共查询到20条相似文献,搜索用时 15 毫秒
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Highlights? Smad-interacting protein 1 (SIP1) regulates hESC differentiation ? SIP1 upregulation promotes neuroectodermal differentiation ? SIP1 inhibits mesendodermal and endodermal differentiation ? SMAD2/3 and NANOG/OCT4/SOX2 cooperatively regulate SIP1 expression 相似文献
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Highlights? AtBMI1A/B proteins prevent misexpression of embryonic traits in somatic cells ? PRC2 and AtBMI1A/B proteins maintain cells in their differentiated state ? AtBMI1A/B proteins mediate H2A monoubiquitination 相似文献
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Nikki Charles Tatsuya Ozawa Massimo Squatrito Anne-Marie Bleau Cameron W. Brennan Dolores Hambardzumyan Eric C. Holland 《Cell Stem Cell》2010,6(2):141-152
Highlights? Perivascular niche nitric oxide activates Notch in PDGF-induced gliomas ? Notch signaling drives tumor stem-like characteristics and reduces survival ? Loss of eNOS activity decreases tumor stem-like characteristics ? Suppressing eNOS activity prolongs survival in glioma-bearing mice 相似文献
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Hume Stroud Maxim V.C. Greenberg Suhua Feng Yana V. Bernatavichute Steven E. Jacobsen 《Cell》2013,152(1-2):352-364
Highlights? Genome-wide single-nucleotide resolution methylation maps in 86 silencing mutants ? Complex interplays between different DNA methylation pathways ? Identification of novel regulators of DNA methylation 相似文献
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Adkar BV Tripathi A Sahoo A Bajaj K Goswami D Chakrabarti P Swarnkar MK Gokhale RS Varadarajan R 《Structure (London, England : 1993)》2012,20(2):371-381
Highlights? Individual mutant phenotypes in a saturation library derived via deep sequencing ? Residue depth and active-site residue derivation from mutant phenotypes ? Mutant-phenotype-derived parameters used for protein model discrimination ? Derivation of sequence-structure-function relationships without protein isolation 相似文献
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Bjørn Dalhus Line Nilsen Hanne Korvald Joy Huffman Rune Johansen Forstrøm Cynthia T. McMurray Ingrun Alseth John A. Tainer Magnar Bjørås 《Structure (London, England : 1993)》2013,21(1):154-166
Highlights? Unflipped AP site stabilized by helix-hairpin-helix DNA glycosylase homolog Mag2 ? Nonenzymatic AP site recognition and DNA sculpting ? Sculpting of DNA conformation enhances substrate transfer between proteins 相似文献
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Heidi Hehnly Chun-Ting Chen Christine M. Powers Hui-Lin Liu Stephen Doxsey 《Current biology : CB》2012,22(20):1944-1950
Highlights? Endosome-proteins localize to centrosomes independent of membranes ? Rab11 and its modulators localize to mother centriole appendages ? Mother centriole appendages regulate membrane recycling through Rab11 相似文献
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Dahai Luo Andrew Kohlway Adriana Vela Anna Marie Pyle 《Structure (London, England : 1993)》2012,20(11):1983-1988
Highlights? Crystallographic structure of RIG-I with 5′ triphosphorylated RNA duplex and ADP ? Solution biophysical analysis of ATP-dependent RIG-I conformational change ? The structural basis for ATP-stimulated RIG-I activation 相似文献
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Highlights? Drosophila Matrix Metalloprotease (Mmp) inhibits FGF signaling ? An FGF – MMP feedback loop regulates branching morphogenesis ? Mmp2 spatially regulates FGF signaling in epithelia 相似文献
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Kushol Gupta Joseph E. Curtis Susan Krueger Young Hwang Peter Cherepanov Frederic D. Bushman Gregory D. Van Duyne 《Structure (London, England : 1993)》2012,20(11):1918-1928
Highlights? Missing domains in PFV intasome revealed by SAXS/SANS ? PFV IN undergoes dramatic changes in conformation and oligomerization upon binding DNA ? Strand transfer inhibitors do not alter quaternary structure of PFV intasome 相似文献
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Fabian Anton Gunnar Dittmar Thomas Langer Mafalda Escobar-Henriques 《Molecular cell》2013,49(3):487-498
Highlights? Mitochondrial fusion is regulated by independent ubiquitylation pathways ? The deubiquitylase Ubp2 promotes fusion, whereas Ubp12 inhibits fusion events ? Self-assembly and ubiquitylation cooperatively enable mitochondrial fusion ? Yeast mitofusin is sequentially ubiquitylated 相似文献
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Nathan F. Putman Kenneth J. Lohmann Emily M. Putman Thomas P. Quinn A. Peter Klimley David L.G. Noakes 《Current biology : CB》2013,23(4):312-316
Highlights? Sockeye salmon use geomagnetic imprinting as a homing mechanism ? The homing route of salmon is predicted by magnetic field drift (secular variation) 相似文献
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Daniel J. Bumbarger Metta Riebesell Christian Rödelsperger Ralf J. Sommer 《Cell》2013,152(1-2):109-119
Highlights? Massive neural circuit rewiring between nematodes with divergent feeding behavior ? Striking patterns correlate with known functional differences ? Motor synapse differences indicate a substantial change in information flow ? Correlates of predatory feeding behavior are identified 相似文献
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John-Stuart Brittain Penny Probert-Smith Tipu Z. Aziz Peter Brown 《Current biology : CB》2013,23(5):436-440
Highlights? Phase-cancelling cortical stimulation attenuates Parkinsonian tremor ? Prolonged stimulation may invoke adaptive mechanisms ? Phase cancellation may provide a generic treatment approach to oscillopathies ? TACS provides a convenient probe of cortical circuit dynamics in humans 相似文献
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Highlights? Not all hepatocytes undergo cell division during liver regeneration ? Hypertrophy precedes proliferation in the regenerating liver ? Hepatocytes infrequently enter into M phase during liver regeneration ? Binuclear hepatocytes undergo cell division to generate mononuclear hepatocytes 相似文献
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Highlights? Discovery that Rspo3 binds syndecan 4 ? Rspo3/Sdc4 induce Wnt/PCP signaling via clathrin-mediated endocytosis ? Rspo3/PCP signaling is essential for gastrulation and cartilage morphogenesis 相似文献
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MTR1 encodes a secretory fasciclin glycoprotein required for male reproductive development in rice 总被引:1,自引:0,他引:1
Highlights? The fasciclin glycoprotein MTR1 regulates male reproductive development in rice ? Rice male reproductive cells secrete MTR1 to control somatic tapetum development 相似文献
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Changmei Liu Zhao-Qian Teng Nicholas J. Santistevan Keith E. Szulwach Weixiang Guo Peng Jin Xinyu Zhao 《Cell Stem Cell》2010,6(5):433-444
Highlights? MBD1 governs the proliferation and differentiation of neural stem cells (NSCs) ? MBD1 controls the expression of miRNAs, including miR-184, in NSCs ? MiR-184 represses the expression of Numblike ? Numblike rescues the effects of abnormal MBD1 and miR-184 expression 相似文献