article included the review in context-awareness methods (, 10%), clinical decision support systems (, 23%), different means of biosignal acquisition and pre-processing (, 10%), databases and software techniques for developing learning algorithms (, 6%) and from general category (, 12%). Several studies were effectively included which provides faster diagnosis for critically ill-patients. It is decisive for the critically ill-patients to be treated at the right time with proper and effective treatment which can be done efficiently using the CDSS and multi-label classification. The disease labels are classified as single and multi-labels where multi-label classification includes the disease labels for the correlated multiple vital signs and single label classification includes disease labels for individual vital signs. Further, on developing the logical learning model using multi-label classification, decision support system can be enhanced using context-awareness methods to predict the future vital signs, thereby providing an alert to the patients or doctors to take necessary actions.Conclusion
The proposed system includes the model that provides the correlations of several biosignals like electrocardiogram (ECG), peripheral capillary oxygen saturation (SPO2), body temperature and heartbeat, thereby identifying the critical situations and making the decisions using CDSS that helps in taking the necessary clinical interventions. 相似文献18.
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