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1.
Yumi Moriwake Yoshiyuki Tohno Setsuko Tohno Takeshi Minami Masako Utsumi Fumio Nishiwaki Masa-oki Yamada Hiroshi Yamamoto Yuko Okazaki Tadashi Fujii Yoshinori Takakura 《Biological trace element research》1998,64(1-3):229-235
The relative contents (RCs) of elements in the human menisci from 23 subjects in the age range between 65 and 93 yr were analyzed
by inductively coupled plasma atomic emission spectrometry. The RCs of sulfur, calcium, and phosphorus in menisci increased
progressively until the 80s, being the highest in the 80s, and thereafter decreased. The RCs of magnesium in menisci increased
progressively until the 90s. Regarding the medial and lateral menisci, higher RCs of magnesium and iron, and a lower RC of
phosphorus were found in lateral menisci in comparison with those in medial menisci.
There were sexual differences in the RCs of calcium and phosphorus of medial and lateral menisci. The RCs of calcium and phosphorus
were about 50% higher in women’s menisci than in men’s. Histological examinations showed that structureless mucoid masses
were observed in the menisci, with very high RCs of calcium and phosphorus being detected. 相似文献
2.
Moriwake Y Tohno Y Tohno S Azuma C Minami T Takano Y 《Biological trace element research》2002,88(3):215-222
To elucidate compositional changes of elements in the meniscus with aging, the authors investigated the relationships among
elements in the medial meniscus by inductively coupled plasma-atomic emission spectrometry. The subjects consisted of 16 men
and 7 women, ranging in age from 65 to 93 yr. In the left medial meniscus, extremely significant correlations were found both
between calcium and phosphorus contents and between sulfur and magnesium contents, whereas significant correlations were found
between calcium and either iron or zinc contents, between phosphorus and either iron or zinc contents, and between iron and
zinc contents. On the other hand, in the right medial meniscus, there were only an extremely significant correlation between
calcium and phosphorus contents and a significant correlation between sulfur and magnesium contents. The common finding between
the left and right medial menisci was an extremely significant correlation between calcium and phosphorus contents and a significant
correlation between sulfur and magnesium contents. 相似文献
3.
Tohno Y Tohno S Azuma C Moriwake Y Naganuma T Ohnishi Y Minami T 《Biological trace element research》2003,96(1-3):93-107
To elucidate compositional changes of the thoracic duct with aging, the authors investigated age-related changes of elements
in the thoracic ducts in comparison with the azygos veins. The subjects consisted of 22 men and 1 woman, ranging in age from
65 to 95 yr. After ordinary dissection, the thoracic ducts and azygos veins were resected from the subjects and element contents
were determined by inductively coupled plasma-atomic emission spectrometry. It was found that calcium appeared to increase
in the thoracic duct with aging, but the other elements, such as phosphorus, sulfur, magnesium, iron, zinc, and sodium, did
not change significantly with aging. In the azygos vein, both calcium and sulfur increased significantly with aging.
Regarding the relationship among elements, extremely significant direct correlations were found among calcium, phosphorus,
sulfur, and magnesium in the thoracic ducts, except for phosphorus and magnesium contents with a very significant direct correlation.
In the azygos veins, significant direct correlations were found between calcium and sulfur contents and between sulfur and
magnesium contents. However, no significant correlations were found among calcium, phosphorus, and magnesium in the azygos
veins. These results revealed that with regard to the relationship among calcium, phosphorus, and magnesium, the thoracic
duct was similar to the arteries, but not to the azygos vein. 相似文献
4.
Articular calcification correlates with osteoarthritis (OA) severity but its exact role in the disease process is unclear.
In examining OA meniscal cell function, Sun and colleagues have shown recently that meniscal cells from end-stage OA subjects
can generate calcium crystals and that genes involved in calcification are upregulated in OA meniscal cells. Also, this in vitro calcium deposition by OA menisci is inhibited by phosphocitrate. This study should catalyse further work examining the pathological
contribution or otherwise of calcium crystals in OA. This would significantly aid the development of potential disease modifying
agents in OA, which are currently unavailable. 相似文献
5.
Yoshida S Takano Y Moriwake Y Tohno Y Masuda M Tohno S Minami T Yamasaki M Morikawa H Yuri K 《Biological trace element research》2001,80(1):13-22
To elucidate compositional changes of the uterine tube by aging, the authors studied age-related changes of elements in human uterine tubes by inductively coupled plasma-atomic emission spectrometry. The uterine tubes were resected postmortem or surgically removed from patients with uterine myoma. It was found that the contents of calcium and magnesium increased progressively with aging in uterine tubes, whereas the contents of phosphorus and iron decreased gradually with aging. The sulfur content of uterine tubes remained constant and independent of aging. Regarding relationships between elements, significant relationships were found between calcium and magnesium contents, between phosphorus and iron contents, between phosphorus and sulfur contents, and between phosphorus and sodium contents in human uterine tubes. 相似文献
6.
Yoshiyuki Tohno Setsuko Tohno Yumi Moriwake Cho Azuma Yoshiaki Ohnishi Takeshi Minami 《Biological trace element research》2001,82(1-3):21-28
To elucidate compositional changes of the arteries with aging, the authors investigated the relationships among average contents
of calcium, phosphorus, sulfur, and magnesium in the arteries by inductively coupled plasma-atomic emission spectrometry.
The arteries used were the thoracic and abdominal aortas, coronary, common carotid, anterior, middle and posterior cerebral,
vertebral, basilar, internal thoracic, axillary, radial, truncus celiacus, common, internal and external iliac, femoral, popliteal,
and umbilical arteries. It was found that high correlations were found between the average contents of calcium and phosphorus,
between the average contents of calcium and magnesium, and between the average contents of phosphorus and magnesium in the
arteries, but not between the average contents of sulfur and the other elements. These correlations revealed that as the content
of calcium and phosphorus increased in the arteries, the magnesium content increased simultaneously in the arteries, but the
sulfur content did not. It is likely that magnesium forms compounds with phosphorus in the arteries. 相似文献
7.
Yoshiyuki Tohno Setsuko Tohno Yumi Moriwake Cho Azuma Yoshiaki Ohnishi Takeshi Minami 《Biological trace element research》2001,82(1-3):9-19
To elucidate the accumulation of elements in the arteries with aging, the authors investigated age-related changes of elements
in human arteries, such as the thoracic aorta, femoral, basilar, coronary, radial, and common iliac arteries by inductively
coupled plasma-atomic emission spectrometry. The subjects consisted of 17 men and 9 women, ranging in age from 55 to 92 yr
in the cases of the five arteries, except for the common iliac arteries, in which the subjects consisted of 16 men and 8 women,
ranging in age from 65 to 93 yr.
It was found that there were significantly direct correlations between calcium and phosphorus contents and between calcium
and magnesium contents in all of the six arteries: thoracic aorta, femoral, basilar, coronary, radial, and common iliac arteries.
Significantly direct correlations were also found between phosphorus and magnesium contents in the five arteries, except for
the basilar artery. In contrast, significantly inverse correlations were found between calcium and sulfur contents and between
phosphorus and sulfur contents in the four arteries, except for the coronary and radial arteries. These revealed that the
accumulation of calcium and phosphorus in the arteries was accompanied by an increase of magnesium in the arteries and by
a decrease of sulfur in the arteries. 相似文献
8.
Age-related changes of elements in the human articular disk of the temporomandibular joint 总被引:2,自引:0,他引:2
Takano Y Moriwake Y Tohno Y Minami T Tohno S Utsumi M Yamada M Okazaki Y Yamamoto K 《Biological trace element research》1999,67(3):269-276
To elucidate compositional changes of the articular disk (AD) of the temporomandibular joint (TMJ) by aging, elements of the
ADs resected from 18 cadavers were determined by inductively coupled plasma atomic-emission spectrometry. It was found that
calcium contents of ADs in TMJs increased progressively with aging, whereas the sulfur contents of the ADs decreased slightly
with aging. Regarding the content of phosphorus, the contents increased progressively with aging. The study revealed that
age-related changes of calcium contents in the ADs of TMJs were similar to those in women’s pubic symphyses, but not those
in intervertebral disks and menisci. 相似文献
9.
Azuma C Tohno S Mahakkanukrauh P Tohno Y Ongkana N Minami T Moriwake Y Kumai T Vaidhayakarn P Yamada MO Maruyama H 《Biological trace element research》2005,105(1-3):59-70
To elucidate compositional changes of the elastic cartilage with aging, the authors investigated age-related changes of elements
in the epiglottal cartilages by inductively coupled plasma-atomic emission spectrometry. After the ordinary dissection by
medical students at Chiang Mai University was finished, the epiglottises were resected from the subjects. The epiglottal cartilages
were isolated and the element contents were determined. The subjects consisted of 11 men and 14 women, ranging in age from
39 to 92 yr old. It was found that although the extent of accumulation of calcium and phosphorus was slight, calcium and phosphorus
increased progressively in the epiglottal cartilages with aging. In contrast, sulfur, magnesium, zinc, iron and sodium did
not change significantly in them. Regarding the relationships among elements, it was found that there were significant correlations
among calcium, phosphorus, magnesium, and sodium in the epiglottal cartilages, with one exception between calcium and sodium
contents. In comparison between men and women, no significant differences were found in the predominant elements such as calcium,
sulfur, and phosphorus in the epiglottal cartilages. 相似文献
10.
Yubo Sun David R Mauerhan Patrick R Honeycutt Jeffrey S Kneisl H James Norton Natalia Zinchenko Edward N HanleyJr Helen E Gruber 《Arthritis research & therapy》2010,12(2):R56
Introduction
Calcium crystals exist in the knee joint fluid of up to 65% of osteoarthritis (OA) patients and the presence of these calcium crystals correlates with the radiographic evidence of hyaline cartilaginous degeneration. This study sought to examine calcium deposition in OA meniscus and to investigate OA meniscal cell-mediated calcium deposition. The hypothesis was that OA meniscal cells may play a role in pathological meniscal calcification. 相似文献11.
Yoshiyuki Tohno Setsuko Tohno Takeshi Minami Masayo Ichii Yoko Okazaki Masako Utsumi Fumio Nishiwaki Yumi Moriwake Masa-oki Yamada Tsutomu Araki 《Biological trace element research》1996,54(1):23-31
The relative contents (RCs) of mineral elements in aortae and cerebral arteries from 23 subjects, with ages ranging between
45 and 99 yr, were analyzed by inductively coupled plasma atomic emission spectrometry. The RCs of calcium, phosphorus, and
magnesium in the aortae increased markedly after the age of 70. While the RC of sulfur in aortae decreased gradually after
that age. It was found that accumulation of calcium and phosphorus occurred primarily in the tunica media of aorta, and secondarily
in the tunica intima. Furthermore, the RCs of calcium, phosphorus, and magnesium in cerebral arteries increased markedly after
the age of 70, whereas the RC of sulfur in cerebral arteries decreased after age 70. It was found that accumulation of calcium
and phosphorus in the cerebral arteries were 30 and 60%, respectively, lower than those in the aortae with ages ranging between
45 and 99 yr. 相似文献
12.
Takano Y Tohno Y Moriwake Y Tohno S Minami T Yamada MO Yuri K 《Biological trace element research》2000,74(2):117-125
To elucidate changes of the ureter with aging, the authors investigated age-related changes of element contents in human ureters.
The subjects consisted of seven men and seven women, ranging in age from 61 to 97 yr. The contents of calcium, sulfur, and
iron in the ureters increased progressively with aging, whereas the contents of phosphorus and magnesium did not increase
with aging. Significant relationships were found both between calcium and sulfur contents and between calcium and iron contents
in the ureters, but not between calcium and either phosphorus or magnesium contents. It was noteworthy that a significant
relationship was also found between sulfur and iron contents in the ureters. It remains uncertain whether calcium forms a
compound with sulfur or iron in aged human ureters or not. 相似文献
13.
Mahakkanukrauh P Tohno S Tohno Y Chomsung R Azuma C Moriwake Y Minami T 《Biological trace element research》2004,100(3):205-214
To examine whether there were differences between races in regard to the relationships among element contents in the arteries,
the authors investigated the relationships among the average contents of calcium, phosphorus, sulfur, and magnesium in the
18 kinds of the Thai artery. After ordinary dissection by medical students at Chiang Mai University was finished, the thoracic
and abdominal aortas, ramifying site of the abdominal aorta into the common iliac arteries, coronary, common carotid, internal
thoracic, subclavian, axillary, brachial, radial, superior and inferior mesenteric, renal, common iliac, internal iliac, and
external iliac arteries were resected from the subjects who consisted of 12 men and 3 women, ranging in age from 39 to 84
yr. The femoral and posterior tibial arteries were resected from the subjects, consisting of 15 men and 5 women, ranging in
age from 25 to 88 yr. The element content of the arteries was analyzed by inductively coupled plasma-atomic emission spectrometry.
It was found that there were extremely significant direct correlations among the average contents of calcium, phosphorus,
and magnesium in the 18 kinds of the Thai artery, but no significant correlations were found between the average contents
of sulfur and elements, such as calcium, phosphorus, and magnesium. These results were in agreement with those of the Japanese
arteries. Therefore, it was suggested that there was no significant difference between the arteries of the Thai and the Japanese
in the relationships among calcium, phosphorus, sulfur, and magnesium. 相似文献
14.
Norikazu Matsumoto Tsukasa Kumai Shinji Isomoto Yasushi Shinohara Yasuhito Tanaka Cho Azuma Takeshi Minami Yoshiyuki Tohno 《Biological trace element research》2013,154(2):185-189
Many studies have been performed on the structure, molecular composition, and biochemical properties of tendons. However, comparatively little research has been conducted on the content of various trace elements within tendons. Six elements were analyzed in four regions of the peroneus longus tendon: the tensional part of the tendon immediately proximal to the lateral malleolus (region A), the compressive region of the tendon in contact with the lateral malleolus (region B), the compressive region of the tendon in contact with the deep surface of the cuboid (region C), and the tensional part of the tendon between the cuboid and first metatarsal, to which the tendon is attached (region D). Regions B and C are wraparound regions. The calcium content was higher in region C (2.10?±?0.93 mg/g) than in both regions A (1.25?±?0.51 mg/g) and D (1.43?±?0.41 mg/g) (p?<?0.05), indicating that it is likely related to regional differences in cartilage degeneration. The phosphorus content was also higher in region C, possibly because of low alkaline phosphatase activity in this region. The sulfur content was higher in the wraparound regions (region B: 0.98?±?0.09 mg/g, region C: 1.24?±?0.19 mg/g) than in both regions A (0.83?±?0.11 mg/g) and D (0.83?±?0.1 mg/g) (p?<?0.01); sulfur content is thought to be influenced by tendon–bone compression. Finally, the magnesium content in the wraparound regions was also higher, which is probably related to a higher level of fibrocartilage. No significant relationships were found with regard to zinc or iron. Overall, the findings of the present study indicate that element contents are related to function and anatomical differences in tendons, and that they may even vary within the same tendon. 相似文献
15.
Ohnishi Y Tohno S Mahakkanukrauh P Tohno Y Vaidhayakarn P Azuma C Satoh H Moriwake Y Chomsung R Minami T 《Biological trace element research》2003,96(1-3):71-92
To elucidate whether the extent of element accumulation in the arteries and cardiac valves with aging was different between
different races, the authors investigated the accumulation of elements in the arteries and cardiac valves of the Thai with
aging and the relationships among elements in the cardiac valves. After ordinary dissection at Chiang Mai University was finished,
16 arteries and 4 cardiac valves were resected and element contents were determined by inductively coupled plasma-atomic emission
spectrometry.
In the 16 arteries, the average content of calcium was the highest in the site of the abdominal aorta ramifying into the common
iliac arteries, and it decreased in the order internal iliac, coronary, abdominal aorta, common iliac, external iliac, superior
mesenteric, inferior mesenteric, thoracic aorta, brachial, radial, common carotid, subclavian, ulnar, axillary, renal, and
internal thoracic arteries. The average contents of phosphorus and magnesium in respective arteries were parallel with the
average contents of calcium, except for the coronary artery. In comparison with the arteries of the Japanese, the trend of
calcium accumulation in the arteries of the Thai was almost similar to that in the arteries of the Japanese, except for the
coronary artery and thoracic aorta. The calcium accumulation in the coronary artery was much higher in the Thai than in the
Japanese, whereas that in the thoracic aorta was lower in the Thai than in the Japanese.
Regarding elements in the cardiac valves, the calcium content increased remarkably in the seventies in the aortic valve and
in the nineties in the pulmonary valve, but it hardly increased in both the mitral and tricuspid valves with aging. The average
content of calcium was the highest in the aortic valve, and it decreased in the order pulmonary, tricuspid, and mitral valves.
Regarding the relationship among elements in the aortic valves, it was found that there were extremely significant direct
correlations among the contents of calcium, phosphorus, and magnesium, whereas there were significant direct correlations
between zinc and either calcium or phosphorus contents. Although significant correlations were found between sulfur and the
other element contents in the aortic valves of the Japanese, no significant correlations were found between them in the aortic
valves of the Thai. In the mitral valves, extremely or very significant direct correlations were found among the contents
of calcium, phosphorus, magnesium, and sulfur, with some exceptions that there were no significant correlations between phosphorus
and either magnesium or sulfur contents.
In addition, no significant correlation was found in the calcium content between the aortic valve and coronary artery in the
same individuals. 相似文献
16.
Tohno S Tohno Y Minami T Moriwake Y Azuma C Ohnishi Y 《Biological trace element research》2002,86(1):23-30
To elucidate the manner of element accumulation in the arteries with aging, the authors investigated the element contents
in the calcified and surrounding sites of the thoracic aortas by inductively coupled plasma-atomic emission spectrometry.
The subjects consisted of three men and five women, ranging in age from 45 to 99 yr. The calcified, calcification-surrounding,
and control (which appeared normal) sites were removed from the thoracic aortas and the element contents were determined.
It was found that the contents of calcium, phosphorus, magnesium, zinc, and aluminum were higher in the calcified site than
in the control site, whereas the contents of sulfur, iron, and lead were lower in the calcified site than in the control site.
The contents of the elements in the surrounding site were intermediate between those of the calcified and control sites, except
for the magnesium and lead contents, which were the lowest.
The mass ratios of magnesium to calcium and phosphorus were lower in the calcified site compared with the surrounding and
control sites, and as calcium and phosphorus increased in the aorta, the mass ratios lowered gradually in the aorta. 相似文献
17.
Mycological Applications of X-Ray Microanalysis 总被引:1,自引:0,他引:1
In Aspergillus fumigatus, X-ray microanalysis applied in wavelength dispersive spectroscopy enabled us to detect the presence of calcium, potassium, sulfur, phosphorus, and magnesium; and in A. niger we detected the presence of calcium, potassium, chloride, sulfur, phosphorus, sodium, and magnesium. These various elements were identified by their K alpha lines. 相似文献
18.
Tohno S Tohno Y Moriwake Y Azuma C Ohnishi Y Minami T 《Biological trace element research》2001,84(1-3):57-66
To elucidate the mechanism of element accumulations in the arteries with aging, the authors investigated the mass ratios among
calcium, phosphorus, and magnesium in the common iliac arteries by inductively coupled plasma-atomic emission spectrometry.
The subjects consisted of 16 men and 8 women, ranging in age from 65 to 93 yr.
It was found that there were extremely significant correlations between calcium and phosphorus contents, between calcium and
magnesium contents, and between phosphorus and magnesium contents in the common iliac arteries. In regard to the mass ratio,
although the mass ratio of calcium to phosphorus was almost constant, the mass ratios of magnesium to calcium and phosphorus
were different at early and advanced stages of the accumulation of calcium and phosphorus. It was found that both the mass
ratios of magnesium to calcium and phosphorus were higher at an early stage of the accumulation of calcium and phosphorus
in the arteries than at an advanced stage of the accumulation. 相似文献
19.
Tohno S Tohno Y Moriwake Y Azuma C Ohnishi Y Minami T 《Biological trace element research》2002,87(1-3):83-93
To elucidate compositional changes of the cardiac valves with aging, the authors investigated the relationships among element
contents in the aortic valves, in which the accumulation of calcium and phosphorus was the highest. The subjects consisted
of 10 men and 14 women, ranging in age from 65 to 102 yr. Extremely significant direct correlations were found among the contents
of calcium, phosphorus, magnesium, sodium, and zinc in the aortic valves. In contrast, significant inverse correlations were
found between the contents of sulfur and the other elements, such as calcium, phosphorus, magnesium, and sodium. It should
be noted that these correlations present in the aortic valves were very similar to those in the arteries, especially those
in the thoracic aortas. The changes of the mass ratios of Mg/Ca and Mg/P in the aortic valves were similar to those in the
thoracic aortas. As calcium and phosphorus increased in the aortic valve, the mass ratios Mg/Ca and Mg/P decreased reversely
in the aortic valve. These results suggest that the compositional change of the aortic valve is very similar to that of the
thoracic aorta. 相似文献
20.
Tohno Y Tohno S Minami T Moriwake Y Nishiwaki F Hashimoto K Yamamoto H 《Biological trace element research》2000,77(2):107-118
To elucidate changes of human cardiac valves with aging, the authors determined age-related changes of element contents in
the four human cardiac valves by inductively coupled plasma-atomic emission spectrometry and attempted to examine the relationships
in the element contents among the four cardiac valves. The subjects consisted of 10 men and 15 women, ranging in age from
65 to 102 yr. The accumulation of calcium and phosphorus was the highest in the aortic valve, and decreased in the order mitral,
pulmonary, and tricuspid valves. The contents of calcium and phosphorus in the aortic valves corresponded to about 12 and
19 times the amounts of those in the tricuspid valves, in which the contents were very low. The contents of calcium and phosphorus
in the aortic valves were about 2.5-fold the amounts of those in the mitral valves.
An examination was attempted to determine whether or not there were relationships in element contents among the four cardiac
valves. As for the aortic and mitral valves, there were no relationships in the contents of calcium and phosphorus between
them, but there were relationships in the contents of sulfur and magnesium between them. Three out of 24 cases contained high
contents of calcium and phosphorus in both the mitral and aortic valves, whereas 16 out of 24 cases contained high contents
of calcium and phosphorus in the aortic valves alone, without the high contents in the mitral valves. Likewise, there were
no relationships in the element contents, such as calcium, phosphorus, sulfur, and magnesium, between the mitral and pulmonary
valves or between the mitral and tricuspid valves. It is suggested that the accumulation of calcium and phosphorus in the
cardiac valve occurs independent of the other cardiac valves. 相似文献