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Retinobenzoic acids and nuclear retinoic acid receptors. 总被引:4,自引:0,他引:4
Y Hashimoto 《Cell structure and function》1991,16(2):113-123
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Julius Brtko Peter Filipčík Soňa Hudecová Anastázia Brtková Janette Bransová 《Biological trace element research》1998,62(1-2):43-50
The present study was undertaken to investigate the effects of selenite (SeIV) and selenate (SeVI) on the all-trans retinoic acid (RA)-nuclear retinoic acid receptor (RAR) complex formation in rat liver. We also present
the data on the in vitro effects of SeIV on the RARα and the type I iodothyronine 5′-deiodinase gene expression in the GH4C1 rat pituitary tumor cells. SeIV at 1.0 μmol/L was found to reduce (p<0.05) the RA specific binding to RAR in rat liver. Dithiothreitol (DTT), a protective agent for sulfhydryl groups, was found
to be slightly effective in protecting the RAR binding properties when affected by SeIV. SeVI at 0.1 μmol/L reduced (p<0.05) the RA specific binding to RAR in liver, as well. Seleno-l-methionine (Se-II) when compared tol-methionine did not exert any inhibitory effect on the formation of the RA-RAR complex. SeIV (up to 2.5 μmol/L) has no inhibitory effect on GH4C1 cell proliferation as well as the prolactin secretion. SeIV at 1.0 μmol/L significantly decreases the rate of mRNA synthesis and/or degradation of the α form of the RAR and causes the
enhancement of the type I iodothyronine 5′-deiodinase gene expression in GH4C1 cells.
The results based on in vitro experiments suggest that inorganic selenium may affect the RA specific binding to their cognate
receptor molecules, and it may reduce expression of the gene encoding the RARα, with the cell vitality and the cell growth
remaining unchanged. 相似文献
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RXR-dependent and RXR-independent transactivation by retinoic acid receptors. 总被引:3,自引:0,他引:3 下载免费PDF全文
M Schrder A Wyss L J Sturzenbecker J F Grippo P LeMotte C Carlberg 《Nucleic acids research》1993,21(5):1231-1237
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R Shimazawa R Sanda H Mizoguchi Y Hashimoto S Iwasaki H Tanaka H Kagechika K Shudo 《Biochemical and biophysical research communications》1991,179(1):259-265
A fluorescent probe for retinoid receptors (RARs) was designed and prepared. The probe consists of a retinoid moiety and a dansyl moiety, i.e., 2-[3-(5-dimethylaminonaphthalene-1-sulfonyl)- aminopropyl-1-oxy]-4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2- naphthalenyl)carboxamido]benzoic acid: DAM-3. DAM-3 specifically bound RARs. Additionally, a photoreactive RAR fluorescent probe was designed and prepared, i.e., 2-[3-(5-azidonaphthalene- 1-sulfonyl)aminopropyl-1-oxy]-4-[(5,6,7,8-tetrahydro-5,5,8,8- tetramethyl-2-naphthalenyl)carboxamido]benzoic acid (ADAM-3). ADAM-3 irreversibly and specifically bound RARs using ultraviolet irradiation. 相似文献
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Interest in retinoids and craniofacial development originated independently from nutritional and teratological studies; however, the site of action of retinoids in normal development remains contentious. Recent transgenic strategies have shown that retinoic acid and nuclear retinoid receptors are required for the morphogenetic specification of cranial neural crest cells and their mesenchymal derivatives during craniofacial development. Interestingly, while some aspects of the RA teratogenicity have been shown to be receptor-mediated, there is as yet no clear evidence that this is the case for the embryonic head and face. Hox genes are one important set of targets for RA in the developing neural primordium and cranial neural crest, but it remains unclear as to how retinoid-mediated regulation of such targets is realized as the morphogenetic specification of cell fate. 相似文献
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David Lohnes Manuel Mark Cathy Mendelsohn Pascal Doll Didier Decimo Marianne LeMeur Andre Dierich Philippe Gorry Pierre Chambon 《The Journal of steroid biochemistry and molecular biology》1995,53(1-6):475-486
Retinoic acid, one of the principle active metabolites of vitamin A (retinol), is believed to be essential for numerous developmental and physiological processes. Vitamin A deprivation (VAD) during development leads to numerous congenital defects. Previous studies of retinoic acid receptor (RAR) deficient mice failed to reveal any of these VAD-induced defects. This finding suggested that either the RARs are functionally redundant or that they are not critically required during development. In order to address these possibilities, we derived a number of RAR compound mutants. Unlike RAR single mutants, these compound null mutants died either in utero or shortly following birth. Histological analysis revealed essentially all of the defects characteristic of fetal VAD. A number of additional malformations, not described in previous VAD studies, were also observed. These included defects of the ocular and salivary glands and their ducts, the skeletal elements of the fore-and hindlimbs, and the cervical region of the axial skeleton. In addition, with the exception of derivatives forming within the first pharyngeal arch, most of the elements derived from mesectoderm emanating from cranial and hindbrain levels were affected. A number of these mutants also exhibited supernumerary cranial skeletal elements characteristics of the reptilian skull. A summary of the defects found in these RAR double mutants is presented. 相似文献
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COUP orphan receptors are negative regulators of retinoic acid response pathways. 总被引:13,自引:11,他引:13 下载免费PDF全文
P Tran X K Zhang G Salbert T Hermann J M Lehmann M Pfahl 《Molecular and cellular biology》1992,12(10):4666-4676