共查询到20条相似文献,搜索用时 78 毫秒
1.
2.
3.
Maf transcriptionally activates the mouse p53 promoter and causes a p53-dependent cell death 总被引:6,自引:0,他引:6
Hale TK Myers C Maitra R Kolzau T Nishizawa M Braithwaite AW 《The Journal of biological chemistry》2000,275(24):17991-17999
4.
5.
Opposite role of yeast ING family members in p53-dependent transcriptional activation 总被引:8,自引:0,他引:8
Nourani A Howe L Pray-Grant MG Workman JL Grant PA Côté J 《The Journal of biological chemistry》2003,278(21):19171-19175
6.
7.
Transcriptional activation of p53 by Pitx1 总被引:1,自引:0,他引:1
8.
ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation 总被引:1,自引:0,他引:1
下载免费PDF全文
![点击此处可从《Molecular and cellular biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Pedeux R Sengupta S Shen JC Demidov ON Saito S Onogi H Kumamoto K Wincovitch S Garfield SH McMenamin M Nagashima M Grossman SR Appella E Harris CC 《Molecular and cellular biology》2005,25(15):6639-6648
ING2 is a candidate tumor suppressor gene that can activate p53 by enhancing its acetylation. Here, we demonstrate that ING2 is also involved in p53-mediated replicative senescence. ING2 protein expression increased in late-passage human primary cells, and it colocalizes with serine 15-phosphorylated p53. ING2 and p53 also complexed with the histone acetyltransferase p300. ING2 enhanced the interaction between p53 and p300 and acted as a cofactor for p300-mediated p53 acetylation. The level of ING2 expression directly modulated the onset of replicative senescence. While overexpression of ING2 induced senescence in young fibroblasts in a p53-dependent manner, expression of ING2 small interfering RNA delayed the onset of senescence. Hence, ING2 can act as a cofactor of p300 for p53 acetylation and thereby plays a positive regulatory role during p53-mediated replicative senescence. 相似文献
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.