共查询到20条相似文献,搜索用时 31 毫秒
1.
Background
The proteomics literature has seen a proliferation of publications that seek to apply the rapidly improving technology of 2D gels to study various biological systems. However, there is a dearth of systematic studies that have investigated appropriate statistical approaches to analyse the data from these experiments. 相似文献2.
Ignacio Marín 《BMC evolutionary biology》2009,9(1):267
Background
Cullins are proteins involved in ubiquitination through their participation in multisubunit ubiquitin ligase complexes. In this study, I use comparative genomic data to establish the pattern of emergence and diversification of cullins in eukaryotes. 相似文献3.
Maciej Paszkowski-Rogacz Mikolaj Slabicki M Teresa Pisabarro Frank Buchholz 《BMC bioinformatics》2010,11(1):254
Background
With the current technological advances in high-throughput biology, the necessity to develop tools that help to analyse the massive amount of data being generated is evident. A powerful method of inspecting large-scale data sets is gene set enrichment analysis (GSEA) and investigation of protein structural features can guide determining the function of individual genes. However, a convenient tool that combines these two features to aid in high-throughput data analysis has not been developed yet. In order to fill this niche, we developed the user-friendly, web-based application, PhenoFam. 相似文献4.
Arong Luo Huijie Qiao Yanzhou Zhang Weifeng Shi Simon YW Ho Weijun Xu Aibing Zhang Chaodong Zhu 《BMC evolutionary biology》2010,10(1):242
Background
Explicit evolutionary models are required in maximum-likelihood and Bayesian inference, the two methods that are overwhelmingly used in phylogenetic studies of DNA sequence data. Appropriate selection of nucleotide substitution models is important because the use of incorrect models can mislead phylogenetic inference. To better understand the performance of different model-selection criteria, we used 33,600 simulated data sets to analyse the accuracy, precision, dissimilarity, and biases of the hierarchical likelihood-ratio test, Akaike information criterion, Bayesian information criterion, and decision theory. 相似文献5.
Background
Next generation ultra-sequencing technologies are starting to produce extensive quantities of data from entire human genome or exome sequences, and therefore new software is needed to present and analyse this vast amount of information. The 1000 Genomes project has recently released raw data for 629 complete genomes representing several human populations through their Phase I interim analysis and, although there are certain public tools available that allow exploration of these genomes, to date there is no tool that permits comprehensive population analysis of the variation catalogued by such data. 相似文献6.
Irma T. Mercante María D. Bovea Valeria Ibá?ez-Forés Alejandro P. Arena 《The International Journal of Life Cycle Assessment》2012,17(2):232-241
Purpose
The aim of this study is to develop and analyse a life cycle inventory of construction and demolition waste (C&DW) management systems based on primary data collected directly from Spanish enterprises involved in the life cycle of this type of waste material. Special emphasis is placed on assessing the environmental profile of inert waste sorting and treatment (IWST) facilities. 相似文献7.
Johannes Wollbold René Huber Dirk Pohlers Dirk Koczan Reinhard Guthke Raimund W Kinne Ulrike Gausmann 《BMC systems biology》2009,3(1):77-19
Background
Due to the rapid data accumulation on pathogenesis and progression of chronic inflammation, there is an increasing demand for approaches to analyse the underlying regulatory networks. For example, rheumatoid arthritis (RA) is a chronic inflammatory disease, characterised by joint destruction and perpetuated by activated synovial fibroblasts (SFB). These abnormally express and/or secrete pro-inflammatory cytokines, collagens causing joint fibrosis, or tissue-degrading enzymes resulting in destruction of the extra-cellular matrix (ECM). 相似文献8.
Background
High throughput methods of the genome era produce vast amounts of data in the form of gene lists. These lists are large and difficult to interpret without advanced computational or bioinformatic tools. Most existing methods analyse a gene list as a single entity although it is comprised of multiple gene groups associated with separate biological functions. Therefore it is imperative to define and visualize gene groups with unique functionality within gene lists. 相似文献9.
10.
Background
The integration of genomic information with quantitative experimental data is a key component of systems biology. An increasing number of microbial genomes are being sequenced, leading to an increasing amount of data from post-genomics technologies. The genomes of prokaryotes contain many structures of interest, such as operons, pathogenicity islands and prophage sequences, whose behaviour is of interest during infection and disease. There is a need for simple and novel tools to display and analyse data from these integrated datasets, and we have developed ProGenExpress as a tool for visualising arbitrarily complex numerical data in the context of prokaryotic genomes. 相似文献11.
Jesper Kløverpris Henrik Wenzel Per H. Nielsen 《The International Journal of Life Cycle Assessment》2008,13(1):13-21
Background, Aims and Scope
The actual land use consequences of crop consumption are not very well reflected in existing life cycle inventories. The state of the art is that such inventories typically include data from crop production in the country in which the crop is produced, and consequently the inventories do not necessarily consider the land ultimately affected in the systems being studied. The aims of this study are to analyse the mechanisms influencing the long-term land use consequences of changes in crop demand and to propose a methodological framework for identifying these consequences within a global scope. 相似文献12.
13.
Background
A great deal of effort and expense are being expended internationally in attempts to detect genetic polymorphisms contributing to susceptibility to complex human disease. Techniques such as Linkage Disequilibrium mapping are being increasingly used to examine and compare markers across increasingly large datasets. Visualisation techniques are becoming essential to analyse the ever-growing volume of data and results available with any given analysis. 相似文献14.
Stephen F Madden Susan B Carpenter Ian B Jeffery Harry Björkbacka Katherine A Fitzgerald Luke A O'Neill Desmond G Higgins 《BMC bioinformatics》2010,11(1):257
Background
MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression by binding to the messenger RNA (mRNA) of protein coding genes. They control gene expression by either inhibiting translation or inducing mRNA degradation. A number of computational techniques have been developed to identify the targets of miRNAs. In this study we used predicted miRNA-gene interactions to analyse mRNA gene expression microarray data to predict miRNAs associated with particular diseases or conditions. 相似文献15.
Kevin Garwood Christopher Garwood Cornelia Hedeler Tony Griffiths Neil Swainston Stephen G Oliver Norman W Paton 《BMC bioinformatics》2006,7(1):532-14
Background
The proliferation of data repositories in bioinformatics has resulted in the development of numerous interfaces that allow scientists to browse, search and analyse the data that they contain. Interfaces typically support repository access by means of web pages, but other means are also used, such as desktop applications and command line tools. Interfaces often duplicate functionality amongst each other, and this implies that associated development activities are repeated in different laboratories. Interfaces developed by public laboratories are often created with limited developer resources. In such environments, reducing the time spent on creating user interfaces allows for a better deployment of resources for specialised tasks, such as data integration or analysis. Laboratories maintaining data resources are challenged to reconcile requirements for software that is reliable, functional and flexible with limitations on software development resources. 相似文献16.
Genomic taxonomy of vibrios 总被引:1,自引:0,他引:1
Cristiane C Thompson Carolina P Ana Vicente Rangel C Souza Ana Tereza R Vasconcelos Tammi Vesth Nelson Alves Jr David W Ussery Tetsuya Iida Fabiano L Thompson 《BMC evolutionary biology》2009,9(1):258-16
Background
Vibrio taxonomy has been based on a polyphasic approach. In this study, we retrieve useful taxonomic information (i. e. data that can be used to distinguish different taxonomic levels, such as species and genera) from 32 genome sequences of different vibrio species. We use a variety of tools to explore the taxonomic relationship between the sequenced genomes, including Multilocus Sequence Analysis (MLSA), supertrees, Average Amino Acid Identity (AAI), genomic signatures, and Genome BLAST atlases. Our aim is to analyse the usefulness of these tools for species identification in vibrios. 相似文献17.
18.
Objectives
This study aimed to assess relations of self-regulatory skill use with self-efficacy for exercise and appropriate eating, and the resulting change in weight associated with participation in a nutrition and exercise treatment supported by cognitive-behavioral methods. 相似文献19.
Background
Hepatotoxicity is one of the most serious complications of highly active antiretroviral therapy (HAART). The aim of this report is to analyse an HIV infected patient on HAART including nevirapine and taking antidepressive agents, with acute toxic hepatitis. 相似文献20.
Teresa Olczak Halina Wójtowicz Justyna Ciuraszkiewicz Mariusz Olczak 《BMC microbiology》2010,10(1):134