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1.
摘要 目的:研究血清尿酸(UA)、同型半胱氨酸(Hcy)、白细胞介素-6(IL-6)与冠心病患者肠道菌群和主要不良心血管事件(MACE)的关系。方法:选取2018年5月~2020年12月期间在中国人民解放军联勤保障部队第九八九医院行经皮冠状动脉介入术(PCI)的冠心病患者120例作为冠心病组,选取同期来中国人民解放军联勤保障部队第九八九医院体检的健康志愿者80例作为对照组。对比对照组、冠心病组的血清IL-6、Hcy、UA水平和乳酸杆菌、双歧杆菌、大肠杆菌。Pearson相关性分析IL-6、Hcy、UA和乳酸杆菌、双歧杆菌、大肠杆菌的相关性。记录冠心病组PCI术后随访1年MACE的发生率,并采用多因素Logistic回归分析MACE发生的影响因素。结果:冠心病组的血清IL-6、Hcy、UA水平高于对照组(P<0.05)。冠心病组的乳酸杆菌、双歧杆菌、大肠杆菌数量少于对照组(P<0.05)。Pearson相关性分析结果显示,IL-6、Hcy、UA均与乳酸杆菌、双歧杆菌、大肠杆菌呈负相关(P<0.05)。所有患者均完成随访,无失访患者。随访过程中发现有32例患者发生MACE,发生率为26.67%。根据是否发生MACE分为MACE组(n=32)和无MACE组(n=88)。单因素分析结果显示,MACE的发生与病程、吸烟史、合并高血压、合并糖尿病、置入支架数目、IL-6、Hcy、UA、乳酸杆菌、双歧杆菌、大肠杆菌有关(P<0.05)。多因素Logistic回归分析结果显示:病程偏长、吸烟史、合并高血压、合并糖尿病、置入支架数目更多、IL-6偏高、Hcy偏高、UA偏高是冠心病患者MACE发生的危险因素(P<0.05)。结论:冠心病患者体内IL-6、Hcy、UA水平升高,肠道菌群紊乱,且肠道菌群紊乱与IL-6、Hcy、UA水平相关。此外,冠心病PCI术后MACE发生不可避免,且受到病程、吸烟史、合并高血压等多种因素的影响。 相似文献
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摘要 目的:探讨血清铁蛋白(Ferritin)、组织蛋白酶S(Cat S)、单核细胞趋化蛋白-1(MCP-1)与妊娠期糖尿病(GDM)患者胰岛素抵抗的关系,并分析影响GDM患者妊娠结局的影响因素。方法:选取2019年4月~2021年12月期间来石家庄市妇幼保健院产检并诊断为GDM的产妇154例纳为GDM组,另取同期来石家庄市妇幼保健院产检的健康产妇100例作为对照组。检测对比两组的血清Ferritin、Cat S、MCP-1水平以及稳态模型胰岛素抵抗指数(HOMA-IR),血清Cat S、Ferritin、MCP-1与HOMA-IR的相关性以Pearson相关系数进行分析。GDM组患者根据妊娠结局分为正常妊娠结局组和不良妊娠结局组,妊娠结局的影响因素采用多因素Logistic回归分析。结果:GDM组血清Ferritin、Cat S、MCP-1水平及HOMA-IR均高于对照组(P<0.05)。Pearson相关性分析结果显示,GDM患者的血清Cat S、Ferritin、MCP-1水平与HOMA-IR均呈正相关(P<0.05)。154例GDM患者中,有58例出现不良妊娠结局,占比37.66%。单因素分析结果显示,GDM患者的妊娠结局与糖尿病家族史、GDM确诊时孕周、年龄、口服葡萄糖耐量试验(OGTT)结果、孕前体质量指数(BMI)、血清Ferritin、Cat S、MCP-1水平以及HOMA-IR有关(P<0.05)。多因素Logistic回归分析结果显示:年龄≥35岁、孕前BMI≥24 kg/m2、OGTT结果>2项异常、血清Ferritin、Cat S、MCP-1水平偏高是GDM患者妊娠结局不良的危险因素(P<0.05)。结论:GDM患者的血清Ferritin、Cat S、MCP-1水平异常升高,且与胰岛素抵抗有关。GDM患者的妊娠结局受到血清Ferritin、Cat S、MCP-1水平、年龄、孕前BMI、OGTT结果等因素影响。 相似文献
3.
摘要 目的:考察心力衰竭患者血清中内源性Apela、N端脑钠肽前体(NT-proBNP)、白细胞介素-6(IL-6)水平与心室重塑、心脏储备功能的相关性。方法:选取2018年5月至2021年5月,120例急性心肌梗死(AMI)后心力衰竭患者纳入研究。参与者被分为两组:心室重构组(n=51)和非心室重构组(n=69),另选取同期体检的47名健康受试者作为对照。除了左心室壁厚度(LVWT)和左心室质量指数(LVMI)外,还测量了血清内源性Apela、NT-proBNP和IL-6表达水平。分析血清内源性Apela、NT-proBNP和IL-6与LVWT、LVMI的相关性,评价其预测心室重构的价值。采用6MWT值、D/S值和ΔWMSI评估心脏储备功能。结果:三组左心室壁厚度(LVWT)和LVMI具有差异(P<0.05);与对照组相比,心室重塑组和非心室重塑组血清内源性Apela水平较低,而IL-6和NT-proBNP水平较高。心室重塑组Apela水平低于非心室重塑组,而IL-6和NT-proBNP水平高于非心室重塑组。三组间血清内源性Apela、IL-6、NT-proBNP水平有差异(P<0.05);在AMI后心力衰竭患者中,血清内源性Apela与LVWT和LVMI呈显著负相关(r=-0.485,-0.428;P=0.001,0.007)。此外,血清IL-6、NT-proBNP与LVWT和LVMI呈显著正相关(r=0.512,0.426;P=0.000,0.000)(r=0.592,0.530;P=0.000,0.000);在AMI后心力衰竭患者中,血清内源性Apela水平与6WMD和D/S呈显著负相关(r=-0.659,-0.561;P=0.001,0.001)。此外,血清IL-6水平、NT-proBNP水平与6WMD和D/S呈显著正相关(r=0.203,0.381;P=0.000,0.000)(r=0.521,0.481;P=0.000, 0.000);Logistic回归分析显示,血清Apela水平越低,血清IL-6和NT-proBNP水平越高,心室重塑的可能性越大。因此,血清内源性Apela、IL-6、NT-proBNP和Killip分级是心室重塑的危险因素。结论:早期联合检测血清内源性Apela、IL-6和 NT-proBNP水平可提高预测心室重塑的准确性,有助于AMI后心力衰竭的早期防治。 相似文献
4.
摘要 目的:观察健脾益肾活血方联合达格列净对糖尿病肾病(DN)患者炎症因子、氧化应激和血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、晚期糖基化终末产物(AGEs)、单核细胞趋化蛋白1(MCP-1)的影响。方法:根据随机数字表法将如皋市中医院2021年6月~2023年3月期间收治的120例DN患者分为对照组(60例,常规治疗基础上接受达格列净治疗)和研究组(60例,对照组基础上接受健脾益肾活血方治疗)。对比两组疗效、炎症因子[白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]、肾功能[血肌酐(Scr)、血尿素氮(BUN)、尿微量白蛋白/肌酐比值(UACR)]、氧化应激[丙二醛(MDA)、超氧化物歧化酶(SOD)]和血清AGEs、NGAL、MCP-1水平,同时观察两组治疗期间不良反应发生情况。结果:研究组的临床总有效率高于对照组(P<0.05)。两组治疗2个疗程后Scr、BUN、UACR下降,且研究组低于对照组(P<0.05)。两组治疗2个疗程后CRP、TNF-α、IL-1β下降,且研究组低于对照组(P<0.05)。两组治疗2个疗程后MDA下降,且研究组低于对照组;SOD升高,且研究组高于对照组(P<0.05)。两组治疗2个疗程后NGAL、AGEs、MCP-1下降,且研究组低于对照组(P<0.05)。两组不良反应发生率对比未见差异(P>0.05)。结论:健脾益肾活血方联合达格列净可有效减轻DN患者氧化应激和炎症反应,调节血清AGEs、NGAL、MCP-1水平。 相似文献
5.
摘要 目的:探讨中药灌肠对宫颈癌急性放射性直肠炎(ARP)患者临床疗效及血清白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)水平的影响。方法:选取2021年3月-2023年3月期间在邵阳市中心医院收治行放疗的宫颈癌ARP患者180例,采用随机数字表法将患者分为A组(常规治疗,n=90)和B组(A组的基础上接受中药灌肠,n=90)。观察两组临床疗效、放射损伤疗效、中医证候积分和IL-1β、IL-8、TNF-α水平变化情况,并对比不同放射性直肠炎分级患者的血清IL-1β、IL-8、TNF-α水平。结果:B组的临床总有效率高于A组(P<0.05)。两组治疗后黏液血便、腹痛、里急后重、稀便或便秘、肛门灼痛坠痛、口干口苦、尿赤等证候积分下降,且B组低于A组(P<0.05)。B组的放射损伤总有效率高于A组(P<0.05)。放射性直肠炎分级III级、Ⅱ级血清IL-1β、IL-8、TNF-α水平高于I级,且III级高于Ⅱ级(P<0.05)。两组治疗后血清IL-1β、IL-8、TNF-α水平下降,且B组低于A组(P<0.05)。结论:中药灌肠治疗宫颈癌ARP患者,可提高临床疗效,改善临床症状,可能与改善血清IL-1β、IL-8、TNF-α水平有关。 相似文献
6.
摘要 目的:分析早产儿血清炎性因子与生长发育指标的关系及对新生儿呼吸窘迫综合征(RDS)的预测效能。方法:选择2018年1月至2020年10月在我院出生的98例早产儿作为研究对象,根据是否并发RDS,分为RDS组(58例)和非RDS组(40例)。检测两组血清白细胞介素-1β(IL-1β)、IL-6、IL-8、肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)水平,记录生长发育指标,通过Pearson相关性分析早产儿血清炎性因子与生长发育指标的关系,使用受试者工作特征曲线(ROC)分析血清炎性因子对新生儿呼吸窘迫综合征的预测效能。结果:RDS组血清IL-1β、IL-6、IL-8、TNF-α、PCT水平均高于非RDS组(P<0.05);RDS组胎龄、出生体重均小于非RDS组(P<0.05);经Pearson相关性分析,早产儿血清IL-1β、IL-6、IL-8、TNF-α、PCT水平均与胎龄、出生体重呈负相关(P<0.05);经多因素Logistic回归分析,IL-1β、IL-6、IL-8、TNF-α、PCT均是早产儿并发新生儿呼吸窘迫综合征的独立危险因素(P<0.05);经ROC曲线分析,IL-1β、IL-6、IL-8、TNF-α联合PCT预测早产儿并发新生儿呼吸窘迫综合征的AUC为0.910。结论:早产儿血清IL-1β、IL-6、IL-8、TNF-α均与胎龄及出生体重密切相关,这些炎性因子联合预测RDS发生的效能较好,值得临床予以重视应用。 相似文献
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摘要 目的:探讨支气管哮喘患儿血清硫化氢(H2S)、嗜酸性粒细胞趋化因子(Eotaxin)水平与炎症因子及肺功能的关系。方法:选取我院收治的95例支气管哮喘患儿,按照《儿童支气管哮喘诊断及防治指南(2016年版)》将支气管哮喘患儿分为急性发作期组43例和缓解期组52例。检测血清中H2S 水平;检测Eotaxin、肿瘤坏死因子-α(TNF-α),白介素6(IL-6)和白介素13(IL-13)的水平;对患儿进行肺功能测定,采用Pearson检验分析血清H2S、Eotaxin水平与血清炎症因子及肺功能之间的相关性。ROC曲线分析血清H2S、Eotaxin对支气管哮喘患儿病情的预测价值。结果:急性发作期组患儿血清H2S水平、第一秒用力呼气容积占预计值百分比(FEV1%pred)、最大呼气流量占预计值百分比(PEF%pred)和FEV1/用力肺活量(FVC)低于缓解期组患儿,Eotaxin、TNF-α、IL-6和IL-13水平高于缓解期组患儿(P<0.05);支气管哮喘患儿血清H2S水平与TNF-α、IL-6和IL-13水平均呈负相关(P<0.05),与FEV1%pred、FEV1/FVC和PEF%pred均呈正相关(P<0.05);支气管哮喘患儿血清Eotaxin水平与TNF-α、IL-6和IL-13水平均呈正相关(P<0.05),与FEV1%pred、FEV1/FVC和PEF%pred均呈负相关(P<0.05)。血清H2S预测支气管哮喘患儿病情的曲线下面积为0.854,灵敏度和特异度分别为77.89%和81.05%,Youden指数为0.5894;血清Eotaxin预测支气管哮喘患儿病情的曲线下面积为0.924,灵敏度和特异度分别为92.71%和84.38%,Youden指数为0.7709。结论:支气管哮喘急性发作期患儿与缓解期患儿相比,其血清H2S水平较低,Eotaxin水平较高,血清H2S和Eotaxin水平与机体炎症反应及肺功能密切相关,有助于辅助评估支气管哮喘患儿的病情。 相似文献
8.
摘要 目的:探讨化脓性牙髓炎患者血清C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子α(TNF-α)及白细胞分化抗原-14 (CD14)水平的变化及其临床意义。方法:选取2016年1月~2017年12月期间本院收治的110例化脓性牙髓炎患者为研究组,其中急性化脓性牙髓炎患者59例(急性组),慢性化脓性牙髓炎患者51例(慢性组),另选同期在我院进行健康检查的健康受试者50例为对照组。放射免疫分析法检测对照组体检时、研究组患者治疗前后血清CRP、IL-6、TNF-α及CD14水平。Pearson相关性分析化脓性牙髓炎患者治疗前血清CRP、IL-6、TNF-α与CD14水平的相关性。结果:研究组患者治疗前血清CRP、IL-6、TNF-α、CD14水平均高于对照组体检时各项指标水平,组间对比差异有统计学意义(P<0.05)。急性组患者治疗前后血清CRP、IL-6、TNF-α、CD14水平均高于慢性组患者(P<0.05);急性组、慢性组患者治疗后血清CRP、IL-6、TNF-α、CD14水平均低于治疗前(P<0.05)。Pearson相关性分析结果显示,化脓性牙髓炎患者治疗前血清CRP、IL-6、TNF-α与CD14水平均呈正相关(P<0.05)。结论:化脓性牙髓炎患者血清CRP、IL-6、TNF-α及CD14均呈现高表达,可能参与了化脓性牙髓炎的发生、发展过程,经牙髓根管治疗后上述指标水平均降低,且CD14与血清CRP、IL-6、TNF-?琢呈正相关,可能作为评估化脓性牙髓炎病情的重要指标。 相似文献
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摘要 目的:探析冠心病(CHD)合并肾功能不全(RI)应用冠状动脉心脏介入治疗(PCI)联合尼可地尔的临床疗效及对胱抑素C(Cys-C)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)影响。方法:选择本院2019年6月~2021年6月就诊的86例CHD合并RI患者,随机数字表法分为两组各43例。 两组均实施PCI治疗,对照组实施常规静脉水化处理,观察组联合尼可地尔治疗。对比两组PCI治疗前后24 h肾功能指标(Cys-C、NGAL)、血清炎性因子指标(高敏C反应蛋白 (hs-CRP)、白细胞介素 6 (IL-6))、心肌损伤指标(心肌肌钙蛋白I(cTnI)及肌酸激酶同工酶(CK-MB))、并发症发生率。结果:观察组CIN发生率(2.33%)、MACE率(2.33%)均明显低于对照组(16.28%、13.95%),有统计学差异(P<0.05)。两组PCI治疗前Cys-C、NGAL、hs-CRP、IL-6、cTnI、CK- MB无统计学差异(P<0.05)。治疗后观察组Cys-C、NGAL、hs-CRP、IL-6升高幅度、组cTnI、CK- MB明显低于对照组(P<0.05)。结论:PCI 联合尼可地尔应用于CHD合并RI临床治疗效果显著,可有效改善患者肾功能,降低炎症反应、心肌损伤,预防CIN发生。 相似文献
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摘要 目的:探讨冠心病(CHD)患者血清CXC亚族趋化因子受体(CXCR)3、C-X-C趋化因子配体(CXCL)5、CXCL12水平与冠状动脉病变程度和预后的关系。方法:选择2018年2月至2020年2月我院心脏内科收治的189例CHD患者(CHD组),根据Gensini积分将患者分为轻度病变组(≤20分,62例)、中度病变组(21~40分,84例)和重度病变组(>40分,43例),根据随访期间是否发生主要心血管不良事件(MACE)将患者分为MACE组(45例)和无MACE组(144例),另选择102例同期于我院进行健康体检志愿者为对照组。检测血清CXCR3、CXCL5、CXCL12水平,分析其与CHD患者随访期间发生MACE的关系。结果:CHD组血清CXCR3、CXCL5、CXCL12水平高于对照组(P<0.05),重度病变组血清CXCR3、CXCL5、CXCL12水平高于中度病变组和轻度病变组(P<0.05),中度病变组血清CXCR3、CXCL5、CXCL12水平高于轻度病变组(P<0.05)。单因素分析结果显示,左心室射血分数(LVEF)、高血压、糖尿病、高脂血症、血糖、冠脉病变支数、冠脉病变长度、Gensini积分、血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、CXCR3、CXCL5、CXCL12水平与CHD患者随访期间发生MACE有关(P<0.05)。多因素Logistic回归分析显示,冠脉病变支数、高血压、CXCR3、CXCL5、CXCL12是CHD患者随访期间发生MACE的影响因素(P<0.05)。结论:CHD患者血清CXCR3、CXCL5、CXCL12水平均增高,且与冠状动脉病变加重和MACE发生有关,检测血清CXCR3、CXCL5、CXCL12有助于评估CHD患者的病情和预后。 相似文献
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Lawrence A. Pervin 《Human ecology: an interdisciplinary journal》1978,6(1):71-105
A review is presented of issues relevant to the definition, measurement, and classification of stimuli, situations, and environments. Problems such as the lack of adequate definitions of concepts, error and bias in measurement procedures, confusion between measurement of a concept and measurement of its behavioral effects, and the lack of agreement among alternative measures are emphasized. It is suggested that concepts be defined in terms of objective characteristics while allowing for the study of the transactional relationship between organism and environment. The work of the ethologists in defining stimuli while studying their relationship to different organismic states and situational contexts is emphasized in this regard. Following Brunswik, it is also suggested that wherever possible there be a representative sampling of variables in natural settings.
Note from the editors: From time to time, Human Ecology will publish a review article. Our first in this series is a review by a psychologist of basic definitional and conceptual problems in environmental studies.This paper was prepared while the author was a Visiting Research Fellow at the Educational Testing Service. The support of ETS and my colleagues in the Division of Psychological Studies is gratefully acknowledged. The review was also supported in part by a grant from the Rutgers University Research Council. 相似文献
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Haidet G. C.; Musch T. I.; Ordway G. A.; Mitchell J. H. 《Journal of applied physiology》1985,58(6):2047-2053
We compared the cardiovascular effects evoked in conscious dogs by 1) submaximal exercise; 2) infusion of dobutamine (40 micrograms X kg-1 X min-1); and 3) infusion of a combination of atropine (0.15 mg/kg), norepinephrine (0.19 micrograms X kg-1 X min-1), and epinephrine (0.05 micrograms X kg-1 X min-1). Myocardial O2 demand, as estimated by the double product (heart rate X systolic blood pressure), was similar during all three interventions. Cardiac output and heart rate increased significantly (P less than 0.05) during each of the three interventions. Arteriovenous O2 difference and total body O2 consumption, however, increased only during submaximal exercise. Although myocardial blood flow increased similarly during each of the three interventions, blood flow to skeletal muscle and the tongue increased only during exercise. Exercise and the combined infusion of atropine, norepinephrine, and epinephrine produced similar increases in blood flow to the diaphragm and similar decreases in blood flow to the stomach. These changes in blood flow were associated with appropriate changes in vascular resistance. Additionally, blood flow to the brain, kidney, adrenal glands, liver, and intestine did not change during any of the three interventions. Thus, in dogs, submaximal exercise, infusion of dobutamine, and infusion of a combination of atropine, norepinephrine, and epinephrine to evoke a given level of estimated myocardial O2 consumption produce similar increases in cardiac output, heart rate, and myocardial blood flow. In contrast, the changes in total body O2 consumption, arteriovenous O2 difference, regional blood flow, and regional vascular resistance that occur during each of these three interventions are different. 相似文献
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A. Peter Castro 《American anthropologist》2003,105(1):187-189
Indians, Markets, and Rainforests: Theory, Methods, and Analysis. Ricardo A. Godoy. New York: Columbia University Press, 2001. 274 pp. 相似文献
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2-Dimethylaminomethylene-1-benzosuberone 1 was coupled with diazotized aniline derivatives to afford a series of the hitherto unreported 2-arylazo-1-benzosuberones 3a–i. The tautomeric structure and the effect of substituents on the tautomeric form (s) of the products 3a–i were discussed. Similar coupling of the enaminone 1 with diazonium salts of heterocyclic amines gave the respective fused azolotriazino-benzosuberones. Some of the newly synthesized compounds showed potent antimicrobial, anti-HCV, antioxidant, antitumor (as topoisomerase I inhibitors), and antimicrobial activities. 相似文献
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Nicholas A. Ashford 《人类与生态风险评估》2005,11(1):85-96
The Precautionary Principle is in sharp political focus today because (1) the nature of scientific uncertainty is changing and (2) there is increasing pressure to base governmental action on more “rational” schemes, such as cost-benefit analysis and quantitative risk assessment, the former being an embodiment of ‘rational choice theory’ promoted by the Chicago school of law and economics. The Precautionary Principle has been criticized as being both too vague and too arbitrary to form a basis for rational decision making. The assumption underlying this criticism is that any scheme not based on cost-benefit analysis and risk assessment is both irrational and without secure foundation in either science or economics. This paper contests that view and makes explicit the rational tenets of the Precautionary Principle within an analytical framework as rigorous as uncertainties permit, and one that mirrors democratic values embodied in regulatory, compensatory, and common law. Unlike other formulations that reject risk assessment, this paper argues that risk assessment can be used within the formalism of tradeoff analysis—a more appropriate alternative to traditional cost-benefit analysis and one that satisfies the need for well-grounded public policy decision making. This paper will argue that the precautionary approach is the most appropriate basis for policy, even when large uncertainties do not exist, especially where the fairness of the distributions of costs and benefits of hazardous activities and products are a concern. Furthermore, it will offer an approach to making decisions within an analytic framework, based on equity and justice, to replace the economic paradigm of utilitarian cost-benefit analysis. 相似文献
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