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F Cárdenas A Plancarte H Quiroz M T Rabiela A Gómez-Leal D Correa A Flisser 《Experimental parasitology》1989,69(4):324-329
An experimental model of Taenia crassiceps intraocular cysticercosis was developed in rabbits. The objectives of this study were to analyze the pathophysiology of this parasitic infection and to evaluate the humoral immune response. Cysticerci, inoculated in the anterior chamber of the eye, were able to grow; no inflammatory changes in the eye or anticysticercus antibodies in serum or in aqueous humor were detected during the 12-day period. In contrast, rabbits that had previously been either infected intraperitoneally with living T. crassiceps cysts or immunized intramuscularly with T. crassiceps antigenic extract developed an intense inflammatory reaction in the eye and high levels of antibodies were detected in serum and aqueous humor even before the intraocular inoculation of parasites. Furthermore, intraocular cysticerci showed minimal growth and some were eliminated. These findings support the concept that the eye is an immunologically privileged site in the nonimmunized host and the importance of the immune response in the elimination of this parasitic infection. 相似文献
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Kashi Nath Prasad Amit Prasad Avantika Verma Aloukick Kumar Singh 《Journal of biosciences》2008,33(4):571-582
Cysticercosis, caused by Taenia solium larva is a major public health problem, especially in the developing world and neurocysticercosis (NCC) is considered to
be the most common parasitic infestation of the central nervous system. NCC is identified as the single most common cause
of community acquired active epilepsy; 26.3% to 53.8% active epilepsy cases in the developing world including India and Latin
America are due to NCC. It is also becoming more common in the developed world because of increased migration of people with
the disease or Taenia solium carriers and frequent travel to the endemic countries. It is estimated that three quarters of the estimated 50 million people
with active epilepsy live in the poor countries of the world. Recent Indian studies using neuroimaging techniques suggest
that the disease burden in India surpasses many other developing countries. Hence it is important to know the epidemiology,
pathogenesis and diagnostic criteria so as to assess the disease burden and adopt interventional strategies for its control.
Literature search was done for this review with special emphasis on Indian studies to create awareness about the disease in
India, since cysticercosis is preventable and potentially eradicable. 相似文献
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H. W. Riggs 《CMAJ》1923,13(2):106-108
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