共查询到20条相似文献,搜索用时 31 毫秒
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The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity 总被引:6,自引:0,他引:6
Dubreuil V Hirsch MR Pattyn A Brunet JF Goridis C 《Development (Cambridge, England)》2000,127(23):5191-5201
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During differentiation of sympathetic neurons in chick embryos, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) mRNAs become detectable during the same developmental period and are both induced by BMP 4. Later during sympathetic ganglion development, DBH is detectable in TH-positive and -negative cells. Moreover, BMPs reduce DBH mRNA in cultures of sympathetic neurons while leaving TH unaffected. The data provide evidence for a common regulation of TH and DBH early during sympathetic neuron differentiation and indicate that BMPs promote their initial expression but not the maintenance during later development. The time course of Phox2a and 2b expression suggests an evolutionary conserved role in noradrenergic induction. In addition, Phox2a, Phox2b, and c-ret may be involved in the differentiation of cholinergic sympathetic neurons. 相似文献
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Phox2 genes - from patterning to connectivity 总被引:6,自引:0,他引:6
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Gata3 participates in a complex transcriptional feedback network to regulate sympathoadrenal differentiation 总被引:7,自引:0,他引:7
Moriguchi T Takako N Hamada M Maeda A Fujioka Y Kuroha T Huber RE Hasegawa SL Rao A Yamamoto M Takahashi S Lim KC Engel JD 《Development (Cambridge, England)》2006,133(19):3871-3881
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