共查询到9条相似文献,搜索用时 0 毫秒
1.
2.
3.
4.
5.
6.
7.
The paired helical filament (PHF), which comprises the major fibrous element of the neurofibrillary tangle of Alzheimer's disease, is composed of abnormally phosphorylated microtubule-associated protein tau. Here we show that p42 MAP kinase phosphorylates recombinant tau and converts it to a form which is similar to PHF tau. Of the major serine/threonine protein phosphatases found in mammalian tissues only protein phosphatase 2A (PP2A) could dephosphorylate tau phosphorylated in this manner, with PP2A1 being the most effective form of the enzyme. 相似文献
8.
Varshochi R Halim F Sunters A Alao JP Madureira PA Hart SM Ali S Vigushin DM Coombes RC Lam EW 《The Journal of biological chemistry》2005,280(5):3185-3196
9.
Coss D Hand CM Yaphockun KK Ely HA Mellon PL 《Molecular endocrinology (Baltimore, Md.)》2007,21(12):3071-3086